| circ_SIRT1 upregulates ATG12 to facilitate Imatinib resistance in CML through interacting with EIF4A3. | circ_SIRT1 upregulates ATG12 to facilitate Imatinib resistance in CML through interacting with EIF4A3.
Zhang R, Hao J, Yu H, Wang ZJ, Lan F, Peng Y, Qiu Y. | 11/21/2023 |
| ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer. | ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer.
Keulers TG, Koch A, van Gisbergen MW, Barbeau LMO, Zonneveld MI, de Jong MC, Savelkouls KGM, Wanders RG, Bussink J, Melotte V, Rouschop KMA., Free PMC Article | 08/6/2022 |
| Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers. | Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.
Zhang S, Liu X, Abdulmomen Ali Mohammed S, Li H, Cai W, Guan W, Liu D, Wei Y, Rong D, Fang Y, Haider F, Lv H, Jin Z, Chen X, Mo Z, Li L, Yang S, Wang H., Free PMC Article | 08/6/2022 |
| LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis. | LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis.
Dai H, Wang J, Huang Z, Zhang H, Wang X, Li Q, Feng W., Free PMC Article | 03/12/2022 |
| Toxoplasma gondii profilin and tachyzoites RH strain may manipulate autophagy via downregulating Atg5 and Atg12 and upregulating Atg7. | Toxoplasma gondii profilin and tachyzoites RH strain may manipulate autophagy via downregulating Atg5 and Atg12 and upregulating Atg7.
Nemati S, Pazoki H, Mohammad Rahimi H, Asadzadeh Aghdaei H, Shahrokh S, Baghaei K, Mirjalali H, Zali MR. | 01/29/2022 |
| LncRNA KCNQ1OT1 as a miR-26a-5p sponge regulates ATG12-mediated cardiomyocyte autophagy and aggravates myocardial infarction. | LncRNA KCNQ1OT1 as a miR-26a-5p sponge regulates ATG12-mediated cardiomyocyte autophagy and aggravates myocardial infarction.
Li J, Tong Y, Zhou Y, Han Z, Wang X, Ding T, Qu Y, Zhang Z, Chang C, Zhang X, Qiu C. | 09/18/2021 |
| ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics. | ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
Liu H, He Z, Germič N, Ademi H, Frangež Ž, Felser A, Peng S, Riether C, Djonov V, Nuoffer JM, Bovet C, Mlinarič-Raščan I, Zlobec I, Fiedler M, Perren A, Simon HU., Free PMC Article | 09/11/2021 |
| BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. | BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells.
Lin TY, Chan HH, Chen SH, Sarvagalla S, Chen PS, Coumar MS, Cheng SM, Chang YC, Lin CH, Leung E, Cheung CHA., Free PMC Article | 07/31/2021 |
| PTBP3 promotes malignancy and hypoxia-induced chemoresistance in pancreatic cancer cells by ATG12 up-regulation. | PTBP3 promotes malignancy and hypoxia-induced chemoresistance in pancreatic cancer cells by ATG12 up-regulation.
Ma J, Weng L, Jia Y, Liu B, Wu S, Xue L, Yin X, Mao A, Wang Z, Shang M., Free PMC Article | 04/24/2021 |
| WASF3 silencing promotes proliferation, migration and invasiveness of gastric cancer cells; its knockdown depended on the inhibition of Atg12-mediated autophagy | WASF3 Knockdown Sensitizes Gastric Cancer Cells to Oxaliplatin by Inhibiting ATG12-Mediated Autophagy.
Nie Y, Liang X, Liu S, Guo F, Fang N, Zhou F. | 07/18/2020 |
| Results show that ATG12 levels were consistently higher in glioma tissues. In addition, ATG12 is found as a target gene of miR-454 by bioinformatic analysis. | miR-454-3p Is an Exosomal Biomarker and Functions as a Tumor Suppressor in Glioma.
Shao N, Xue L, Wang R, Luo K, Zhi F, Lan Q. | 11/30/2019 |
| These results suggested that ATG12 expression quantitative trait loci SNP rs26537 might contribute to an allele-specific effect on the expression of host gene ATG12 and explain a fraction of head and neck squamous cell carcinoma genetic susceptibility. | ATG12 expression quantitative trait loci associated with head and neck squamous cell carcinoma risk in a Chinese Han population.
Song X, Yuan Z, Yuan H, Wang L, Ji P, Jin G, Dai J, Ma H. | 03/30/2019 |
| this study identified a novel mechanism by which oncogenic RAS promotes survival of malignant intestinal epithelial cells. This mechanism is driven by RAS-dependent loss of ATG12 in these cells. | Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Yoo BH, Khan IA, Koomson A, Gowda P, Sasazuki T, Shirasawa S, Gujar S, Rosen KV., Free PMC Article | 03/2/2019 |
| miR-23a downregulation modulates the inflammatory response by targeting ATG12-mediated autophagy. | miR‑23a downregulation modulates the inflammatory response by targeting ATG12‑mediated autophagy.
Si X, Cao D, Chen J, Nie Y, Jiang Z, Chen MY, Wu JF, Guan XD., Free PMC Article | 11/3/2018 |
| the role of the autophagy elongation complex (ATG5-12/16L1) in Hepatitis C virus replication and membranous web formation, was examined. | The autophagy elongation complex (ATG5-12/16L1) positively regulates HCV replication and is required for wild-type membranous web formation.
Fahmy AM, Labonté P., Free PMC Article | 10/20/2018 |
| Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to epirubicin. Regulatory effect of Ambra1 on epirubicin sensitivity is achieved through the regulation of autophagy by targeting ATG12. | Ambra1 modulates the sensitivity of breast cancer cells to epirubicin by regulating autophagy via ATG12.
Sun WL, Wang L, Luo J, Zhu HW, Cai ZW., Free PMC Article | 10/13/2018 |
| The finding that miR378 targets ATG12 indicated that miR378 may have a potential role in autophagy. These findings may provide novel insights into the mechanism of metastasis in cervical cancer and a novel therapeutic target for the treatment of cervical cancer. | MicroRNA-378 enhances migration and invasion in cervical cancer by directly targeting autophagy-related protein 12.
Tan D, Zhou C, Han S, Hou X, Kang S, Zhang Y., Free PMC Article | 09/15/2018 |
| Results show that ATG12 is a downstream effector in MALAT1-mediated autophagy in gastric cancer cells. | Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer.
YiRen H, YingCong Y, Sunwu Y, Keqin L, Xiaochun T, Senrui C, Ende C, XiZhou L, Yanfan C., Free PMC Article | 07/21/2018 |
| HBV gained access to Atg5-12/16L1 via interaction of its core protein with the Atg12 moiety of the complex. In contrast, subsequent autophagosome maturation and closure events were unnecessary for HBV replication, as evidenced by inhibition of Atg8/LC3 conjugation. Interfering with the HBV/Atg12 cross talk may be a tool for virus control. | Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation.
Döring T, Zeyen L, Bartusch C, Prange R., Free PMC Article | 04/21/2018 |
| transcriptional activity of ATG12 gene promoter was not significantly affected by other two DNA sequence variants identified in Parkinson's disease patient | Novel and functional ATG12 gene variants in sporadic Parkinson's disease.
Li Y, Huang J, Pang S, Wang H, Zhang A, Hawley RG, Yan B. | 12/23/2017 |
| STAT3 and ATG12 are targets of miR-454-3p. | Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth.
Bao X, Ren T, Huang Y, Sun K, Wang S, Liu K, Zheng B, Guo W., Free PMC Article | 11/4/2017 |
| above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro). | Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3C(pro).
Fan X, Han S, Yan D, Gao Y, Wei Y, Liu X, Liao Y, Guo H, Sun S., Free PMC Article | 10/28/2017 |
| rs26538 was relevant to the lower risk of coal workers' pneumoconiosis and conferred to reduce the transcription activity of ATG12's promoter. | Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population.
Yuan J, Han R, Esther A, Wu Q, Yang J, Yan W, Ji X, Liu Y, Li Y, Yao W, Ni C. | 10/7/2017 |
| ATG5-ATG12 is increased in hepatitis B virus-associated hepatocellular carcinoma and has a role in apoptosis | Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis.
Kunanopparat A, Kimkong I, Palaga T, Tangkijvanich P, Sirichindakul B, Hirankarn N., Free PMC Article | 05/20/2017 |
| Analysis of hepatitis B virus capsid maturation steps revealed that Rab33B and Atg5/12/16L1 are required for proper particle assembly and/or stability. | Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release.
Döring T, Prange R. | 01/2/2016 |