The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells. | The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells. Wang J, Cheng X, Mei X, Wu H, Yu Q, Xiao M. | 01/10/2024 |
TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis. | TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis. Kim KM, Yoo GD, Heo W, Oh HT, Park J, Shin S, Do Y, Jeong MG, Hwang ES, Hong JH., Free PMC Article | 01/6/2024 |
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. | Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. Valdivia A, Cárdenas A, Brenet M, Maldonado H, Kong M, Díaz J, Burridge K, Schneider P, San Martín A, García-Mata R, Quest AFG, Leyton L., Free PMC Article | 08/14/2021 |
Loss of endothelial PAR-3 disrupts regional axial cell polarity and increases pro-inflammatory response of endothelial cells. | PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow. Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M., Free PMC Article | 06/8/2019 |
mammary morphogenesis is dependent on the ability of Par3 to directly bind aPKC | The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. McCaffrey LM, Macara IG., Free PMC Article | 05/13/2019 |
The structure of par3-PDZ3 peptide bound to the C-terminal tail of vascular endothelial cadherin clearly shows that both canonical and distal interactions are utilized in binding and suggests a mechanism for ligand specificity within the polarity network. | Distal interactions within the par3-VE-cadherin complex. Tyler RC, Peterson FC, Volkman BF., Free PMC Article | 05/13/2019 |
results suggest that ERK2 phosphorylates Par3 and inhibits its binding with KIF3A, thereby controlling Par3 transport and neuronal polarity | ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. Funahashi Y, Namba T, Fujisue S, Itoh N, Nakamuta S, Kato K, Shimada A, Xu C, Shan W, Nishioka T, Kaibuchi K., Free PMC Article | 05/13/2019 |
Polycystin-1 binds Par3/PKCalpha and controls convergent extension during renal tubular morphogenesis. | Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Castelli M, Boca M, Chiaravalli M, Ramalingam H, Rowe I, Distefano G, Carroll T, Boletta A., Free PMC Article | 05/13/2019 |
Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation. | Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway. Yang R, Kong E, Jin J, Hergovich A, Püschel AW., Free PMC Article | 05/13/2019 |
support for the hitherto untested model that Par3-mInsc and Galphai3 act cooperatively to polarize LGN and promote perpendicular divisions | Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E., Free PMC Article | 05/13/2019 |
this study demonstrates a mechanism by which loss of Par3 promotes proliferation and tumorigenesis, which supports a tumor-suppressive function for Par3 in the mammary epithelium. | Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3. Archibald A, Mihai C, Macara IG, McCaffrey L., Free PMC Article | 05/13/2019 |
Loss of PAR3 triggers increased production of interleukin-6, which induces STAT3 signaling in an autocrine manner. | Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells. Guyer RA, Macara IG., Free PMC Article | 05/13/2019 |
Par3 is the long-sought exocyst receptor required for targeted membrane-protein delivery. | The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Ahmed SM, Macara IG., Free PMC Article | 05/13/2019 |
Epidermal aPKClambda and Par3 promote a tumor-permissive environment. | Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis. Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S., Free PMC Article | 05/13/2019 |
Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes | Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes. Zhou PJ, Wang X, An N, Wei L, Zhang L, Huang X, Zhu HH, Fang YX, Gao WQ. | 05/13/2019 |
radial glial progenitor behavior and cortical development are controlled by temporally distinct actions of partitioning-defective 3 (PARD3) in concert with dynamic HIPPO signaling | PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia. Liu WA, Chen S, Li Z, Lee CH, Mirzaa G, Dobyns WB, Ross ME, Zhang J, Shi SH., Free PMC Article | 08/11/2018 |
Par3A function is either dispensable for slit diaphragm integrity, or compensatory mechanisms and a high redundancy of the different polarity proteins | Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT. | 07/22/2017 |
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation. | Par-3 modulates intestinal epithelial barrier function through regulating intracellular trafficking of occludin and myosin light chain phosphorylation. Yu M, Yang S, Qiu Y, Chen G, Wang W, Xu C, Cai W, Sun L, Xiao W, Yang H. | 08/20/2016 |
HTT is required for the apical localization of PAR3-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice. | Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC. Elias S, McGuire JR, Yu H, Humbert S., Free PMC Article | 04/16/2016 |
Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 substrate and demonstrate that Smek1 suppresses its activity. | Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells. Lyu J, Kim HR, Yamamoto V, Choi SH, Wei Z, Joo CK, Lu W., Free PMC Article | 08/30/2014 |
Par3 (and protein kinase C zeta) are activated in neurons when binding to N2-proteoglygan. | Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition. Lee SI, Zhang W, Ravi M, Weschenfelder M, Bastmeyer M, Levine JM., Free PMC Article | 04/6/2013 |
Suggest that loss of Par3 promotes metastatic behaviour of ErbB2-induced breast tumour epithelial cells by decreasing cell-cell cohesion. | Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK., Free PMC Article | 03/30/2013 |
Par3 is identified as a regulator of signaling pathways relevant to invasive breast cancer. | Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. McCaffrey LM, Montalbano J, Mihai C, Macara IG., Free PMC Article | 01/26/2013 |
The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3. | Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3. Cadot B, Gache V, Vasyutina E, Falcone S, Birchmeier C, Gomes ER., Free PMC Article | 11/17/2012 |
Data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification. | aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. Iden S, Misselwitz S, Peddibhotla SS, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K., Free PMC Article | 06/9/2012 |