| The molecular mechanisms of human separase regulation. | The molecular mechanisms of human separase regulation.
Yu J, Morgan DO, Boland A., Free PMC Article | 06/29/2023 |
| [Separase, a key-player of mitosis: A new target for cancer therapy?]", trans "La separase, proteine-cle de la mitose - Une nouvelle cible therapeutique anti-cancereuse ? | [Separase, a key-player of mitosis: A new target for cancer therapy?].
Aouadi E, Fornier M, Gosseye A, Castillo-Ferrer C, Frachet V. | 02/5/2022 |
| Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study. | Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Wang R, Zang W, Hu B, Deng D, Ling X, Zhou H, Su M, Jiang J., Free PMC Article | 11/27/2021 |
| Structural basis of human separase regulation by securin and CDK1-cyclin B1. | Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A., Free PMC Article | 09/4/2021 |
| Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants. | Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
Miller JB, Ward E, Staley LA, Stevens J, Teerlink CC, Tavana JP, Cloward M, Page M, Dayton L, Alzheimer's Disease Genetics Consortium, Cannon-Albright LA, Kauwe JSK., Free PMC Article | 08/7/2021 |
| TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. | TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Yang Q, Yu B, Sun J., Free PMC Article | 05/8/2021 |
| results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the spindle assembly checkpoint | Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.
Hellmuth S, Gómez-H L, Pendás AM, Stemmann O. | 06/6/2020 |
| human cells that enter mitosis with already active separase rapidly undergo death in mitosis owing to direct cleavage of anti-apoptotic MCL1 and BCL-XL by separase; separase-triggered apoptosis enforces minimal length of mitosis | Separase-triggered apoptosis enforces minimal length of mitosis.
Hellmuth S, Stemmann O. | 06/6/2020 |
| data suggests an association between high separase activity, residual BCR-ABL1 gene expression, and enhanced proliferative capacity in hematopoietic cells within the leukemic niche of TKI-treated chronic phase CML. | Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients.
Spiess B, Kleiner H, Flach J, Fabarius A, Saussele S, Hofmann WK, Seifarth W., Free PMC Article | 05/16/2020 |
| LPE motif on the Scc1 substrate is required for rapid and specific cleavage by separase. | Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.
Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO., Free PMC Article | 03/14/2020 |
| Thus, tethering of separase to DSBs and confined cohesin cleavage promote DSB repair in G2 cells. Importantly, this conserved interphase function of separase protects mammalian cells from oncogenic transformation. | Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Hellmuth S, Gutiérrez-Caballero C, Llano E, Pendás AM, Stemmann O., Free PMC Article | 10/5/2019 |
| Separase activity measurement may therefore be useful as a novel additional molecular marker for disease monitoring | Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Ruppenthal S, Kleiner H, Nolte F, Fabarius A, Hofmann WK, Nowak D, Seifarth W., Free PMC Article | 03/17/2018 |
| Studies identified and characterized the role of separase in mitosis, meiosis, non-canonical roles, its regulation, as a regulator of centriole disengagement, non proteolytic roles, diverse substrates, structural insights, and association of separase with cancer. [review] | Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene.
Kumar R. | 12/2/2017 |
| High ESP expression is associated with breast cancer. | Separase is a marker for prognosis and mitotic activity in breast cancer.
Gurvits N, Löyttyniemi E, Nykänen M, Kuopio T, Kronqvist P, Talvinen K., Free PMC Article | 11/11/2017 |
| Proximity mapping of human separase has been presented. | Proximity mapping of human separase by the BioID approach.
Agircan FG, Hata S, Nussbaum-Krammer C, Atorino E, Schiebel E. | 06/3/2017 |
| The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients. | Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.
Haaß W, Kleiner H, Müller MC, Hofmann WK, Fabarius A, Seifarth W., Free PMC Article | 05/14/2016 |
| Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules. | Sensors at centrosomes reveal determinants of local separase activity.
Agircan FG, Schiebel E., Free PMC Article | 04/30/2016 |
| Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL-positive cell lines under Imatinib treatment. | Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Haaß W, Kleiner H, Weiß C, Haferlach C, Schlegelberger B, Müller MC, Hehlmann R, Hofmann WK, Fabarius A, Seifarth W, Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung, German CML Study Group., Free PMC Article | 04/16/2016 |
| Separase is an oncogene whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies. | Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li XN, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, Sun D, Powell SZ, Ahmed N, Zhang N, Pati D., Free PMC Article | 10/24/2015 |
| High ESPL1 mRNA expression was associated with luminal B breast cancers. | ESPL1 is a candidate oncogene of luminal B breast cancers.
Finetti P, Guille A, Adelaide J, Birnbaum D, Chaffanet M, Bertucci F. | 09/26/2015 |
| Data indicate that separase is subject to native-state cis/trans isomerization by peptidyl-prolyl-isomerase Pin1. | Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.
Hellmuth S, Rata S, Brown A, Heidmann S, Novak B, Stemmann O. | 08/1/2015 |
| Mutation of the homologous position in PTTG1 (H(134)) switched PTTG1 from an inhibitor into an activator of ESP1. | Critical differences between isoforms of securin reveal mechanisms of separase regulation.
Han X, Poon RY., Free PMC Article | 10/26/2013 |
| By consecutively acting as a protease and a cdk1 inhibitor, separase coordinates two key processes to achieve simultaneous and abrupt separation of sister chromatids. | Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Shindo N, Kumada K, Hirota T. | 10/13/2012 |
| Kendrin is a novel and crucial substrate for separase (ESPL1) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. | Kendrin is a novel substrate for separase involved in the licensing of centriole duplication.
Matsuo K, Ohsumi K, Iwabuchi M, Kawamata T, Ono Y, Takahashi M. | 09/29/2012 |
| SMC3 and separase are upregulated and securin is downregulated in malignant transformation of BEAS-2B cells induced by coal tar pitch smoke extracts. | [Change of structural maintenance of chromosome (SMC)1, SMC3, Separase and Securin expression in BEAS-2B malignant transformation cell induced by coal tar pitch smoke extracts].
Li ZT, Wang W, Zhao Y, Wang LX, Zhu HS, Wu WD, Wu YM. | 08/25/2012 |