| The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications. | The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.
Deng B, Kong W, Shen X, Han C, Zhao Z, Chen S, Zhou C, Bae-Jump V., Free PMC Article | 03/20/2024 |
| Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress. | Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress.
Cui H, Wang Y, Zhou T, Qu L, Zhang X, Wang Y, Han M, Yang S, Ren X, Wang G, Gang X. | 01/15/2024 |
| The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. | The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background.
Irshad Z, Lund J, Sillars A, Løvsletten NG, Gharanei S, Salt IP, Freeman DJ, Gill JMR, Thoresen GH, Rustan AC, Zammit VA., Free PMC Article | 10/24/2023 |
| Lipid droplets in Zika neuroinfection: Potential targets for intervention? | Lipid droplets in Zika neuroinfection: Potential targets for intervention?
Dias SSG, Cunha-Fernandes T, Soares VC, de Almeida CJ, Bozza PT., Free PMC Article | 10/15/2023 |
| Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes. | Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.
Selvaraj R, Zehnder SV, Watts R, Lian J, Das C, Nelson R, Lehner R. | 09/12/2023 |
| DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma. | DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.
Kang H, Lee H, Kim K, Shin E, Kim B, Kang J, Kim B, Lee JS, Lee JM, Youn H, Youn B., Free PMC Article | 03/1/2023 |
| An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. | An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.
Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q., Free PMC Article | 08/27/2022 |
| DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis. | DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis.
Xia L, Wang Y, Cai S, Xu M., Free PMC Article | 12/11/2021 |
| Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress. | Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress.
Cheng X, Geng F, Pan M, Wu X, Zhong Y, Wang C, Tian Z, Cheng C, Zhang R, Puduvalli V, Horbinski C, Mo X, Han X, Chakravarti A, Guo D., Free PMC Article | 11/13/2021 |
| Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells. | Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells.
Morales A, Greenberg M, Nardi F, Gil V, Hayward SW, Crawford SE, Franco OE., Free PMC Article | 09/11/2021 |
| Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer. | Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer.
He P, Cheng S, Hu F, Ma Z, Xia Y., Free PMC Article | 05/15/2021 |
| Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism. | Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism.
Gupta A, Dsouza NR, Zarate YA, Lombardo R, Hopkin R, Linehan AR, Simpson J, McCarrier J, Agre KE, Gavrilova RH, Stephens MC, Grothe RM, Monaghan KG, Xie Y, Basel D, Urrutia RA, Cole CR, Klee EW, Zimmermann MT. | 03/27/2021 |
| DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130. | DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.
Nardi F, Franco OE, Fitchev P, Morales A, Vickman RE, Hayward SW, Crawford SE., Free PMC Article | 09/19/2020 |
| cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate | Structure and mechanism of human diacylglycerol O-acyltransferase 1.
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M., Free PMC Article | 07/18/2020 |
| structure of dimeric human DGAT1, a member of the membrane-bound O-acyltransferase (MBOAT) family, by cryo-electron microscopy at approximately 3.0 A resolution | Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr., Free PMC Article | 07/4/2020 |
| Decreased DGAT1 activity can reduce circulating TG and liver TG. | A population analysis of the DGAT1 inhibitor GSK3008356 and its effect on endogenous and meal-induced triglyceride turnover in healthy subjects.
Okour M, Brigandi RA, Tenero D. | 04/11/2020 |
| Identified 1 patient with compound heterozygous CCBE1 and 2 with novel DGAT1 mutations in cohort of 9 Chinese children. Two of the 3 patients with DGAT1 mutations died, suggesting that this genotype is associated with an especially severe phenotype. | Phenotype and Genotype of a Cohort of Chinese Children with Early-Onset Protein-Losing Enteropathy.
Ye Z, Huang Y, Wang Y, Lu J, Wu J, Yu Z. | 04/11/2020 |
| DGAT1 loss causes global changes in enterocyte polarized trafficking that could account for deficits in absorption seen in the patient with neonatal diarrhea. | Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase.
Schlegel C, Lapierre LA, Weis VG, Williams JA, Kaji I, Pinzon-Guzman C, Prasad N, Boone B, Jones A, Correa H, Levy SE, Han X, Wang M, Thomsen K, Acra S, Goldenring JR., Free PMC Article | 07/27/2019 |
| Study identified a large cohort of patients with congenital diarrheal disorders with mutations in DGAT1 that reduced expression of its product; dermal fibroblasts and intestinal organoids derived from these patients had altered lipid metabolism and were susceptible to lipid-induced cell death. Expression of full-length wildtype DGAT1 or DGAT2 restored normal lipid metabolism in these cells. | Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency.
van Rijn JM, Ardy RC, Kuloğlu Z, Härter B, van Haaften-Visser DY, van der Doef HPJ, van Hoesel M, Kansu A, van Vugt AHM, Thian M, Kokke FTM, Krolo A, Başaran MK, Kaya NG, Aksu AÜ, Dalgıç B, Ozcay F, Baris Z, Kain R, Stigter ECA, Lichtenbelt KD, Massink MPG, Duran KJ, Verheij JBGM, Lugtenberg D, Nikkels PGJ, Brouwer HGF, Verkade HJ, Scheenstra R, Spee B, Nieuwenhuis EES, Coffer PJ, Janecke AR, van Haaften G, Houwen RHJ, Müller T, Middendorp S, Boztug K., Free PMC Article | 08/25/2018 |
| our findings indicate that inhibition of both DGAT1 and ABHD5 using siRNA leads to reduction in prostate cancer cell growth. | Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5.
Mitra R, Le TT, Gorjala P, Goodman OB Jr., Free PMC Article | 05/12/2018 |
| data reveal an important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes. | Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV Jr., Free PMC Article | 04/21/2018 |
| DGAT1 mutations result in a spectrum of diseases | Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV Jr., Free PMC Article | 01/20/2018 |
| A novel homozygous missense variant was identified in a family with protein losing enteropathy. A splice site mutation in intron 8 was identified in a second family with PLE. These cases of DGAT1 deficiency extend the molecular and phenotypic spectrum of PLE. | Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations.
Stephen J, Vilboux T, Haberman Y, Pri-Chen H, Pode-Shakked B, Mazaheri S, Marek-Yagel D, Barel O, Di Segni A, Eyal E, Hout-Siloni G, Lahad A, Shalem T, Rechavi G, Malicdan MC, Weiss B, Gahl WA, Anikster Y., Free PMC Article | 07/29/2017 |
| DGAT1 expression is down-regulated in viral hepatitis-related cirrhosis. | Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells.
Chang S, Sung PS, Lee J, Park J, Shin EC, Choi C., Free PMC Article | 01/14/2017 |
| Data indicate no clinically relevant pharmacokinetic interaction between DGAT-1 inhibitor pradigastat and rosuvastatin. | Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.
Kulmatycki K, Hanna I, Meyers D, Salunke A, Movva A, Majumdar T, Natrillo A, Vapurcuyan A, Rebello S, Sunkara G, Chen J. | 08/29/2015 |