| Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1. | Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1.
Ren X, Shen L, Gao S. | 10/24/2023 |
| A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1. | A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.
Ge R, Wang C, Liu J, Jiang H, Jiang X, Liu Z. | 03/6/2023 |
| Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma. | Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.
Zhang K, Zhou J, Wu T, Tian Q, Liu T, Wang W, Zhong H, Chen Z, Xiao X, Wu G., Free PMC Article | 08/27/2022 |
| MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation. | MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation.
Li M, Shi M, Hu C, Chen B, Li S. | 01/15/2022 |
| Up-regulation of GINS1 highlighted a good diagnostic and prognostic potential of survival in three different subtypes of human cancer. | Up-regulation of GINS1 highlighted a good diagnostic and prognostic potential of survival in three different subtypes of human cancer.
Ahmad M, Hameed Y, Khan M, Usman M, Rehman A, Abid U, Asif R, Ahmed H, Hussain MS, Rehman JU, Asif HM, Arshad R, Atif M, Hadi A, Sarfraz U, Khurshid U. | 12/18/2021 |
| mRNA expressions of all GINS subunits were significantly up-regulated in hepatocellular carcinoma tumor than in non-tumor liver tissues. | Up-regulated and interrelated expressions of GINS subunits predict poor prognosis in hepatocellular carcinoma.
Lian YF, Li SS, Huang YL, Wei H, Chen DM, Wang JL, Huang YH., Free PMC Article | 08/3/2019 |
| High GINS1 expression is associated with reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in glioblastoma. | Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma.
Kimura T, Cui D, Kawano H, Yoshitomi-Sakamoto C, Takakura N, Ikeda E., Free PMC Article | 03/2/2019 |
| The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. | New insights into the GINS complex explain the controversy between existing structural models.
Carroni M, De March M, Medagli B, Krastanova I, Taylor IA, Amenitsch H, Araki H, Pisani FM, Patwardhan A, Onesti S., Free PMC Article | 10/20/2018 |
| Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. | Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E., Free PMC Article | 09/16/2017 |
| PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. | [Expression and clinical significance of GINS complex in colorectal cancer].
Wei HB, Wen JZ, Wei B, Han XY, Zhang S. | 05/11/2013 |
| These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. | Up-regulation of PSF1 promotes the growth of breast cancer cells.
Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T. | 02/26/2011 |
| Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. | PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.
Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N. | 03/15/2010 |
| expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 | A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.
Hayashi R, Arauchi T, Tategu M, Goto Y, Yoshida K., Free PMC Article | 01/21/2010 |
| the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity | Structure of the human GINS complex and its assembly and functional interface in replication initiation.
Kamada K, Kubota Y, Arata T, Shindo Y, Hanaoka F. | 01/21/2010 |