| ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation. | ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation.
Batbayar G, Ishimura A, Lyu H, Wanna-Udom S, Meguro-Horike M, Terashima M, Horike SI, Takino T, Suzuki T. | 06/16/2023 |
| CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis. | CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.
Li X, Qu M, Zhang J, Chen K, Ma X., Free PMC Article | 10/30/2021 |
| Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Lee YT, Ayoub A, Park SH, Sha L, Xu J, Mao F, Zheng W, Zhang Y, Cho US, Dou Y., Free PMC Article | 06/5/2021 |
| ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells. | ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells.
Constantin D, Widmann C., Free PMC Article | 05/1/2021 |
| Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization. | Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.
Kato H, Asamitsu K, Sun W, Kitajima S, Yoshizawa-Sugata N, Okamoto T, Masai H, Poellinger L. | 11/28/2020 |
| Our findings suggest that ASH2L participates in the promotion of endometrial cancer progression, if not totally at least partially, via upregulation of PAX2 transcription. | ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription.
Zeng K, Wu Y, Wang C, Wang S, Sun H, Zou R, Sun G, Song H, Liu W, Sun N, Wei S, Liu W, Su Y, Zhou T, Zhang Y, Zhao Y., Free PMC Article | 06/20/2020 |
| Circ-ASH2L served as a miRNA sponge for miR-34a and promoted tumor progression in vivo. Finally, we analyzed circ-ASH2L expression in clinical tissues and found that high circ-ASH2L expression was correlated with lymphatic invasion and TNM stage and was an independent risk factor for pancreatic patient survival. | Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma.
Chen Y, Li Z, Zhang M, Wang B, Ye J, Zhang Y, Tang D, Ma D, Jin W, Li X, Wang S., Free PMC Article | 05/16/2020 |
| unliganded glucocorticoid receptor and ASH2L may act as key regulatory players of BCL- XL upregulation in acute myeloid leukemia cells. | Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells.
Rocha-Viegas L, Silbermins M, Ogara MF, Pellegrini JM, Nuñez SY, García VE, Vicent GP, Pecci A. | 04/18/2020 |
| berrant histone methylation of IFN-gamma associating H3K4me3 and H3K27me3 caused by over-binding of Ash2L and Jmjd3 might be involved in immune dysfunction and vascular damage in Kawasaki disease in the acute phase. | [Role of ash2 (absent, small, or homeotic)-like and Jumonji domain-containing protein 3 on histone methylation of interferon-gamma gene and their associations with vascular damage of Kawasaki disease].
Mei JH, Tang G, Wang Q, Wen PQ, Xu MG, Cui D, Ma DL, Liu C, Wang GB. | 02/16/2019 |
| our results suggest that ASH2L contributes to leukemogenesis by cooperating with other proteins that aberrantly upregulate cellular growth and proliferation pathways. | Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.
Butler JS, Qiu YH, Zhang N, Yoo SY, Coombes KR, Dent SY, Kornblau SM., Free PMC Article | 01/13/2018 |
| different cancer mutations in MLL1 lead to a loss or increase in activity, illustrating the complex and tumor-specific role of MLL1 in carcinogenesis. | Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.
Weirich S, Kudithipudi S, Jeltsch A., Free PMC Article | 11/4/2017 |
| Overall, epigenetic modulation is a promising approach to evaluate the role of chromatin structure for the radioresponsiveness of glioma cell lines. | Epigenetic silencing and activation of transcription: influence on the radiation sensitivity of glioma cell lines.
Sak A, Kübler D, Bannik K, Groneberg M, Strunz S, Kriehuber R, Stuschke M. | 08/19/2017 |
| Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha) induced proinflammatory transcription in macrophages. | MKL1 is an epigenetic mediator of TNF-α-induced proinflammatory transcription in macrophages by interacting with ASH2.
Song M, Fang F, Dai X, Yu L, Fang M, Xu Y. | 06/3/2017 |
| the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment | EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.
Erfani P, Tome-Garcia J, Canoll P, Doetsch F, Tsankova NM., Free PMC Article | 03/12/2016 |
| Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation. | Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.
Mungamuri SK, Wang S, Manfredi JJ, Gu W, Aaronson SA., Free PMC Article | 08/1/2015 |
| ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers | Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3).
Qi J, Huo L, Zhu YT, Zhu YJ., Free PMC Article | 01/24/2015 |
| Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L heterodimer. | A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
Shinsky SA, Hu M, Vought VE, Ng SB, Bamshad MJ, Shendure J, Cosgrove MS., Free PMC Article | 07/12/2014 |
| Data indicate that MLL1 methylates Ash2L in the absence of histone H3, but only when assembled within a complex with WDR5 and RbBP5. | Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS., Free PMC Article | 04/12/2014 |
| H2B dependent regulation of MLL family histone methylatransferases depends on the N-terminal WH motif of ASH2L. | ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes.
Wu L, Lee SY, Zhou B, Nguyen UT, Muir TW, Tan S, Dou Y., Free PMC Article | 05/25/2013 |
| crystal structure of the C-terminal SPRY domain of human Ash2L | Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Chen Y, Cao F, Wan B, Dou Y, Lei M., Free PMC Article | 07/14/2012 |
| The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity. | Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M., Free PMC Article | 01/14/2012 |
| ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. | Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.
Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF., Free PMC Article | 09/10/2011 |
| NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L | NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.
Fossati A, Dolfini D, Donati G, Mantovani R., Free PMC Article | 08/6/2011 |
| Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. | Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.
Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY., Free PMC Article | 07/23/2011 |
| Data suggest that both Ash2L/RbBP5 and the MLL1 SET domain make direct contacts with the substrates and contribute to the formation of a joint catalytic center. | An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y., Free PMC Article | 04/30/2011 |