| Role of protein kinase D1 in vasoconstriction and haemodynamics in rats. | Role of protein kinase D1 in vasoconstriction and haemodynamics in rats.
Sugawara Y, Mizuno Y, Oku S, Sawada Y, Goto T. | 02/9/2024 |
| Protein kinase D1 promotes the survival of random-pattern skin flaps in rats. | Protein kinase D1 promotes the survival of random-pattern skin flaps in rats.
Chen J, Chen H, Muhammad I, Han T, Zhang D, Li B, Zhou X, Zhou F. | 01/21/2023 |
| The results suggest that PKD participates in the development of cardiac hypertrophy by regulating autophagy via AKT/mTOR/S6K pathway. | PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte.
Zhao D, Gao Y, Wang W, Pei H, Xu C, Zhao Z. | 07/18/2020 |
| siRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation. | Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E., Free PMC Article | 05/13/2017 |
| Study delineates the protein kinase D1 binding sites on HSP20 and shows that HSP20 is a substrate for protein kinase D1. | Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).
Sin YY, Baillie GS., Free PMC Article | 08/27/2016 |
| PKD1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells. | Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.
Sinnett-Smith J, Ni Y, Wang J, Ming M, Young SH, Rozengurt E., Free PMC Article | 06/28/2014 |
| Data suggest Fhl1 (four-and-a-half LIM domains protein 1) and FHL2 (four-and-a-half LIM domains protein 2) bind to/regulate activity of Prkd1 (protein kinase D 1) in cardiac/ventricular myocytes; knockdown of Fhl1/FHL2 downregulates Prkd1 activation. | Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.
Stathopoulou K, Cuello F, Candasamy AJ, Kemp EM, Ehler E, Haworth RS, Avkiran M., Free PMC Article | 03/22/2014 |
| Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes. | Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Steinbusch LK, Dirkx E, Hoebers NT, Roelants V, Foretz M, Viollet B, Diamant M, van Eys G, Ouwens DM, Bertrand L, Glatz JF, Luiken JJ. | 07/6/2013 |
| PKD facilitates contraction of cardiomyocytes by increasing Ca(2+) sensitivity and by an increased calcium-activated tension of contraction through phosphorylation of cMyBP-C. | Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.
Dirkx E, Cazorla O, Schwenk RW, Lorenzen-Schmidt I, Sadayappan S, Van Lint J, Carrier L, van Eys GJ, Glatz JF, Luiken JJ., Free PMC Article | 10/13/2012 |
| a novel contraction-induced ROS-DAPK-PKD1 pathway in cardiomyocytes | Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes.
Dirkx E, Schwenk RW, Coumans WA, Hoebers N, Angin Y, Viollet B, Bonen A, van Eys GJ, Glatz JF, Luiken JJ., Free PMC Article | 04/14/2012 |
| The alpha(1)-adrenergic stimulation releases Rem1 inhibition of voltage-gated L-type calcium channels through direct phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in an increase of the channel activity and transverse-tubule expression. | Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.
Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CMB, Jin ZG., Free PMC Article | 03/31/2012 |
| These results demonstrate that CCK(A) receptor activation leads to PKD activation by signaling through PKC-dependent and PKC-independent pathways. | CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways.
Berna MJ, Hoffmann KM, Tapia JA, Thill M, Pace A, Mantey SA, Jensen RT., Free PMC Article | 10/7/2011 |
| cAMP pools controlled by PDE3 and PDE4, but not PDE2, regulate the PKA activity that inhibits ET1-induced PKD activation. | Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation.
Haworth RS, Cuello F, Avkiran M., Free PMC Article | 04/23/2011 |
| localized PKD may play a role as a dynamic regulator of Ca(2+) sensitivity of contraction in cardiac myocytes | Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction.
Goodall MH, Wardlow RD 2nd, Goldblum RR, Ziman A, Lederer WJ, Randall W, Rogers TB., Free PMC Article | 02/26/2011 |
| Data suggest that activation of protein kinase D may represent a novel signaling pathway linking mGluR5 to its downstream targets. | Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons.
Krueger DD, Osterweil EK, Bear MF., Free PMC Article | 01/1/2011 |
| A(2)AR-PKCmu-MEK signaling mediates Ado-stimulated adrenal steroidogenesis | Protein kinase Cμ mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells.
Chen YC, Chen Y, Huang SH, Wang SM. | 11/27/2010 |
| Studies define PKD as a principal cardiac class Class IIa histone deacetylases. | A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase.
Monovich L, Vega RB, Meredith E, Miranda K, Rao C, Capparelli M, Lemon DD, Phan D, Koch KA, Chapo JA, Hood DB, McKinsey TA. | 02/22/2010 |
| In rats, streptozotocin treated cardiomyoctes show an increas in proteolysis of protein kinase D. | Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation.
Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B., Free PMC Article | 01/21/2010 |
| Our results identify PKD1 as a novel early convergent point for PKCdelta and epsilon in the signaling pathways mediating NF-kappaB activation in pancreatitis. | Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells.
Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Rozengurt E, Pandol SJ., Free PMC Article | 01/21/2010 |
| These findings suggest that PKD protects intestinal cells through up-regulation of NF-kappaB and down-regulation of p38 MAPK. | PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells.
Song J, Li J, Qiao J, Jain S, Mark Evers B, Chung DH., Free PMC Article | 01/21/2010 |
| These results suggest that in neurons PKD1 regulates TGN-derived sorting of dendritic proteins and hence has a role in neuronal polarity. | Protein kinase d regulates trafficking of dendritic membrane proteins in developing neurons.
Bisbal M, Conde C, Donoso M, Bollati F, Sesma J, Quiroga S, Díaz Añel A, Malhotra V, Marzolo MP, Cáceres A., Free PMC Article | 01/21/2010 |
| Propose a model where ENH1 scaffolds PKD1 to Cacna1c in order to form a signalling complex that regulates the activity of cardiac L-type voltage-gated Ca(2+) channels. | Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel.
Maturana AD, Wälchli S, Iwata M, Ryser S, Van Lint J, Hoshijima M, Schlegel W, Ikeda Y, Tanizawa K, Kuroda S., Free PMC Article | 01/21/2010 |
| Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart | Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart.
Ozgen N, Obreztchikova M, Guo J, Elouardighi H, Dorn GW 2nd, Wilson BA, Steinberg SF., Free PMC Article | 01/21/2010 |
| Elude to a role of PKD in contraction-induced GLUT4 translocation which does not involve AMPK-alpha2. | Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF. | 01/21/2010 |
| findings demonstrate that thrombin induces activation of PKD and reveal a novel role of PKC delta in mediating thrombin-induced PKD activation in vascular smooth muscle cells | Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation.
Tan M, Xu X, Ohba M, Ogawa W, Cui MZ. | 01/21/2010 |