| Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses. | Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses.
Hameed Y. | 03/27/2024 |
| Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner. | Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.
Lee DY, Lee S, Kim YS, Park S, Bae SM, Cho EA, Park EJ, Park HH, Kim SY, So I, Chun JN, Jeon JH., Free PMC Article | 11/7/2023 |
| Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer. | Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
Xie X, Chauhan GB, Edupuganti R, Kogawa T, Park J, Tacam M, Tan AW, Mughees M, Vidhu F, Liu DD, Taliaferro JM, Pitner MK, Browning LS, Lee JH, Shen Y, Wang J, Ueno NT, Krishnamurthy S, Hortobagyi GN, Tripathy D, Van Laere SJ, Bartholomeusz G, Dalby KN, Bartholomeusz C., Free PMC Article | 07/3/2023 |
| ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression. | ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
Liu X, Zhao J, Wu Q, Wang L, Lu W, Feng Y. | 06/23/2023 |
| Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer. | Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.
Szymański Ł, Lieto K, Zdanowski R, Lewicki S, Tassan JP, Kubiak JZ., Free PMC Article | 06/7/2023 |
| Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p. | Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-κB Signaling Axis through MicroRNA-497-5p.
Zhang Y, Lu R, Huang X, Yin E, Yang Y, Yi C, You H, Song X, Yuan X., Free PMC Article | 09/17/2022 |
| LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis. | LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis.
Du J, Xiao J, Zhuo Y, Nie M, Yang J, Luo X, Gu H. | 08/27/2022 |
| Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer. | Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.
Hardeman AA, Han YJ, Grushko TA, Mueller J, Gomez MJ, Zheng Y, Olopade OI., Free PMC Article | 07/2/2022 |
| xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade. | xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade.
Tang B, Zhu J, Liu F, Ding J, Wang Y, Fang S, Zheng L, Qiu R, Chen M, Shu G, Xu M, Lu C, Zhao Z, Yang Y, Ji J., Free PMC Article | 05/14/2022 |
| Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells. | Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells.
Sun H, Ma H, Zhang H, Ji M., Free PMC Article | 02/19/2022 |
| KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway. | KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway.
Shi J, Yang C, An J, Hao D, Liu C, Liu J, Sun J, Jiang J., Free PMC Article | 11/27/2021 |
| MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. | MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma.
Tang Q, Li W, Zheng X, Ren L, Liu J, Li S, Wang J, Du G., Free PMC Article | 10/16/2021 |
| MELK/MPK38 in cancer: from mechanistic aspects to therapeutic strategies. | MELK/MPK38 in cancer: from mechanistic aspects to therapeutic strategies.
Thangaraj K, Ponnusamy L, Natarajan SR, Manoharan R. | 10/9/2021 |
| Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies. | Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.
Jaune E, Cavazza E, Ronco C, Grytsai O, Abbe P, Tekaya N, Zerhouni M, Beranger G, Kaminski L, Bost F, Gesson M, Tulic M, Hofman P, Ballotti R, Passeron T, Botton T, Benhida R, Rocchi S., Free PMC Article | 10/2/2021 |
| High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo. | High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo.
Ikeda Y, Sato S, Yabuno A, Shintani D, Ogasawara A, Miwa M, Zewde M, Miyamoto T, Fujiwara K, Nakamura Y, Hasegawa K., Free PMC Article | 09/4/2021 |
| Suppression of long non-coding RNA PCAT19 inhibits glioma cell proliferation and invasion, and increases cell apoptosis through regulation of MELK targeted by miR-142-5p. | Suppression of long non-coding RNA PCAT19 inhibits glioma cell proliferation and invasion, and increases cell apoptosis through regulation of MELK targeted by miR-142-5p.
Xie YH, Hu J. | 08/28/2021 |
| Ectopic expression of MELK in oral squamous cell carcinoma and its correlation with epithelial mesenchymal transition. | Ectopic expression of MELK in oral squamous cell carcinoma and its correlation with epithelial mesenchymal transition.
Li B, Xu X, Bin X, Zhou J, Tang Z., Free PMC Article | 07/24/2021 |
| BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK. | BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK.
Tian JH, Mu LJ, Wang MY, Zeng J, Long QZ, Guan B, Wang W, Jiang YM, Bai XJ, Du YF. | 05/29/2021 |
| Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma. | Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma.
Jeddo SFA, Wei X, Li K, Li X, Yang Q, Dongol S, Li J., Free PMC Article | 05/22/2021 |
| MELK Accelerates the Progression of Colorectal Cancer via Activating the FAK/Src Pathway. | MELK Accelerates the Progression of Colorectal Cancer via Activating the FAK/Src Pathway.
Liu G, Zhan W, Guo W, Hu F, Qin J, Li R, Liao X. | 02/6/2021 |
| MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway. | MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway.
Xu Q, Ge Q, Zhou Y, Yang B, Yang Q, Jiang S, Jiang R, Ai Z, Zhang Z, Teng Y., Free PMC Article | 10/3/2020 |
| MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40. | MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40.
Zhang H, Wei P, Lv W, Han X, Yang J, Qin S, Zhang Y., Free PMC Article | 09/19/2020 |
| MELK is a poor biomarker for non-small-cell lung carcinoma patients | Higher maternal embryonic leucine zipper kinase mRNA expression level is a poor prognostic factor in non-small-cell lung carcinoma patients.
Zang X, Qian C, Ruan Y, Xie J, Luo T, Xu B, Jiang J. | 07/4/2020 |
| We analyzed the expression of MELK and two putative targets, Forkhead Box M1 (FOXM1) and Enhancer of Zeste Homolog 2 (EZH2), in a collection of human iCCA by real-time RT-PCR and immunohistochemistry (IHC). The effects on iCCA growth of both the multi-kinase inhibitor OTSSP167 and specific small-interfering RNA (siRNA) against MELK were investigated in iCCA cell lines. | Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma.
Cigliano A, Pilo MG, Mela M, Ribback S, Dombrowski F, Pes GM, Cossu A, Evert M, Calvisi DF, Utpatel K., Free PMC Article | 06/13/2020 |
| These findings uncover an important role of MELK and USP36 in mediating EZH2 stability in extranodal natural killer/T-cell lymphoma (NKTL). Moreover, MELK overexpression led to decreased sensitivity to bortezomib treatment in NKTL based on deprivation of EZH2 ubiquitination. | MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma.
Li B, Yan J, Phyu T, Fan S, Chung TH, Mustafa N, Lin B, Wang L, Eichhorn PJA, Goh BC, Ng SB, Kappei D, Chng WJ. | 03/21/2020 |