| Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma. | Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma.
Al-Lamki RS, Wang J, Pober JS, Bradley JR. | 05/14/2022 |
| Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia. | Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia.
Charkiewicz K, Goscik J, Raba G, Laudanski P. | 07/24/2021 |
| TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses. | TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses.
Oriol-Tordera B, Olvera A, Duran-Castells C, Llano A, Mothe B, Massanella M, Dalmau J, Ganoza C, Sanchez J, Calle ML, Clotet B, Martinez-Picado J, Negredo E, Blanco J, Hartigan-O'Connor D, Brander C, Ruiz-Riol M., Free PMC Article | 04/17/2021 |
| The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. | The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
Rodriguez-Barbosa JI, Schneider P, Graca L, Bühler L, Perez-Simon JA, Del Rio ML., Free PMC Article | 02/20/2021 |
| Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism. | Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism.
Della Bella S, Calcaterra F, Bacci M, Carenza C, Pandolfo C, Ferrazzi P, Uva P, Pagani M, Lodigiani C, Mavilio D. | 10/24/2020 |
| The identifies a new inflammatory mechanism in Mucosal-associated invariant T cells linking the DR3/TL1A axis with amplification of TCR-dependent and -independent effector functions, particularly inducing excessive innate TNF-alpha production. | The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells.
Sattler A, Thiel LG, Ruhm AH, Souidi N, Seifert M, Herberth G, Kotsch K. | 05/30/2020 |
| In contrast to pre-menopausal females, post-menopausal serum levels of TL1A are not significantly elevated and that DR3 expression is not induced on CD14+ monocytes. Murine ovariectomy (OVX) model of estrogen-deficiency revealed that early post-OVX expression of DR3 on CD4+ T cells is significantly elevated suggesting that DR3 and TL1A could play a potentially indirect role in early post-menopausal bone loss. | Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.
Collins FL, Stone MD, Turton J, McCabe LR, Wang ECY, Williams AS., Free PMC Article | 01/4/2020 |
| Findings clarify the process and consequences of death receptor 3 (DR3) signaling-induced intestinal inflammation through regulation of group 3 innate lymphoid cells (ILC3s). | Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation.
Li J, Shi W, Sun H, Ji Y, Chen Y, Guo X, Sheng H, Shu J, Zhou L, Cai T, Qiu J., Free PMC Article | 01/4/2020 |
| Hypermethylation of the proapoptotic genes BCL2 L11 and TNFRSF25 is observed in pleomorphic adenoma of the salivary glands. However, this phenomenon did not impact mRNA transcription. | DNA methylation polymerase chain reaction (PCR) array of apoptosis-related genes in pleomorphic adenomas of the salivary glands.
Pereira NB, do Carmo ACM, Campos K, Costa SFDS, Diniz MG, Gomez RS, Gomes CC. | 06/2/2018 |
| the DR3/TL1A pathway directly enhances human OC formation and resorptive activity, controlling expression and activation of CCL3 and MMP-9. | CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss.
Collins FL, Williams JO, Bloom AC, Singh RK, Jordan L, Stone MD, McCabe LR, Wang ECY, Williams AS., Free PMC Article | 12/23/2017 |
| Untreated children with IBD have higher percentage of DR3(+) PBMCs. | Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD.
Slebioda TJ, Bojarska-Junak A, Cyman M, Landowski P, Kaminska B, Celinski K, Kmiec Z. | 10/21/2017 |
| In addition to apoptosis, DR3 can robustly trigger necroptotic cell death and provide evidence for TL1A-induced, DR3-mediated necrosome assembly. DR3-mediated necroptosis critically depends on receptor-interacting protein 1 (RIP1) and RIP3, the core components of the necroptotic machinery, which activate the pseudo-kinase mixed lineage kinase domain-like, the prototypic downstream effector molecule of necroptosis. | Death receptor 3 mediates necroptotic cell death.
Bittner S, Knoll G, Ehrenschwender M. | 08/26/2017 |
| Data suggest that human regulatory T-lymphocytes express DR3 and demonstrate DR3/TL1A-mediated activation of signaling via MAP kinases and NFkappaB. (DR3 = death receptor 3; TL1A/TNFSF15 = tumor necrosis factor [ligand] superfamily, member 15) | Death receptor 3 signaling enhances proliferation of human regulatory T cells.
Bittner S, Knoll G, Ehrenschwender M. | 08/12/2017 |
| These results raise the possibility for involvement of TL1A/DR3/DR3-mediated mechanisms in epithelial-mesenchymal interactions and the development of inflammation-induced intestinal fibrosis in Crohn's disease. | Crohn's disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells.
Bamias G, Filidou E, Goukos D, Valatas V, Arvanitidis K, Panagopoulou M, Kouklakis G, Daikos GL, Ladas SD, Kolios G. | 07/1/2017 |
| Activation of DR3 is accompanied by inhibition of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis. | DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis.
Filatova EN, Anisenkova EV, Presnyakova NB, Utkin OV. | 03/4/2017 |
| Biologics beyond TNF-alpha inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders. | Biologics beyond TNF-α inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders.
Tougaard P, Zervides KA, Skov S, Hansen AK, Pedersen AE. | 11/5/2016 |
| Higher DR3 levels were associated with early stage chronic lymphocytic leukemia. | Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia.
Cavallini C, Lovato O, Bertolaso A, Zoratti E, Malpeli G, Mimiola E, Tinelli M, Aprili F, Tecchio C, Perbellini O, Scarpa A, Zamò A, Cassatella MA, Pizzolo G, Scupoli MT., Free PMC Article | 08/20/2016 |
| DR3 is efficiently activated by soluble TL1A trimers. | Soluble TL1A is sufficient for activation of death receptor 3.
Bittner S, Knoll G, Füllsack S, Kurz M, Wajant H, Ehrenschwender M. | 07/30/2016 |
| These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition. | Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice.
Collins FL, Williams JO, Bloom AC, Stone MD, Choy E, Wang EC, Williams AS., Free PMC Article | 03/26/2016 |
| Human memory IL-18Ralpha and DR3 CD4+ T cells may contribute to antigen-independent innate responses at barrier surfaces. | A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.
Holmkvist P, Roepstorff K, Uronen-Hansson H, Sandén C, Gudjonsson S, Patschan O, Grip O, Marsal J, Schmidtchen A, Hornum L, Erjefält JS, Håkansson K, Agace WW., Free PMC Article | 03/12/2016 |
| DR3 is expressed by IL-22-producing human group 3 innate lymphoid cells (ILC3s). | Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
Ahn YO, Weeres MA, Neulen ML, Choi J, Kang SH, Heo DS, Bergerson R, Blazar BR, Miller JS, Verneris MR., Free PMC Article | 10/31/2015 |
| These results suggested that TL1A could promote Th17 differentiation in rheumatoid arthritis via the activation of RORc, and this effect may be mediated by the binding of TL1A with DR3. | TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis.
Zhou M, Liu R, Su D, Feng X, Li X. | 09/12/2015 |
| Silencing of the DR3 gene affect levels of apoptosis antigen3 ligand in cells. | The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells.
Zhang YC, Guo LQ, Chen X, Wang GN, Ni R, Wang MC, Wei FX., Free PMC Article | 08/1/2015 |
| DR3 is expressed in some interstitial vascular endothelial cells in human kidney in situ. These EC also respond to TL1A by activating NF-kappaB. Very low levels of DR3 are seen on the cell surface of HUVEC, which do not respond to TL1A. | TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells.
Wang J, Al-Lamki RS, Zhu X, Liu H, Pober JS, Bradley JR., Free PMC Article | 06/6/2015 |
| The changes in frequency of occurrence of spliced variants of DR3/LARD mRNA were directed towards modulation of apoptosis and restraint of antiviral immune response. | [Frequency of the occurrence of spliced variants of the messenger RNA DR3/LARD in herpesviral infection].
Utkin OV, Starikova VD, Novikov VV. | 05/23/2015 |