| Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis. | Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.
Hutchenreuther J, Nguyen J, Quesnel K, Vincent KM, Petitjean L, Bourgeois S, Boyd M, Bou-Gharios G, Postovit LM, Leask A., Free PMC Article | 02/29/2024 |
| Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study. | Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.
Li LP, Li HX, Zhou H, Li WY, Wang RL, Zhang YC, Ma Y. | 11/27/2023 |
| Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis. | Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis.
Li Z, Li Q, Chen Z. | 07/13/2023 |
| Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients. | Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.
Saffari M, Rahimzada M, Mirhosseini A, Ghezaldasht SA, Valizadeh N, Moshfegh M, Moradi MT, Rezaee SA. | 09/3/2022 |
| CCNA2 as an Immunological Biomarker Encompassing Tumor Microenvironment and Therapeutic Response in Multiple Cancer Types. | CCNA2 as an Immunological Biomarker Encompassing Tumor Microenvironment and Therapeutic Response in Multiple Cancer Types.
Jiang A, Zhou Y, Gong W, Pan X, Gan X, Wu Z, Liu B, Qu L, Wang L., Free PMC Article | 04/30/2022 |
| E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity. | E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity.
Lu Y, Su F, Yang H, Xiao Y, Zhang X, Su H, Zhang T, Bai Y, Ling X. | 04/9/2022 |
| Identification of LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma. | Identification of LINC00665-miR-let-7b-CCNA2 competing endogenous RNA network associated with prognosis of lung adenocarcinoma.
Huang Y, Zhong L, Nie K, Li L, Song S, Liu F, Li P, Cao D, Liu Y., Free PMC Article | 12/18/2021 |
| PTEN Loss and Cyclin A2 Upregulation Define a PI3K/AKT Pathway Activation in Helicobacter pylori-induced MALT and DLBCL Gastric Lymphoma With Features of MALT. | PTEN Loss and Cyclin A2 Upregulation Define a PI3K/AKT Pathway Activation in Helicobacter pylori-induced MALT and DLBCL Gastric Lymphoma With Features of MALT.
Ben Younes K, Doghri R, Mrad K, Bedhiafi W, Benammar-Elgaaied A, Sola B, Ben Aissa-Fennira F. | 10/16/2021 |
| Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer. | Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.
Guo Y, Gabola M, Lattanzio R, Paul C, Pinet V, Tang R, Turali H, Bremond J, Longobardi C, Maurizy C, Da Costa Q, Finetti P, Boissière-Michot F, Rivière B, Lemmers C, Garnier S, Bertucci F, Zlobec I, Chebli K, Tazi J, Azar R, Blanchard JM, Sicinski P, Mamessier E, Lemmers B, Hahne M., Free PMC Article | 09/25/2021 |
| Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1. | Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1.
Silva Cascales H, Burdova K, Middleton A, Kuzin V, Müllers E, Stoy H, Baranello L, Macurek L, Lindqvist A., Free PMC Article | 09/18/2021 |
| Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization. | Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization.
Matsumoto N, Nemoto-Sasaki Y, Oka S, Arai S, Wada I, Yamashita A., Free PMC Article | 08/28/2021 |
| Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer. | Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer.
Xing Z, Wang X, Liu J, Zhang M, Feng K, Wang X., Free PMC Article | 05/22/2021 |
| CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. | CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.
Fu H, Zhang Y, Chen Y, Chen J, Chen P., Free PMC Article | 05/15/2021 |
| Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. | Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
Salamina M, Montefiore BC, Liu M, Wood DJ, Heath R, Ault JR, Wang LZ, Korolchuk S, Baslé A, Pastok MW, Reeks J, Tatum NJ, Sobott F, Arold ST, Pagano M, Noble MEM, Endicott JA., Free PMC Article | 05/8/2021 |
| Expression patterns and prognostic values of the cyclin-dependent kinase 1 and cyclin A2 gene cluster in pancreatic adenocarcinoma. | Expression patterns and prognostic values of the cyclin-dependent kinase 1 and cyclin A2 gene cluster in pancreatic adenocarcinoma.
Jiang P, Zhang M, Gui L, Zhang K., Free PMC Article | 05/1/2021 |
| Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway. | Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway.
Du LJ, Mao LJ, Jing RJ. | 03/20/2021 |
| miR5083p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7. | miR‑508‑3p suppresses the development of ovarian carcinoma by targeting CCNA2 and MMP7.
Guo F, Zhang K, Li M, Cui L, Liu G, Yan Y, Tian W, Teng F, Zhang Y, Gao C, Gao J, Wang Y, Xue F., Free PMC Article | 03/13/2021 |
| Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. | Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage.
Li X, Ma XL, Tian FJ, Wu F, Zhang J, Zeng WH, Lin Y, Zhang Y. | 08/29/2020 |
| Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A. | Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A.
Beveridge R, Migas LG, Kriwacki RW, Barran PE., Free PMC Article | 08/29/2020 |
| The up-regulation of BUB1B, CCNA2, CDC20, CDK1, and WEE1 in tumor tissues are associated with worse overall survival and disease-free survival in pancreatic ductal adenocarcinoma and is correlated with advanced tumor stage and tumor development. | Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma.
Dong S, Huang F, Zhang H, Chen Q., Free PMC Article | 02/1/2020 |
| Cyclin A2 gene is overexpressed in osteosarcoma and associated with poor prognosis outcomes in osteosarcoma patients. | CDC20 and its downstream genes: potential prognosis factors of osteosarcoma.
Wu MS, Ma QY, Liu DD, Li XJ, Deng LJ, Li N, Shen J, Zhao Z, Chen JX. | 01/11/2020 |
| we have demonstrated that ESRP1 overexpression induces G1-phase cell cycle arrest via reducing the stability of the cyclin A2 mRNA. | ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability.
Chen ZH, Jing YJ, Yu JB, Jin ZS, Li Z, He TT, Su XZ., Free PMC Article | 01/11/2020 |
| Study identify a non-canonical D box (D2) that is critical for cyclin A2 ubiquitination in vitro and degradation in vivo. During the spindle assembly checkpoint (SAC), cyclin A2 is ubiquitinated by the repressed APC/C-MCC, mediated by the cooperative engagement of its KEN and D2 boxes, ABBA motif, and the cofactor Cks. Once the SAC is satisfied, cyclin A2 binds APC/C-Cdc20 through two mutually exclusive binding modes. | Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.
Zhang S, Tischer T, Barford D., Free PMC Article | 12/21/2019 |
| analyzed the gene expression of human osteosarcoma (OS) biopsy samples, revealing that miR-449a and miR-424 are both down-regulated, whereas cyclin A2 is significantly up-regulated in these OS samples | The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression.
Shekhar R, Priyanka P, Kumar P, Ghosh T, Khan MM, Nagarajan P, Saxena S., Free PMC Article | 12/14/2019 |
| DUB3 functions as a novel cyclin A regulator through maintaining cyclin A stability. | Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.
Hu B, Deng T, Ma H, Liu Y, Feng P, Wei D, Ling N, Li L, Qiu S, Zhang L, Peng B, Liu J, Ye M., Free PMC Article | 11/30/2019 |