| Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3.
Garcia-Pardo J, Bartolomé-Nafría A, Chaves-Sanjuan A, Gil-Garcia M, Visentin C, Bolognesi M, Ricagno S, Ventura S., Free PMC Article | 01/21/2023 |
| HNRPDL transforms hematopoietic cells and a novel HNRPDL/PBX1 axis plays an important role in human CML CD34(+) cells | Oncogenic heterogeneous nuclear ribonucleoprotein D-like modulates the growth and imatinib response of human chronic myeloid leukemia CD34(+) cells via pre-B-cell leukemia homeobox 1.
Ji D, Zhang P, Ma W, Fei Y, Xue W, Wang Y, Zhang X, Zhou H, Zhao Y. | 04/18/2020 |
| High HNRNPDL expression is associated with cervical cancer. | hnRNPDL extensively regulates transcription and alternative splicing.
Li RZ, Hou J, Wei Y, Luo X, Ye Y, Zhang Y. | 01/19/2019 |
| Heterogeneous nuclear ribonucleoprotein D-like (HNRPDL) is aberrantly expressed in specimens from colorectal cancer patients. | Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle.
Zhang P, Ji D, Hu X, Ni H, Ma W, Zhang X, Liao S, Zeng Z, Zhao Y, Zhou H. | 12/22/2018 |
| Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. | Auto- and cross-regulation of the hnRNPs D and DL.
Kemmerer K, Fischer S, Weigand JE., Free PMC Article | 07/7/2018 |
| A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G. | A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G).
Vieira NM, Naslavsky MS, Licinio L, Kok F, Schlesinger D, Vainzof M, Sanchez N, Kitajima JP, Gal L, Cavaçana N, Serafini PR, Chuartzman S, Vasquez C, Mimbacas A, Nigro V, Pavanello RC, Schuldiner M, Kunkel LM, Zatz M. | 02/21/2015 |
| hnRNP DL and CNBP are novel antigens for SLE patients | Proteomic analyses and identification of arginine methylated proteins differentially recognized by autosera from anti-Sm positive SLE patients.
Chang HH, Hu HH, Lee YJ, Wei HM, Fan-June MC, Hsu TC, Tsay GJ, Li C., Free PMC Article | 02/15/2014 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs. | JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.
Omnus DJ, Mehrtens S, Ritter B, Resch K, Yamada M, Frank R, Nourbakhsh M, Reboll MR. | 05/14/2011 |
| Study shows that there is interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2, indicating that JKTBP2 may have an important function in AD formation. | [The interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2].
Wang WW, Li ZD, Liu RZ, Hong SG, Xu XX, Chen YG. | 06/14/2010 |
| overexpression of JKTBP1 in LNCaP cells leads to abnormal cell proliferation | Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R).
Wu YY, Li H, Lv XY, Wei Q, Li X, Liu XY, Zhou Q, Wei YQ. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.
Walker LC, Waddell N, Ten Haaf A, kConFab Investigators, Grimmond S, Spurdle AB. | 03/13/2008 |
| The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity. | NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.
Reboll MR, Oumard A, Gazdag AC, Renger I, Ritter B, Schwarzer M, Hauser H, Wood M, Yamada M, Resch K, Nourbakhsh M., Free PMC Article | 01/21/2010 |