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    CDC42 cell division cycle 42 [ Homo sapiens (human) ]

    Gene ID: 998, updated on 9-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway.

    Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway.
    Zheng S, Zhao N, Feng C, Ma J.

    05/31/2024
    The ability and optimal cutoff value of serum cell division cycle 42 in estimating major adverse cardiac event in STEMI patients treated with percutaneous coronary intervention.

    The ability and optimal cutoff value of serum cell division cycle 42 in estimating major adverse cardiac event in STEMI patients treated with percutaneous coronary intervention.
    Luan S, Zhang L, Cheng X, Wang Y, Feng Q, Wei L, Jiang F, Liu J.

    03/13/2024
    MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.

    MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
    Cerdido S, Abrisqueta M, Sánchez-Beltrán J, Lambertos A, Castejón-Griñán M, Muñoz C, Olivares C, García-Borrón JC, Jiménez-Cervantes C, Herraiz C.

    12/21/2023
    ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.

    ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
    Jin JC, Chen BY, Deng CH, Chen JN, Xu F, Tao Y, Hu CL, Xu CH, Chang BH, Wang Y, Fei MY, Liu P, Yu PC, Li ZJ, Li XY, Chen SB, Jiang YL, Chen XC, Zong LJ, Zhang JY, Ren YY, Xu FH, Liu Q, Huang XH, Guo J, He Q, Song LX, Zhou LY, Su JY, Xiao C, Zhang YM, Yan M, Zhang Z, Wu D, Chang CK, Li X, Wang L, Wu LY.

    12/4/2023
    Cell Division Control Protein 42 Facilitates Diabetic Retinopathy Progression by Activating the MEK/ERK Pathway.

    Cell Division Control Protein 42 Facilitates Diabetic Retinopathy Progression by Activating the MEK/ERK Pathway.
    Cao H, Hou C.

    11/28/2023
    A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.

    A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
    Assing K, Jørgensen SE, Sandgaard KS, De Keukeleere K, B-Hansen M, Petersen MS, Hartling UB, Vaal TMK, Nielsen C, Jakobsen MA, Watt E, Adams S, Hao Q, Fagerberg C, Mogensen TH., Free PMC Article

    11/22/2023
    C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib.

    C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib.
    Kapp FG, Kretschmer S, Beckmann CCA, Wäsch L, Molitor A, Carapito R, Schubert M, Lucas N, Conrad S, Poignant S, Isidor B, Rohlfs M, Kisaarslan AP, Schanze D, Zenker M, Schmitt-Graeff A, Strahm B, Peters A, Yoshimi A, Driever W, Zillinger T, Günther C, Maharana S, Guan K, Klein C, Ehl S, Niemeyer CM, Unal E, Bahram S, Hauck F, Lee-Kirsch MA, Speckmann C.

    11/8/2023
    Serum cell division cycle 42 in advanced hepatocellular carcinoma patients: Linkage with clinical characteristics and immune checkpoint inhibitor-related treatment outcomes.

    Serum cell division cycle 42 in advanced hepatocellular carcinoma patients: Linkage with clinical characteristics and immune checkpoint inhibitor-related treatment outcomes.
    Xu J, Shao R, Zhang X, Yao D, Han S.

    11/3/2023
    Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.

    Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
    Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K.

    08/27/2023
    Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3beta-beta-catenin cascade via regulation of Rac1/Cdc42.

    Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
    Wang X, Zhang X, Sun J, Sun Y, Zhang Y, He L, Wang P, Li F, Sun C.

    08/10/2023
    Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling.

    Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling.
    Hladyshau S, Stoop JP, Kamada K, Nie S, Tsygankov D., Free PMC Article

    07/5/2023
    Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.

    Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation.
    Adhicary S, Fanelli K, Nakisli S, Ward B, Pearce I, Nielsen CM., Free PMC Article

    05/28/2023
    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.
    Bogucka-Janczi K, Harms G, Coissieux MM, Bentires-Alj M, Thiede B, Rajalingam K., Free PMC Article

    05/19/2023
    "From molecular to clinic": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib.

    "From molecular to clinic": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib.
    Wei E, Li J, Anand P, French LE, Wattad A, Clanner-Engelshofen B, Reinholz M., Free PMC Article

    03/27/2023
    Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes.

    Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes.
    Yuen WS, Zhang QH, Bourdais A, Adhikari D, Halet G, Carroll J., Free PMC Article

    03/10/2023
    The clinical role of serum cell division control 42 in coronary heart disease.

    The clinical role of serum cell division control 42 in coronary heart disease.
    Feng Q, Guo J, Hou A, Guo Z, Zhang Y, Guo Y, Liu S, Cheng Z, Sun L, Meng L, Han S.

    02/14/2023
    AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.

    AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.
    Sun B, Ding B, Chen Y, Peng C, Chen X., Free PMC Article

    02/14/2023
    Role of a small GTPase Cdc42 in aging and age-related diseases.

    Role of a small GTPase Cdc42 in aging and age-related diseases.
    Umbayev B, Safarova Yantsen Y, Yermekova A, Nessipbekova A, Syzdykova A, Askarova S.

    01/21/2023
    ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.

    ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
    Kreider-Letterman G, Castillo A, Mahlandt EK, Goedhart J, Rabino A, Goicoechea S, Garcia-Mata R., Free PMC Article

    12/31/2022
    Cell division cycle 42 positively correlates with T helper 2 cytokine, effusion viscosity, and hearing loss degree in otitis media with effusion patients.

    Cell division cycle 42 positively correlates with T helper 2 cytokine, effusion viscosity, and hearing loss degree in otitis media with effusion patients.
    Wu D, Yang Y, Duan C., Free PMC Article

    12/3/2022
    CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.

    CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
    Li G, Wang Y, Guo XB, Zhao B.

    11/5/2022
    Cell division cycle 42 reflects disease risk, symptoms, Th1/Th2 disproportion, and its short-term variation indicates symptom amelioration after treatment in allergic rhinitis patients.

    Cell division cycle 42 reflects disease risk, symptoms, Th1/Th2 disproportion, and its short-term variation indicates symptom amelioration after treatment in allergic rhinitis patients.
    Zhang X, Xie L, Fang X., Free PMC Article

    10/15/2022
    The relation of circulating cell division cycle 42 expression with Th1, Th2, and Th17 cells, adhesion molecules, and biochemical indexes in coronary heart disease patients.

    The relation of circulating cell division cycle 42 expression with Th1, Th2, and Th17 cells, adhesion molecules, and biochemical indexes in coronary heart disease patients.
    Zhou M, Wu J, Tan G.

    10/1/2022
    MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/beta-catenin signaling pathway.

    MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway.
    Wang Q, Qi C, Min P, Wang Y, Ye F, Xia T, Zhang Y, Du J., Free PMC Article

    09/24/2022
    CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport.

    CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport.
    Jiang R, Tang X, Pan J, Li G, Yang N, Tang Y, Bi S, Cai H, Chen Q, Chen D, Wang H, Kong S., Free PMC Article

    09/24/2022
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