| The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD[+] Metabolism with Phosphate Sensing in Saccharomyces cerevisiae. | The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD(+) Metabolism with Phosphate Sensing in Saccharomyces cerevisiae.
Groth B, Lee YC, Huang CC, McDaniel M, Huang K, Lee LH, Lin SJ., Free PMC Article | 06/7/2023 |
| The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD(+) metabolism in the budding yeast Saccharomyces cerevisiae. | The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD(+) metabolism in the budding yeast Saccharomyces cerevisiae.
Groth B, Huang CC, Lin SJ., Free PMC Article | 11/12/2022 |
| RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in rho(0) cells of Saccharomyces cerevisiae. | RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in ρ(0) cells of Saccharomyces cerevisiae.
Yamada Y., Free PMC Article | 01/22/2022 |
| Genetic screen for suppressors of increased silencing in rpd3 mutants in Saccharomyces cerevisiae identifies a potential role for H3K4 methylation. | Genetic screen for suppressors of increased silencing in rpd3 mutants in Saccharomyces cerevisiae identifies a potential role for H3K4 methylation.
Kleinschmidt RA, Lyon LM, Smith SL, Rittenberry J, Lawless KM, Acosta AA, Donze D., Free PMC Article | 01/15/2022 |
| The Rpd3-Complex Regulates Expression of Multiple Cell Surface Recycling Factors in Yeast. | The Rpd3-Complex Regulates Expression of Multiple Cell Surface Recycling Factors in Yeast.
Amoiradaki K, Bunting KR, Paine KM, Ayre JE, Hogg K, Laidlaw KME, MacDonald C., Free PMC Article | 12/25/2021 |
| NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics. | NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics.
Kim JH, Yoon CY, Jun Y, Lee BB, Lee JE, Ha SD, Woo H, Choi A, Lee S, Jeong W, Kim JH, Kim T., Free PMC Article | 11/21/2020 |
| Gcn5 and Rpd3 have a limited role in the regulation of cell cycle transcripts during the G1 and S phases in Saccharomyces cerevisiae. | Gcn5 and Rpd3 have a limited role in the regulation of cell cycle transcripts during the G1 and S phases in Saccharomyces cerevisiae.
Kishkevich A, Cooke SL, Harris MRA, de Bruin RAM., Free PMC Article | 10/24/2020 |
| Rpd3L and Hda1 histone deacetylase complexes contribute to the repair of replication-born double strand breaks by facilitating cohesin loading. | Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion.
Ortega P, Gómez-González B, Aguilera A., Free PMC Article | 03/14/2020 |
| Data sugget that an active mark, H3K4me3 enriched at active promoters, instructs histone deacetylase RPD3 (Rpd3L HDAC) to induce histone deacetylation and termed transcriptional repression memory (TREM). | Rpd3L HDAC links H3K4me3 to transcriptional repression memory.
Lee BB, Choi A, Kim JH, Jun Y, Woo H, Ha SD, Yoon CY, Hwang JT, Steinmetz L, Buratowski S, Lee S, Kim HY, Kim T., Free PMC Article | 08/17/2019 |
| Our findings present the first evidence that H3K4me and H3K36me act combinatorially to control Rpd3S. | Combinatorial Genetic Control of Rpd3S Through Histone H3K4 and H3K36 Methylation in Budding Yeast.
Lee KY, Ranger M, Meneghini MD., Free PMC Article | 03/23/2019 |
| evidence that the Rpd3/Sin3/Ume6 histone deacetylase complex, which represses meiotic genes during mitosis, also prevents the induction of BOI1's 5'-extended isoform in mitosis by direct binding of Ume6 to its URS1 target | The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae.
Liu Y, Stuparevic I, Xie B, Becker E, Law MJ, Primig M. | 02/6/2016 |
| Deletion of RPD3 prevents cells from establishing transcriptional quiescence, leading to defects in quiescence entry and shortening of chronological lifespan. | Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry.
McKnight JN, Boerma JW, Breeden LL, Tsukiyama T., Free PMC Article | 11/28/2015 |
| Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation. | Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.
Aihara M, Jin X, Kurihara Y, Yoshida Y, Matsushima Y, Oku M, Hirota Y, Saigusa T, Aoki Y, Uchiumi T, Yamamoto T, Sakai Y, Kang D, Kanki T. | 04/25/2015 |
| These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II. | Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.
Burugula BB, Jeronimo C, Pathak R, Jones JW, Robert F, Govind CK., Free PMC Article | 02/14/2015 |
| Results show that Rpd3 and Sir2 control replication timing in an opposite manner. Whereas Rpd3 delays initiation at late origins, Sir2 is required for the timely activation of early origins | The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast.
Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, Ginalski K, Lengronne A, Pasero P. | 07/12/2014 |
| Data indicate that chromatin remodelers enhance Rpd3S activity by altering nucleosomal spacing. | Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S.
Lee CH, Wu J, Li B., Free PMC Article | 01/18/2014 |
| An important role for Rpd3 in promoting checkpoint adaptation via deacetylation and inhibition of Rad53. | Deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 overactivation.
Tao R, Xue H, Zhang J, Liu J, Deng H, Chen YG., Free PMC Article | 12/14/2013 |
| Data indicate that Snt2, Ecm5, and Rpd3 physically associate. | The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress.
Baker LA, Ueberheide BM, Dewell S, Chait BT, Zheng D, Allis CD., Free PMC Article | 11/30/2013 |
| The Rpd3L histone deacetylase complex was required for diauxic shift-induced histone H4 and H2B deposition onto rDNA genes. | Rpd3- and spt16-mediated nucleosome assembly and transcriptional regulation on yeast ribosomal DNA genes.
Johnson JM, French SL, Osheim YN, Li M, Hall L, Beyer AL, Smith JS., Free PMC Article | 08/31/2013 |
| Interactions between HMT1 and genes encoding components of the histone deacetylase complex Rpd3L, are reported. | Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1.
Milliman EJ, Yadav N, Chen YC, Muddukrishna B, Karunanithi S, Yu MC., Free PMC Article | 02/9/2013 |
| The telomeric-bound protein, Rif2, was also found to promote a telomere fold-back through the recruitment of Rpd3L to telomeres | Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.
Poschke H, Dees M, Chang M, Amberkar S, Kaderali L, Rothstein R, Luke B., Free PMC Article | 01/5/2013 |
| analysis of distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes | Expression noise and acetylation profiles distinguish HDAC functions.
Weinberger L, Voichek Y, Tirosh I, Hornung G, Amit I, Barkai N., Free PMC Article | 10/13/2012 |
| Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels | Ume6 transcription factor is part of a signaling cascade that regulates autophagy.
Bartholomew CR, Suzuki T, Du Z, Backues SK, Jin M, Lynch-Day MA, Umekawa M, Kamath A, Zhao M, Xie Z, Inoki K, Klionsky DJ., Free PMC Article | 10/6/2012 |
| Rpd3 core complex could contribute to repression via a novel nucleosome stabilization function. | The Rpd3 core complex is a chromatin stabilization module.
Chen XF, Kuryan B, Kitada T, Tran N, Li JY, Kurdistani S, Grunstein M, Li B, Carey M., Free PMC Article | 08/11/2012 |
| Mutation or inhibition of yeast Rpd3L or Hda1 suppressed up to 90% of CTG*CAG repeat expansions. | Histone deacetylase complexes promote trinucleotide repeat expansions.
Debacker K, Frizzell A, Gleeson O, Kirkham-McCarthy L, Mertz T, Lahue RS., Free PMC Article | 06/30/2012 |