| Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors. | Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors.
Puig-Blasco L, Piotrowski KB, Michaelsen SR, Bager NS, Areškevičiūtiė A, Thorseth ML, Sun XF, Keller UAD, Kristensen BW, Madsen DH, Gnosa SP, Kveiborg M. | 10/30/2023 |
| Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway. | Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway.
Aujla PK, Hu M, Hartley B, Kranrod JW, Viveiros A, Kilic T, Owen CA, Oudit GY, Seubert JM, Julien O, Kassiri Z. | 12/17/2022 |
| ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma. | ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma.
Xu JH, Guan YJ, Zhang YC, Qiu ZD, Zhou Y, Chen C, Yu J, Wang WX., Free PMC Article | 02/5/2022 |
| A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts. | A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts.
Janczi T, Meier F, Fehrl Y, Kinne RW, Böhm B, Burkhardt H., Free PMC Article | 12/4/2021 |
| ADAM15 expression is increased in lung CD8(+) T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction. | ADAM15 expression is increased in lung CD8(+) T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.
Wang X, Zhang D, Higham A, Wolosianka S, Gai X, Zhou L, Petersen H, Pinto-Plata V, Divo M, Silverman EK, Celli B, Singh D, Sun Y, Owen CA., Free PMC Article | 06/12/2021 |
| ADAM15 Participates in Tick-Borne Encephalitis Virus Replication. | ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.
Yang Q, Pei R, Wang Y, Zhou Y, Yang M, Chen X, Chen J., Free PMC Article | 05/15/2021 |
| ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells. | ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells.
Mattern J, Roghi CS, Hurtz M, Knäuper V, Edwards DR, Poghosyan Z., Free PMC Article | 11/21/2020 |
| ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm. | ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
Jana S, Chute M, Hu M, Winkelaar G, Owen CA, Oudit GY, Kassiri Z., Free PMC Article | 10/10/2020 |
| The absence of ADAM15 at low shear stress or static conditions may therefore lead to increased endothelial damage. | The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells.
Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. | 06/27/2020 |
| The data show that ADAM15 plays a role in rheumatoid arthritis angiogenesis, suggesting that ADAM15 might be a potential target in inflammatory diseases such as rheumatoid arthritis. | A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis.
Nishimi S, Isozaki T, Wakabayashi K, Takeuchi H, Kasama T., Free PMC Article | 12/14/2019 |
| The antiapoptotic effect of ADAM15 in FasL-stimulated cells was demonstrated either by increased apoptosis of cells transfected with an ADAM15 construct lacking the cytoplasmic domain compared to cells transfected with full-length ADAM15 or by reduced apoptosis resistance of rheumatoid arthritis synovial fibroblasts upon RNA interference silencing of ADAM15. | ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment.
Janczi T, Böhm BB, Fehrl Y, DeGiacomo P, Kinne RW, Burkhardt H. | 11/2/2019 |
| ET-1 expression in the endothelial cells of diabetic foot ulcers is an important determinant of insulin resistance at the onset of disease and induces macrophages to produce NF-kappaB, which regulates inflammation. It is thought that ADAM 15 contributes to angiogenic effects as a means of stimulating endothelial cells | Endothelin 1, NF-κB, and ADAM-15 expression in diabetic foot wounds.
Atic R, Deveci E. | 07/13/2019 |
| The results of our study demonstrate that ADAM15 is strongly up regulated in a small but highly aggressive fraction of prostate cancers. | Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.
Burdelski C, Fitzner M, Hube-Magg C, Kluth M, Heumann A, Simon R, Krech T, Clauditz T, Büscheck F, Steurer S, Wittmer C, Hinsch A, Luebke AM, Jacobsen F, Minner S, Tsourlakis MC, Beyer B, Steuber T, Thederan I, Sauter G, Izbicki J, Schlomm T, Wilczak W., Free PMC Article | 08/12/2017 |
| Data show that ADAM9 silencing affected MMP2 and ADAM15 expression. | ADAM9 silencing inhibits breast tumor cells transmigration through blood and lymphatic endothelial cells.
Micocci KC, Moritz MN, Lino RL, Fernandes LR, Lima AG, Figueiredo CC, Morandi V, Selistre-de-Araujo HS. | 02/4/2017 |
| ADAM15 promotes lung cancer cell invasion through directly targeting MMP9 activation. | ADAM15 targets MMP9 activity to promote lung cancer cell invasion.
Dong DD, Zhou H, Li G. | 07/30/2016 |
| the results revealed an undescribed role of ADAM15 in the invasion of human bladder cancer and suggested that the ADAM15 catalytic domain may represent a viable therapeutic target in patients with advanced disease. | ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer.
Lorenzatti Hiles G, Bucheit A, Rubin JR, Hayward A, Cates AL, Day KC, El-Sawy L, Kunju LP, Daignault S, Lee CT, Liebert M, Hussain M, Day ML., Free PMC Article | 07/30/2016 |
| present a tumor suppressive mechanism for ADAM15 exosomes and provide insight into the functional significance of exosomes that generate tumor-inhibitory factors | The ADAM15 ectodomain is shed from secretory exosomes.
Lee HD, Kim YH, Koo BH, Kim DS., Free PMC Article | 02/27/2016 |
| these data suggest the potential role of miR147b in regulating endothelial barrier function by targeting ADAM15 expression. | MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression.
Chatterjee V, Beard RS Jr, Reynolds JJ, Haines R, Guo M, Rubin M, Guido J, Wu MH, Yuan SY., Free PMC Article | 12/19/2015 |
| The severity of intrauterine adhesions positively correlates to the protein and transcript expression levels of ADAM-15 and ADAM-17 in uterine tissue. | Molecular implication of ADAM-15 and -17 in intrauterine adhesions.
Liu D, Ha C, Zhang X, Zhang Z, Liu P. | 06/7/2014 |
| ADAM15 contributes to apoptosis resistance in rheumatoid arthritis synovial fibroblasts by activating the Src/FAK pathway upon FasL exposure. | ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling.
Böhm BB, Freund I, Krause K, Kinne RW, Burkhardt H. | 01/4/2014 |
| In conclusion, our data identified rhddADAM15 as a potent inhibitor of tumor growth and metastasis, making it a promising tool for use in anticancer treatment. | Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells.
Hou Y, Chu M, Du FF, Lei JY, Chen Y, Zhu RY, Gong XH, Ma X, Jin J. | 08/31/2013 |
| ADAM15 acts as a negative regulator of TRIF-mediated NF-kappaB and IFN-beta reporter gene activity via TLR3 and TLR4 signaling. | TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15.
Ahmed S, Maratha A, Butt AQ, Shevlin E, Miggin SM. | 04/6/2013 |
| dispensable for cutaneous wound healing and B16F1 melanoma growth, but significantly contributes to metastasis formation | Role of ADAM-15 in wound healing and melanoma development.
Schönefuß A, Abety AN, Zamek J, Mauch C, Zigrino P. | 09/29/2012 |
| Exosomes rich in ADAM15 display enhanced binding affinity for integrin alphavbeta3 in an RGD-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. | Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.
Lee HD, Koo BH, Kim YH, Jeon OH, Kim DS. | 09/22/2012 |
| ADAM15 tail can transduce a percepted extracellular signal to enhance FAK and Src phosphorylation. | ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.
Fried D, Böhm BB, Krause K, Burkhardt H., Free PMC Article | 08/25/2012 |