| MicroRNA-152 specifically targets kinesin family member 14 to suppress the advancement of bladder cancer cells via PI3K/AKT pathway. | MicroRNA-152 specifically targets kinesin family member 14 to suppress the advancement of bladder cancer cells via PI3K/AKT pathway.
Meng F, Zhang Z. | 01/11/2024 |
| KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-kappaB pathway in cholangiocarcinoma. | KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma.
Jiang W, Wang J, Yang X, Shan J, Zhang Y, Shi X, Wang Y, Chenyan A, Chang J, Wang Y, Yu Y, Li C, Li X. | 04/27/2023 |
| KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation. | KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation.
Liu L, Li M, Zhang J, Xu D, Guo Y, Zhang H, Cang S. | 03/15/2023 |
| Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer. | Single Nucleotide Variants in KIF14 Gene May Have Prognostic Value in Breast Cancer.
Krus I, Brynychová V, Hlaváč V, Václavíková R, Kováčová M, Koževnikovová R, Kopečková K, Tornikidis J, Vrána D, Gatěk J, Souček P. | 11/5/2022 |
| Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma. | Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma.
Wang H, Tang F, Tang P, Zhang L, Gan Q, Li Y., Free PMC Article | 10/29/2022 |
| KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27(Kip1) pathway. | KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27(Kip1) pathway.
Zhang J, Buranjiang G, Mutalifu Z, Jin H, Yao L., Free PMC Article | 04/30/2022 |
| Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14. | Exosomes-derived miR-154-5p attenuates esophageal squamous cell carcinoma progression and angiogenesis by targeting kinesin family member 14.
Shou Y, Wang X, Liang Y, Liu X, Chen K., Free PMC Article | 03/26/2022 |
| LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14). | LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).
Zhao Q, Chen S, Chen L., Free PMC Article | 02/26/2022 |
| miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14. | miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14.
Xu HK, Wang XD, Wang DG, Wei DD, Liang L, Liu CH. | 12/4/2021 |
| Prognostic Impact and Functional Annotations of KIF11 and KIF14 Expression in Patients with Colorectal Cancer. | Prognostic Impact and Functional Annotations of KIF11 and KIF14 Expression in Patients with Colorectal Cancer.
Neska-Długosz I, Buchholz K, Durślewicz J, Gagat M, Grzanka D, Tojek K, Klimaszewska-Wiśniewska A., Free PMC Article | 10/30/2021 |
| Dysregulation of KIF14 regulates the cell cycle and predicts poor prognosis in cervical cancer: a study based on integrated approaches. | Dysregulation of KIF14 regulates the cell cycle and predicts poor prognosis in cervical cancer: a study based on integrated approaches.
Xiao L, Zhang S, Zheng Q, Zhang S., Free PMC Article | 09/18/2021 |
| KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. | KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling.
Pejskova P, Reilly ML, Bino L, Bernatik O, Dolanska L, Ganji RS, Zdrahal Z, Benmerah A, Cajanek L., Free PMC Article | 03/20/2021 |
| Study confirms a high expression level of KIF14 in glioma tissues and cells. Its expression is regulated by LncRNA PAXIP1-AS1 which could upregulate its promoter activity by recruiting transcription factor ETS1. | Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression.
Xu H, Zhao G, Zhang Y, Jiang H, Wang W, Zhao D, Yu H, Qi L., Free PMC Article | 05/9/2020 |
| our results demonstrate that KIF14 mutations result in a severe syndrome associating microcephaly and RHD through its conserved function in cytokinesis during kidney and brain development. | Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Gregory-Evans CY, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah A., Free PMC Article | 03/14/2020 |
| SNP rs10800708 within the KIF14 miRNA binding site is linked with breast cancer. | SNP rs10800708 within the KIF14 miRNA binding site is linked with breast cancer.
Shasttiri A, Rostamian Delavar M, Baghi M, Dehghani Ashkezari M, Ghaedi K. | 12/21/2019 |
| that KIF14 is overexpressed in gastric cancer, is correlated with poor prognosis and plays a crucial role in the progression and metastasis of gastric cancer. | KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
Yang Z, Li C, Yan C, Li J, Yan M, Liu B, Zhu Z, Wu Y, Gu Q. | 08/17/2019 |
| KIF14 missense and loss of function variants were identified in intellectual disability with microcephaly patients. | Biallelic variants in KIF14 cause intellectual disability with microcephaly.
Makrythanasis P, Maroofian R, Stray-Pedersen A, Musaev D, Zaki MS, Mahmoud IG, Selim L, Elbadawy A, Jhangiani SN, Coban Akdemir ZH, Gambin T, Sorte HS, Heiberg A, McEvoy-Venneri J, James KN, Stanley V, Belandres D, Guipponi M, Santoni FA, Ahangari N, Tara F, Doosti M, Iwaszkiewicz J, Zoete V, Backe PH, Hamamy H, Gleeson JG, Lupski JR, Karimiani EG, Antonarakis SE., Free PMC Article | 12/22/2018 |
| KIF14 is upregulated in PCa cell lines and clinical PCa tissues. Inhibition of KIF14 suppresses cell proliferation, induces G2 arrest and apoptosis. | Overexpression of a novel candidate oncogene KIF14 correlates with tumor progression and poor prognosis in prostate cancer.
Zhang Y, Yuan Y, Liang P, Zhang Z, Guo X, Xia L, Zhao Y, Shu XS, Sun S, Ying Y, Cheng Y., Free PMC Article | 04/14/2018 |
| In particular, counteracting forces between minus-end-directed kinesin-14 and plus-end-directed kinesin-5 motors have recently been implicated in the regulation of microtubule nucleation. | Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation.
She ZY, Yang WX. | 03/31/2018 |
| The mechanochemical cycle of kinesin-14 has been reported. | Working stroke of the kinesin-14, ncd, comprises two substeps of different direction.
Nitzsche B, Dudek E, Hajdo L, Kasprzak AA, Vilfan A, Diez S., Free PMC Article | 02/3/2018 |
| Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. | Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas.
Liang ML, Hsieh TH, Ng KH, Tsai YN, Tsai CF, Chao ME, Liu DJ, Chu SS, Chen W, Liu YR, Liu RS, Lin SC, Ho DM, Wong TT, Yang MH, Wang HW., Free PMC Article | 12/2/2017 |
| This study identified the mutations in KIF14 as a new cause of primary microcephaly and using cellular experiments demonstrate that impaired cytokinesis, increased apoptosis, and reduced cell motility are features of the associated pathogenesis. | Mutations of KIF14 cause primary microcephaly by impairing cytokinesis.
Moawia A, Shaheen R, Rasool S, Waseem SS, Ewida N, Budde B, Kawalia A, Motameny S, Khan K, Fatima A, Jameel M, Ullah F, Akram T, Ali Z, Abdullah U, Irshad S, Höhne W, Noegel AA, Al-Owain M, Hörtnagel K, Stöbe P, Baig SM, Nürnberg P, Alkuraya FS, Hahn A, Hussain MS. | 11/4/2017 |
| Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. | A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA., Free PMC Article | 09/30/2017 |
| Studied overexpression of KIF14 which showed the tight correlation between KIF14 upregulation and inferior clinical outcome in medulloblastoma (MB), suggesting KIF14 is a potential negative prognostic marker in MB. Transient, siRNAs-mediated downregulation of KIF14 suppressed cell proliferation and induced apoptosis in two MB cell lines. | The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
Li KK, Qi Y, Xia T, Chan AK, Zhang ZY, Aibaidula A, Zhang R, Zhou L, Yao Y, Ng HK. | 09/2/2017 |
| study suggests that KIF14 may serve as a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer. | Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
Wang W, Shi Y, Li J, Cui W, Yang B., Free PMC Article | 12/17/2016 |