| NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system. | NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system.
Daren L, Dan Y, Jinhong W, Chao L. | 01/15/2024 |
| Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells. | Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.
Pflug KM, Lee DW, McFadden K, Herrera L, Sitcheran R., Free PMC Article | 08/17/2023 |
| EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. | EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, Kir S. | 06/1/2023 |
| NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. | NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT., Free PMC Article | 12/24/2022 |
| Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis. | Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis.
Zhao YX, Mei H, Huang YX, Chen JQ. | 10/15/2022 |
| NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress. | NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress.
Kamradt ML, Jung JU, Pflug KM, Lee DW, Fanniel V, Sitcheran R., Free PMC Article | 09/18/2021 |
| Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome. | Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome.
Singh MK, Singh L, Pushker N, Chosdol K, Bakhshi S, Meel R, Sen S, Kashyap S. | 03/27/2021 |
| Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor small ka, Cyrillicb Activation in Preeclampsia. | Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia.
Sakowicz A, Bralewska M, Pietrucha T, Habrowska-Górczyńska DE, Piastowska-Ciesielska AW, Gach A, Rybak-Krzyszkowska M, Witas PJ, Huras H, Grzesiak M, Biesiada L., Free PMC Article | 02/20/2021 |
| A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes. | A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes.
Feoktistova M, Makarov R, Brenji S, Schneider AT, Hooiveld GJ, Luedde T, Leverkus M, Yazdi AS, Panayotova-Dimitrova D., Free PMC Article | 02/13/2021 |
| Conditional Activation of NF-kappaB Inducing Kinase (NIK) in the Osteolineage Enhances Both Basal and Loading-Induced Bone Formation. | Conditional Activation of NF-κB Inducing Kinase (NIK) in the Osteolineage Enhances Both Basal and Loading-Induced Bone Formation.
Davis JL, Cox L, Shao C, Lyu C, Liu S, Aurora R, Veis DJ., Free PMC Article | 09/5/2020 |
| MiR-98-5p inhibits the secretion of hepatitis b virus (HBV), proliferation, migration, and invasion of HBV-hepatocellular carcinoma cells by targeting NIK. | MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF-κB-Inducing Kinase.
Fei X, Zhang P, Pan Y, Liu Y., Free PMC Article | 08/1/2020 |
| NF-kappaB-inducing kinase (NIK; also known as MAP3K14) -mediated alternative activation of canonical NF-kappaB signaling is a key driver of pathological inflammatory activation of human endothelial cells. | NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation.
Kucharzewska P, Maracle CX, Jeucken KCM, van Hamburg JP, Israelsson E, Furber M, Tas SW, Olsson HK. | 06/27/2020 |
| findings identify a NIK-SIX signalling axis that fine-tunes inflammatory gene expression programs under both physiological and pathological conditions | A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM., Free PMC Article | 12/7/2019 |
| Molecular dynamics simulations were employed to differentiate the structural dynamics of the NF-kappaB Inducing Kinase (NIK), a protein kinase responsible for invoking the non-canonical NF-kappaB pathway, in its native and mutant form, and in the absence and presence of salt concentration in efforts to probe whether changes in the ionic environment stabilize or destabilize the NIK dimer | Impact of intracellular ionic strength on dimer binding in the NF-kB Inducing kinase.
Jones MR, Yue J, Wilson AK. | 10/12/2019 |
| we identify nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB)-inducing kinase (NIK) as a potential drug target driving NF-kappaB signaling and Merlin-deficient schwannoma genesis | A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas.
Gehlhausen JR, Hawley E, Wahle BM, He Y, Edwards D, Rhodes SD, Lajiness JD, Staser K, Chen S, Yang X, Yuan J, Li X, Jiang L, Smith A, Bessler W, Sandusky G, Stemmer-Rachamimov A, Stuhlmiller TJ, Angus SP, Johnson GL, Nalepa G, Yates CW, Wade Clapp D, Park SJ., Free PMC Article | 06/22/2019 |
| Results indicated that MAP3K14 is a susceptibility gene for leprosy. | A pathway-based association analysis identified FMNL1-MAP3K14 as susceptibility genes for leprosy.
Zhang H, Wang Z, Fu X, Sun Y, Mi Z, Yu G, Sun L, Wang N, Wang C, Zhao Q, Pan Q, Yue Z, Liu H, Zhang F. | 03/23/2019 |
| A TRAF3-NIK axis differentially regulates viral DNA vs RNA pathways in innate immune signaling. | A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.
Parvatiyar K, Pindado J, Dev A, Aliyari SR, Zaver SA, Gerami H, Chapon M, Ghaffari AA, Dhingra A, Cheng G., Free PMC Article | 12/22/2018 |
| Data show that breast cancer stem cells (BCSCs) expressed higher levels of NF-kappaB-inducing kinase (NIK). | NF-kappaΒ-inducing kinase regulates stem cell phenotype in breast cancer.
Vazquez-Santillan K, Melendez-Zajgla J, Jimenez-Hernandez LE, Gaytan-Cervantes J, Muñoz-Galindo L, Piña-Sanchez P, Martinez-Ruiz G, Torres J, Garcia-Lopez P, Gonzalez-Torres C, Ruiz V, Avila-Moreno F, Velasco-Velazquez M, Perez-Tapia M, Maldonado V., Free PMC Article | 05/26/2018 |
| These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1. | NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion.
Jung JU, Ravi S, Lee DW, McFadden K, Kamradt ML, Toussaint LG, Sitcheran R., Free PMC Article | 01/27/2018 |
| results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. | The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. | 11/25/2017 |
| report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB signaling nodes TRAF2, TRAF3, IKKalpha, NIK, and NF-kappaB2/p100; also provide a differential interactome of NIK mutants that cause immunodeficiency | Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway.
Willmann KL, Sacco R, Martins R, Garncarz W, Krolo A, Knapp S, Bennett KL, Boztug K., Free PMC Article | 10/28/2017 |
| OLFM1 is a negative regulator of non-canonical NF-kappaB signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC) patients. | Olfactomedin 1 negatively regulates NF-κB signalling and suppresses the growth and metastasis of colorectal cancer cells.
Shi W, Ye Z, Zhuang L, Li Y, Shuai W, Zuo Z, Mao X, Liu R, Wu J, Chen S, Huang W. | 07/1/2017 |
| The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM stage. high OTUD7B/low NIK index can predict an good prognosis. | OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications.
Zhang B, Wang H, Yang L, Zhang Y, Wang P, Huang G, Zheng J, Ren H, Qin S. | 03/25/2017 |
| NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients. | Expression of NF-κB-inducing kinase in breast carcinoma tissue and its clinical significance.
Zhang X, Wang Y, Mao Z, Huang D, Zhou J, Wang X., Free PMC Article | 10/29/2016 |
| This study identified two novel independent loci (MAP3K14 and CARD9) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association. | Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans With Rheumatoid Arthritis.
Arya R, Del Rincon I, Farook VS, Restrepo JF, Winnier DA, Fourcaudot MJ, Battafarano DF, de Almeida M, Kumar S, Curran JE, Jenkinson CP, Blangero J, Duggirala R, Escalante A. | 09/3/2016 |