| Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation. | Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
Shizu R, Makida N, Sobe K, Ishimura M, Takeshita A, Hosaka T, Kanno Y, Sasaki T, Yoshinari K. | 03/1/2024 |
| Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. | Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Yoshinari K, Shizu R. | 07/16/2022 |
| Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. | Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling.
Li Z, Kwon SM, Li D, Li L, Peng X, Zhang J, Sueyoshi T, Raufman JP, Negishi M, Wang XW, Wang H., Free PMC Article | 06/11/2022 |
| Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. | Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T., Free PMC Article | 05/7/2022 |
| Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. | Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
de Almeida Velozo C, de Almeida TB, de Azevedo MCVM, Espasandin I, da Cunha Pinto JF, López S, Pizzatti L, Tanuri A, da Silva Santos S, Ribeiro-Alves M, Cardoso CC. | 03/12/2022 |
| Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. | Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.
Lai B, Xie X, Li F, Cui Q, Dang E, Luo W, Wang N, Zheng Y, Wang G, Xiao L, Wang N. | 12/11/2021 |
| Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium. | Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium.
López-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L., Free PMC Article | 10/30/2021 |
| Role of the constitutive androstane receptor (CAR) in human liver cancer. | Role of the constitutive androstane receptor (CAR) in human liver cancer.
Bae SDW, Nguyen R, Qiao L, George J. | 07/24/2021 |
| Regulation of CAR and PXR Expression in Health and Disease. | Regulation of CAR and PXR Expression in Health and Disease.
Daujat-Chavanieu M, Gerbal-Chaloin S., Free PMC Article | 06/19/2021 |
| Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. | Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p.
Deng Y, Wei Z, Huang M, Xu G, Wei W, Peng B, Nong S, Qin H., Free PMC Article | 04/24/2021 |
| Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR. | Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR.
Küblbeck J, Niskanen J, Honkakoski P., Free PMC Article | 04/13/2021 |
| Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients. | Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients.
Kong FC, Ma CL, Lang LQ, Zhong MK. | 01/23/2021 |
| Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity. | Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity.
Wang Y, Xiang X, Huang WW, Sandford AJ, Wu SQ, Zhang MM, Wang MG, Chen G, He JQ., Free PMC Article | 10/24/2020 |
| the GSK3-mediated regulation of CAR dynamics through the involvement of Akt pathway, is reported. | Influence of signaling kinases on functional dynamics of nuclear receptor CAR.
Yende AS, Tyagi RK. | 01/11/2020 |
| adenosine deaminase acting on RNA 1 (ADAR1) and ADAR2, which catalyze adenosine-to-inosine RNA editing, downregulate the expression of constitutive androstane receptor (CAR) in human liver-derived cells by attenuating splicing | Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing.
Nakano M, Fukami T, Nakajima M. | 01/4/2020 |
| he ChIP-exo analyses also identified distinct binding motifs for the respective mouse and human receptors. Together, the results provide new insights into the important roles that CAR contributes as a key modulator of numerous signaling pathways in mammalian organisms, presenting a genomic context that specifies species variation in biological processes under CAR's control, including liver cell proliferation | In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.
Niu B, Coslo DM, Bataille AR, Albert I, Pugh BF, Omiecinski CJ., Free PMC Article | 06/29/2019 |
| specific association of NR1I3, C6 and TNN with low hip BMD risk | Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk.
Han YY, Zhao LJ, Lin Y, He H, Tian Q, Zhu W, Shen H, Chen XD, Deng HW., Free PMC Article | 02/16/2019 |
| Expression of microRNA potentially regulated by AhR and CAR in malignant tumors of the endometrium has been reported. | Expression of microRNA Potentially Regulated by AhR and CAR in Malignant Tumors of the Endometrium.
Ushakov DS, Dorozhkova AS, Babayants EV, Ovchinnikov VY, Kushlinskii DN, Adamyan LV, Gulyaeva LF, Kushlinskii NE. | 12/29/2018 |
| Phosphomimetic substitution of Thr-38 with Asp increased co-immunoprecipitation of the CAR DNA Binding Domain with CAR Ligand Binding Domain in Huh-7 cells. The underlying molecular mechanism that regulates CAR activation is its homodimer-monomer-heterodimer conversion; the monomer and homodimer are phosphorylated at Thr-38 and inactive. | Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation.
Shizu R, Min J, Sobhany M, Pedersen LC, Mutoh S, Negishi M., Free PMC Article | 12/1/2018 |
| Results suggest that TRIM24 is a novel coactivator of the CAR that is involved in cell- and/or promoter- selective transactivation. | Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor.
Kanno Y, Kure Y, Kobayashi S, Mizuno M, Tsuchiya Y, Yamashita N, Nemoto K, Inouye Y. | 08/4/2018 |
| An overview of NR1I2 and NR1I3 pharmacogenetic studies in various therapeutic fields. | Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.
Mbatchi LC, Brouillet JP, Evrard A. | 07/28/2018 |
| replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation | Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients.
Kurzawski M, Malinowski D, Dziewanowski K, Droździk M. | 03/10/2018 |
| Dual ligands of CAR/PXR show distinct gene regulation patterns by regulating cross-talk between CAR and PXR. | Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
Kanno Y, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y. | 01/27/2018 |
| Data suggest both PXR and CAR are expressed in testis/Sertoli cells; exposure of Sertoli cells (in vitro model of blood-testis barrier) to PXR or CAR ligands (including antiretroviral drugs) up-regulates expression of Pgp/ABCB1, BCRP, and MRP4. (PXR = pregnane X receptor; CAR = constitutive androstane receptor; Pgp/ABCB1 = P-glycoprotein ABCB1; BCRP = breast cancer resistance protein; MRP4 =multidrug resistance protein 4) | Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
Whyte-Allman SK, Hoque MT, Jenabian MA, Routy JP, Bendayan R. | 11/26/2017 |
| Genome-wide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARalpha in primary human hepatocytes has been presented. | Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM. | 06/3/2017 |