| This study evaluated the occurrence of a variant of UCP4 in patients with frontotemporal dementia, Parkinson disease, and healthy controls. | Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia.
Montesanto A, Crocco P, Dato S, Geracitano S, Frangipane F, Colao R, Maletta R, Passarino G, Bruni AC, Rose G., Free PMC Article | 12/28/2019 |
| our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress | Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
Xu S, Yang X, Qian Y, Xiao Q. | 05/11/2019 |
| This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease. | The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.
Montesanto A, Crocco P, Anfossi M, Smirne N, Puccio G, Colao R, Maletta R, Passarino G, Bruni AC, Rose G. | 12/31/2016 |
| UCP4 mRNA of cartilage tissues was decreased in osteoarthritis patients, which was negatively correlated with synovial fluid (SF) leptin concentration. | Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis.
Huang Z, Li J, Du S, Chen G, Qi Y, Huang L, Xiao L, Tong P., Free PMC Article | 07/30/2016 |
| Compares and contrasts all the known human SLC25A* genes and includes functional information. | The mitochondrial transporter family SLC25: identification, properties and physiopathology.
Palmieri F. | 07/2/2013 |
| UCP4 is a target effector gene of the NF-kappaB c-Rel prosurvival pathway to mitigate the effects of oxidative stress. | UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress.
Ho JW, Ho PW, Liu HF, So DH, Chan KH, Tse ZH, Kung MH, Ramsden DB, Ho SL. | 12/22/2012 |
| Neuronal UCP4 exhibits transmembrane chloride transport activity. | Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
Hoang T, Smith MD, Jelokhani-Niaraki M. | 08/25/2012 |
| Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II. | Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.
Ho PW, Ho JW, Tse HM, So DH, Yiu DC, Liu HF, Chan KH, Kung MH, Ramsden DB, Ho SL., Free PMC Article | 06/23/2012 |
| UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor expression, and positivity for p53 and Ki-67 in breast carcinomas. | Mitochondrial UCP4 and bcl-2 expression in imprints of breast carcinomas: relationship with DNA ploidy and classical prognostic factors.
Gonidi M, Athanassiadou AM, Patsouris E, Tsipis A, Dimopoulos S, Kyriakidou V, Chelidonis G, Athanassiadou P. | 10/15/2011 |
| A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.( | A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.
Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. | 07/30/2011 |
| the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia. | Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia.
Mouaffak F, Kebir O, Bellon A, Gourevitch R, Tordjman S, Viala A, Millet B, Jaafari N, Olié JP, Krebs MO. | 06/18/2011 |
| has a significant role in NF-kappaB-mediated prosurvival signaling and cell protection against neurotoxins | Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.
Ho JW, Ho PW, Zhang WY, Liu HF, Kwok KH, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL. | 04/23/2011 |
| overexpression increases neural cell survival by inducing oxidative phosphorylation, preserving ATP synthesis and mitochondrial membrane potential, and reducing oxidative stress. | Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression.
Chu AC, Ho PW, Kwok KH, Ho JW, Chan KH, Liu HF, Kung MH, Ramsden DB, Ho SL. | 01/21/2010 |
| Data describe how variants of mitochondrial uncoupling protein 4 (mUCP4) may contibute to development of multiple sclerosis, since mUCP4 is presumed to be of importance in regulation of the mitochondrial membrane potential and cellular energy metabolism. | A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis.
Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.
Yasuno K, Ando S, Misumi S, Makino S, Kulski JK, Muratake T, Kaneko N, Amagane H, Someya T, Inoko H, Suga H, Kanemoto K, Tamiya G, Yasuno K, Ando S, Misumi S, Makino S, Kulski JK, Muratake T, Kaneko N, Amagane H, Someya T, Inoko H, Suga H, Kanemoto K, Tamiya G. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.
Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis.
Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F, Szolnoki Z, Kondacs A, Mandi Y, Bodor A, Somogyvari F. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ. Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.
Lee HJ, Ryu HJ, Shin HD, Park BL, Kim JY, Cho YM, Park KS, Song J, Oh B. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Norberg A, Forsgren L, Holmberg D, Holmberg M. | 03/13/2008 |
| The stabilization of Ca(2+) homeostasis and preservation of mitochondrial function by UCP4 was correlated with reduced mitochondrial reactive oxygen species generation and oxidative stress. | Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells.
Chan SL, Liu D, Kyriazis GA, Bagsiyao P, Ouyang X, Mattson MP. | 01/21/2010 |
| These findings suggest that UCP2 and UCP4 have a modest but important involvement in the genetic etiology of schizophrenia. | Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.
Yasuno K, Ando S, Misumi S, Makino S, Kulski JK, Muratake T, Kaneko N, Amagane H, Someya T, Inoko H, Suga H, Kanemoto K, Tamiya G, Yasuno K, Ando S, Misumi S, Makino S, Kulski JK, Muratake T, Kaneko N, Amagane H, Someya T, Inoko H, Suga H, Kanemoto K, Tamiya G. | 01/21/2010 |
| Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. | Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP. | 01/21/2010 |