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    TSC22D3 TSC22 domain family member 3 [ Homo sapiens (human) ]

    Gene ID: 1831, updated on 17-Oct-2021

    Summary

    Official Symbol
    TSC22D3provided by HGNC
    Official Full Name
    TSC22 domain family member 3provided by HGNC
    Primary source
    HGNC:HGNC:3051
    See related
    Ensembl:ENSG00000157514 MIM:300506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIP; GILZ; DSIPI; TSC-22R
    Summary
    This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in fat (RPKM 114.8), appendix (RPKM 102.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSC22D3 in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (107713221..107777329, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106956451..107019218, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 3 Neighboring gene FRMPD3 antisense RNA 1 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene nuclear cap binding protein subunit 2 like Neighboring gene midline 2 Neighboring gene uncharacterized LOC101928335

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp313A1123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TSC22 domain family protein 3
    Names
    DSIP-immunoreactive leucine zipper protein
    DSIP-immunoreactive peptide
    TSC-22 related protein
    TSC-22-like protein
    delta sleep-inducing peptide immunoreactor
    glucocorticoid-induced leucine zipper protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015881.2NP_001015881.1  TSC22 domain family protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001015881.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AB025432, AL590423, BQ919216, CR933650
      Consensus CDS
      CCDS35365.1
      UniProtKB/Swiss-Prot
      Q99576
      UniProtKB/TrEMBL
      Q5JRJ2
      Related
      ENSP00000361466.4, ENST00000372390.8
      Conserved Domains (1) summary
      pfam01166
      Location:157
      TSC22; TSC-22/dip/bun family
    2. NM_001318468.1NP_001305397.1  TSC22 domain family protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      BX647854, CR933650, DA170687
      Consensus CDS
      CCDS14530.1
      UniProtKB/Swiss-Prot
      Q99576
      Related
      ENSP00000314655.4, ENST00000315660.8
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    3. NM_001318470.1NP_001305399.1  TSC22 domain family protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AK092645, CR933650, DA170687
      Consensus CDS
      CCDS14530.1
      UniProtKB/Swiss-Prot
      Q99576
      Related
      ENSP00000361459.2, ENST00000372384.6
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    4. NM_004089.4NP_004080.2  TSC22 domain family protein 3 isoform 2

      See identical proteins and their annotated locations for NP_004080.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 5' end exon compared to transcript variant 1, resulting in an isoform (2) with a different and a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AB025432, AL110191, AL590423, CR933650
      Consensus CDS
      CCDS14531.1
      UniProtKB/Swiss-Prot
      Q99576
      Related
      ENSP00000361474.2, ENST00000372397.6
      Conserved Domains (1) summary
      cd21940
      Location:57134
      ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
    5. NM_198057.3NP_932174.1  TSC22 domain family protein 3 isoform 1

      See identical proteins and their annotated locations for NP_932174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AK092669, BM047061, CR933650
      Consensus CDS
      CCDS14530.1
      UniProtKB/Swiss-Prot
      Q99576
      Related
      ENSP00000361458.4, ENST00000372383.9
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      107713221..107777329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262099.1XP_005262156.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005262156.1

      UniProtKB/Swiss-Prot
      Q99576
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    2. XM_011530884.1XP_011529186.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011529186.1

      UniProtKB/Swiss-Prot
      Q99576
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    3. XM_005262103.4XP_005262160.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005262160.1

      UniProtKB/Swiss-Prot
      Q99576
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    4. XM_005262102.1XP_005262159.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005262159.1

      UniProtKB/Swiss-Prot
      Q99576
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    5. XM_005262100.1XP_005262157.1  TSC22 domain family protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005262157.1

      UniProtKB/Swiss-Prot
      Q99576
      Related
      ENSP00000427427.1, ENST00000506081.5
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
    6. XM_017029335.1XP_016884824.1  TSC22 domain family protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q99576
      Conserved Domains (1) summary
      pfam01166
      Location:124180
      TSC22; TSC-22/dip/bun family
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