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    CREB5 cAMP responsive element binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 9586, updated on 9-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis.

    Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis.
    Wu Z, Wang X, Wu H, Du S, Wang Z, Xie S, Zhang R, Chen G, Chen H.

    04/27/2024
    Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.

    Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.
    Zhou R, Zhao L, Wang Q, Cheng Y, Song M, Huang C., Free PMC Article

    04/3/2024
    SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.

    SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
    Gong DA, Zhou P, Chang WY, Yang JY, Zhang YL, Huang AL, Tang N, Wang K.

    01/17/2024
    The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.

    The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
    Dai W, Hong L, Xiao W, Zhang L, Sha W, Yu Z, Liu X, Liu S, Xiao Y, Yang P, Peng Y, Zhang J, Lin J, Wu X, Tang W, Lin Z, Xiang L, Li J, Pei M, Wang J., Free PMC Article

    11/2/2023
    Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.

    Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
    Shi W, Le W, Tang Q, Shi S, Shi J., Free PMC Article

    06/23/2023
    Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.

    Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
    Qiu J, Wang P, Chen Z, Zhou Y, Zhang G, Wang Z, Wu J, Zhu Q, Jiang C., Free PMC Article

    05/4/2023
    microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.

    microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.
    Chi Y, Gong Z, Xin H, Wang Z, Liu Z., Free PMC Article

    12/3/2022
    The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.

    The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
    Li J, Yang J, Yu Q, Chen L, Shi X, Su J, Zhu K., Free PMC Article

    10/15/2022
    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies.

    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies.
    Hwang JH, Arafeh R, Seo JH, Baca SC, Ludwig M, Arnoff TE, Sawyer L, Richter C, Tape S, Bergom HE, McSweeney S, Rennhack JP, Klingenberg SA, Cheung ATM, Kwon J, So J, Kregel S, Van Allen EM, Drake JM, Freedman ML, Hahn WC., Free PMC Article

    06/11/2022
    Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank.

    Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank.
    Yanik EL, Keener JD, Lin SJ, Colditz GA, Wright RW, Evanoff BA, Jain NB, Saccone NL., Free PMC Article

    11/27/2021
    Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.

    Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.
    Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, Burgess JD, Ertekin-Taner N, Petersen RC, Wang L, Qi Z, He A, Neuhaus I, Patel V, Foroud T, Faber KM, Lovestone S, Simmons A, Weiner MW, Saykin AJ, Alzheimer's Disease Neuroimaging Initiative., Free PMC Article

    11/22/2021
    Whole-exome sequencing reveals common and rare variants in immunologic and neurological genes implicated in achalasia.

    Whole-exome sequencing reveals common and rare variants in immunologic and neurological genes implicated in achalasia.
    Li Q, Chen W, Wang C, Liu Z, Gu Y, Xu X, Xu J, Jiang T, Xu M, Wang Y, Chen C, Zhong Y, Zhang Y, Yao L, Jin G, Hu Z, Zhou P., Free PMC Article

    09/4/2021
    CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET.

    CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET.
    Wang S, Qiu J, Liu L, Su C, Qi L, Huang C, Chen X, Zhang Y, Ye Y, Ding Y, Liang L, Liao W., Free PMC Article

    06/12/2021
    CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer.

    CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer.
    Hwang JH, Seo JH, Beshiri ML, Wankowicz S, Liu D, Cheung A, Li J, Qiu X, Hong AL, Botta G, Golumb L, Richter C, So J, Sandoval GJ, Giacomelli AO, Ly SH, Han C, Dai C, Pakula H, Sheahan A, Piccioni F, Gjoerup O, Loda M, Sowalsky AG, Ellis L, Long H, Root DE, Kelly K, Van Allen EM, Freedman ML, Choudhury AD, Hahn WC., Free PMC Article

    09/26/2020
    High CREB5 expression is associated with proliferation, metastasis and migration of colorectal cancer.

    LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5.
    Zhang M, Li Y, Wang H, Yu W, Lin S, Guo J., Free PMC Article

    07/4/2020
    These data highlights a role of CREB5 involved in the pathogenesis of recurrent pregnancy loss.

    Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss.
    Yu M, Du G, Xu Q, Huang Z, Huang X, Qin Y, Han L, Fan Y, Zhang Y, Han X, Jiang Z, Xia Y, Wang X, Lu C., Free PMC Article

    01/26/2019
    The results indicated that epigenetically regulated miR-449a targets CREB5 to increase FXRalpha expression, thereby promoting HBV replication and gene expression. Our findings provide a new understanding of the role of miRNAs in HBV replication

    Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype.
    Zhang X, Liu H, Xie Z, Deng W, Wu C, Qin B, Hou J, Lu M., Free PMC Article

    02/3/2018
    High CREB5 expression is associated with triple-negative breast cancer.

    Regulation of miRNA-29c and its downstream pathways in preneoplastic progression of triple-negative breast cancer.
    Bhardwaj A, Singh H, Rajapakshe K, Tachibana K, Ganesan N, Pan Y, Gunaratne PH, Coarfa C, Bedrosian I., Free PMC Article

    10/14/2017
    LOC401317 is directly regulated by p53. Ectopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo.

    LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2.
    Gong Z, Zhang S, Zeng Z, Wu H, Yang Q, Xiong F, Shi L, Yang J, Zhang W, Zhou Y, Zeng Y, Li X, Xiang B, Peng S, Zhou M, Li X, Tan M, Li Y, Xiong W, Li G., Free PMC Article

    06/13/2017
    CREB5 accelerate the metastasis of colorectal cancer by regulating these five key genes.

    Involvement of the CREB5 regulatory network in colorectal cancer metastasis.
    Qi L, Ding Y.

    02/17/2015
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    02/17/2015
    Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
    Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article

    02/17/2015
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
    Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, Trent JM, Duggan D, Carpten J, Grönberg H, Isaacs WB.

    Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C.

    02/17/2015
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