| USP4 regulates TUT1 ubiquitination status in concert with SART3. | USP4 regulates TUT1 ubiquitination status in concert with SART3.
Kim J, Taketomi T, Yamada A, Uematsu Y, Ueda K, Chiba T, Tsuruta F. | 02/23/2024 |
| Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects. | Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects.
Ayers KL, Eggers S, Rollo BN, Smith KR, Davidson NM, Siddall NA, Zhao L, Bowles J, Weiss K, Zanni G, Burglen L, Ben-Shachar S, Rosensaft J, Raas-Rothschild A, Jørgensen A, Schittenhelm RB, Huang C, Robevska G, van den Bergen J, Casagranda F, Cyza J, Pachernegg S, Wright DK, Bahlo M, Oshlack A, O'Brien TJ, Kwan P, Koopman P, Hime GR, Girard N, Hoffmann C, Shilon Y, Zung A, Bertini E, Milh M, Ben Rhouma B, Belguith N, Bashamboo A, McElreavey K, Banne E, Weintrob N, BenZeev B, Sinclair AH., Free PMC Article | 06/21/2023 |
| Genetic association study detected misalignment in previous whole exome sequence: association study of ZNF806 and SART3 in tardive dystonia. | Genetic association study detected misalignment in previous whole exome sequence: association study of ZNF806 and SART3 in tardive dystonia.
Kanahara N, Nakata Y, Iyo M. | 08/14/2021 |
| rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. | rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer.
Degtyareva AO, Leberfarb EY, Efimova EG, Brusentsov II, Usova AV, Lushnikova EL, Merkulova TI. | 06/5/2021 |
| In vitro binding experiments revealed that the RNA-recognition motifs within the SART3 sequence are responsible for selective pre-miR-34a binding. Our results provide evidence for a significant role of SART3 in miR-34a biogenesis and cell cycle progression in non-small-cell lung cancer (NSCLC) cells. | The RNA-binding protein SART3 promotes miR-34a biogenesis and G(1) cell cycle arrest in lung cancer cells.
Sherman EJ, Mitchell DC, Garner AL., Free PMC Article | 06/13/2020 |
| LASTR promotes splicing efficiency by controlling SART3 association with the U4 and U6 small nuclear ribonucleoproteins (snRNP) during spliceosome recycling. | Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3.
De Troyer L, Zhao P, Pastor T, Baietti MF, Barra J, Vendramin R, Dok R, Lechat B, Najm P, Van Haver D, Impens F, Leucci E, Sablina AA., Free PMC Article | 05/23/2020 |
| Study demonstrated that Tip110 contributed to the regulation of the expression of IL-8 in melanoma cells and that the expression level of Tip110 had a prognostic value for melanoma patients. | Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma.
Timani KA, Győrffy B, Liu Y, Mohammad KS, He JJ., Free PMC Article | 03/23/2019 |
| The findings demonstrate that constitutive Tip110 expression in human cord blood CD34(+) cells is regulated, at least in part, through its interaction with CstF64, recruitment of CstF64 to, and selective usage of two polyadenylation sites within its 3'UTR. | Regulation of Constitutive Tip110 Expression in Human Cord Blood CD34(+) Cells Through Selective Usage of the Proximal and Distal Polyadenylation Sites Within the 3'Untranslated Region.
Liu Y, Huang X, Timani KA, Broxmeyer HE, He JJ. | 02/16/2019 |
| Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43 associate to form complex instrumental in spliceosome assembly; ZIP regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri-snRNP particles are enriched in Cajal body. (ZIP = zinc finger and G-patch domain-containing protein; USP39 = ubiquitin specific peptidase 39; Prp43 = RNA helicase Prp43) | Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.
Chen Z, Gui B, Zhang Y, Xie G, Li W, Liu S, Xu B, Wu C, He L, Yang J, Yi X, Yang X, Sun L, Liang J, Shang Y., Free PMC Article | 11/26/2017 |
| We show that PRP31, a component of U4 snRNP, is modified with K63-linked ubiquitin chains by the PRP19 complex and deubiquitinated by USP15 and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 and this ternary complex serves as a platform to deubiquitinate PRP31 and PRP3 | USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.
Das T, Park JK, Park J, Kim E, Rape M, Kim EE, Song EJ., Free PMC Article | 09/16/2017 |
| The complex structure of SART3 nuclear localization signal (NLS) and importin-alpha reveals bipartite binding, and removal of SART3 NLS prevents the entry of USP4 (and USP15) into the nucleus and abrogates the subsequent deubiquitinase activity of USP4. | Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3.
Park JK, Das T, Song EJ, Kim EE., Free PMC Article | 05/27/2017 |
| crystal structures of SART3 in the apo-form and in complex with the DUSP-UBL domain of USP15 at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 contains 12 half-a-tetratricopeptide (HAT) repeats, organized into two subdomains, HAT-N and HAT-C. SART3 dimerizes through the concave surface of HAT-C, whereas the HAT-C convex surface binds USP15 in a novel bipartite mode. | Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3.
Zhang Q, Harding R, Hou F, Dong A, Walker JR, Bteich J, Tong Y., Free PMC Article | 05/6/2017 |
| miR-124 regulates Tip110 expression and differentiation of human cord blood CD34(+) cells | MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis.
Liu Y, Huang X, Timani KA, Broxmeyer HE, He JJ., Free PMC Article | 06/28/2016 |
| Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome system. Under hypoxia, Tip110 stabilized p53, which in return destabilized Tip110. | Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells.
Timani KA, Liu Y, Fan Y, Mohammad KS, He JJ., Free PMC Article | 08/22/2015 |
| SART3 recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15 | The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.
Long L, Thelen JP, Furgason M, Haj-Yahya M, Brik A, Cheng D, Peng J, Yao T., Free PMC Article | 05/24/2014 |
| these findings have provided additional and mechanistic evidence to support Tip110 function in HIV-1 transcription. | Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription.
Zhao W, Liu Y, Timani KA, He JJ., Free PMC Article | 03/22/2014 |
| Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families | Identification of three novel frameshift mutations of the MVK gene in four Chinese families with disseminated superficial actinic porokeratosis.
Zhou Y, Liu J, Fu X, Yu Y, Shi B, Yu G, Shi Z, Wu W, Pan F, Tian H, Liu H, Zhang F. | 02/1/2014 |
| YB-1 potentiates the Tip110/Tat-mediated transactivation of the HIV-1 LTR promoter. | Tip110 interacts with YB-1 and regulates each other's function.
Timani KA, Liu Y, He JJ., Free PMC Article | 10/19/2013 |
| findings show C-MYC upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 alternative splicing in hESCs | C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.
Liu Y, Timani K, Ou X, Broxmeyer HE, He JJ., Free PMC Article | 08/10/2013 |
| TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. | Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.
Liu Y, Lee MR, Timani K, He JJ, Broxmeyer HE., Free PMC Article | 10/6/2012 |
| Levels of anti-SART3 peptide antibody in prostate cancer patients are significantly higher than those of non-cancer subjects. | Capability of SART3(109-118) peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles.
Mohamed ER, Naito M, Terasaki Y, Niu Y, Gohara S, Komatsu N, Shichijo S, Itoh K, Noguchi M. | 01/21/2010 |
| Both purified and recombinant LSm2-8 proteins are able to recruit p110 protein to U6 snRNA via interaction with the highly conserved C-terminal region of p110. | 3'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins.
Licht K, Medenbach J, Lührmann R, Kambach C, Bindereif A., Free PMC Article | 01/21/2010 |
| involvement of U6-p110 (SART3) in recycling of the U4atac/U6atac snRNP | Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP.
Damianov A, Schreiner S, Bindereif A., Free PMC Article | 01/21/2010 |
| Data suggest a model whereby p110 (SART3) brings together U4 and U6 snRNAs through both RNA-protein and protein-protein interactions. | Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling.
Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A., Free PMC Article | 01/21/2010 |
| detectable in majority of colorectal carcinoma tissues studied; could be an appropriate molecule for use in specific immunotherapy for colorectal carcinoma | Expression of tumor rejection antigens in colorectal carcinomas.
Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K. | 01/21/2010 |