| The prognostic impact of SIGLEC5-induced impairment of CD8[+] T cell activation in sepsis. | The prognostic impact of SIGLEC5-induced impairment of CD8(+) T cell activation in sepsis.
Lozano-Rodríguez R, Avendaño-Ortíz J, Montalbán-Hernández K, Ruiz-Rodríguez JC, Ferrer R, Martín-Quirós A, Maroun-Eid C, González-López JJ, Fàbrega A, Terrón-Arcos V, Gutiérrez-Fernández M, Alonso-López E, Cubillos-Zapata C, Fernández-Velasco M, Pérez de Diego R, Pelegrin P, García-Palenciano C, Cueto FJ, Del Fresno C, López-Collazo E., Free PMC Article | 11/15/2023 |
| PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea. | PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.
Díaz-García E, García-Sánchez A, Alfaro E, López-Fernández C, Mañas E, Cano-Pumarega I, López-Collazo E, García-Río F, Cubillos-Zapata C., Free PMC Article | 11/1/2023 |
| Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology. | Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.
Müller R, Freitag-Wolf S, Weiner J 3rd, Chopra A, Top T, Dommisch H, Schaefer AS. | 12/24/2022 |
| Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13. | Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13.
Akiyama M, Eura Y, Kokame K. | 10/22/2022 |
| Siglec-5 is an inhibitory immune checkpoint molecule for human T cells. | Siglec-5 is an inhibitory immune checkpoint molecule for human T cells.
Vuchkovska A, Glanville DG, Scurti GM, Nishimura MI, White P, Ulijasz AT, Iwashima M. | 05/28/2022 |
| Periodontitis Risk Variants at SIGLEC5 Impair ERG and MAFB Binding. | Periodontitis Risk Variants at SIGLEC5 Impair ERG and MAFB Binding.
Mueller R, Chopra A, Dommisch H, Schaefer AS., Free PMC Article | 04/30/2022 |
| Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis. | Genetic susceptibility of common polymorphisms in NIN and SIGLEC5 to chronic periodontitis.
Tong H, Wei Z, Yin J, Zhang B, Zhang T, Deng C, Huang Y, Zhang N., Free PMC Article | 09/12/2020 |
| Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. | Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome.
Lee J, Lee J, Baek S, Koh JH, Kim JW, Kim SY, Chung SH, Choi SS, Cho ML, Kwok SK, Ju JH, Park SH. | 07/18/2020 |
| Plasma Siglec-5 levels are implicated as an early diagnostic marker of CLI in T2DM patients and it may become a target for the prevention or treatment of CLI in diabetes. | Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes.
Li JY, Yang XY, Wang XF, Jia X, Wang ZJ, Deng AP, Bai XL, Zhu L, Li BH, Feng ZB, Li Y, Wang L, Jin S., Free PMC Article | 06/22/2019 |
| PSGL1 and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general. | Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity.
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini EP, Bazaa A, Proulle V, Rupin A, Paysant J, Panicot-Dubois L, Christophe OD, Dubois C, Lenting PJ, Denis CV., Free PMC Article | 07/14/2018 |
| An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory. | Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.
Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A., Free PMC Article | 02/27/2016 |
| Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus. | Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A., Free PMC Article | 08/23/2014 |
| we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor. | Dectin-1 is essential for reverse transcytosis of glycosylated SIgA-antigen complexes by intestinal M cells.
Rochereau N, Drocourt D, Perouzel E, Pavot V, Redelinghuys P, Brown GD, Tiraby G, Roblin X, Verrier B, Genin C, Corthésy B, Paul S., Free PMC Article | 04/12/2014 |
| These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function. | Refolded recombinant Siglec5 for NMR investigation of complex carbohydrate binding.
Barb AW, Wang X, Prestegard JH., Free PMC Article | 08/31/2013 |
| Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees. | Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells.
Soto PC, Karris MY, Spina CA, Richman DD, Varki A., Free PMC Article | 08/3/2013 |
| Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. | Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.
Nordström T, Movert E, Olin AI, Ali SR, Nizet V, Varki A, Areschoug T., Free PMC Article | 11/26/2011 |
| Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes. | Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.
Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A., Free PMC Article | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival. | Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5.
Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V., Free PMC Article | 01/21/2010 |
| Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils. | The acute-phase protein alpha 1-acid glycoprotein (AGP) induces rises in cytosolic Ca2+ in neutrophil granulocytes via sialic acid binding immunoglobulin-like lectins (siglecs).
Gunnarsson P, Levander L, Påhlsson P, Grenegård M. | 01/21/2010 |
| Structural implications of SIGLEC5-mediated sialoglycan recognition are reported. | Structural implications of Siglec-5-mediated sialoglycan recognition.
Zhuravleva MA, Trandem K, Sun PD., Free PMC Article | 01/21/2010 |
| The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors. | Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.
Biedermann B, Gil D, Bowen DT, Crocker PR. | 01/21/2010 |
| Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation. | Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.
Avril T, Freeman SD, Attrill H, Clarke RG, Crocker PR. | 01/21/2010 |
| expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure. | Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes.
Erickson-Miller CL, Freeman SD, Hopson CB, D'Alessio KJ, Fischer EI, Kikly KK, Abrahamson JA, Holmes SD, King AG. | 01/21/2010 |
| Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5. | Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M. | 01/21/2010 |