NCOR1 nuclear receptor corepressor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCOR1provided by HGNC
Official Full Name: nuclear receptor corepressor 1provided by HGNC
Primary source: HGNC:HGNC:7672
See related: Ensembl:ENSG00000141027 MIM:600849; AllianceGenome:HGNC:7672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
Summary: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Expression: Ubiquitous expression in thyroid (RPKM 10.9), colon (RPKM 10.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p12-p11.2

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (16029157..16215534, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (15931369..16117845, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (15932471..16118848, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCoR1 limits angiogenic capacity by altering Notch signaling.
Title: NCoR1 limits angiogenic capacity by altering Notch signaling.
Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.
Title: Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.
Pulling rank with RNA: RANKL promotes the association of PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.
Title: Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.
NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis.
Title: NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis.
NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation.
Title: NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation.
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer.
Title: Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer.
Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
Title: Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer.
Title: Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer.
NCOR1 may be a potential biomarker of a novel molecular subtype of prostate cancer.
Title: NCOR1 may be a potential biomarker of a novel molecular subtype of prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (102)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif is identified to have a physical interaction with nuclear receptor corepressor 1 (NCOR1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-150171 (e-PCR)
- UniSTS:183054

SHGC-81346 (e-PCR)
- UniSTS:102706

RH47121 (e-PCR)
- UniSTS:51508

SHGC-31118 (e-PCR)
- UniSTS:83280

D17S1843 (e-PCR), detects polymorphism
- UniSTS:6482

RH91243 (e-PCR)
- UniSTS:85172

D17S1410E (e-PCR)
- UniSTS:150455

D17S1674 (e-PCR)
- UniSTS:65990

RH18301 (e-PCR)
- UniSTS:3015

RH81063 (e-PCR)
- UniSTS:92887

RH102915 (e-PCR)
- UniSTS:97249

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
part_of histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor corepressor 1

Names: protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047111.1 RefSeqGene

Range

6213..192590

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001190438.1 → NP_001177367.1 nuclear receptor corepressor 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AF303586, BC056862

Consensus CDS

CCDS54094.1

UniProtKB/Swiss-Prot

O75376

UniProtKB/TrEMBL

Q6PGR4

Related

ENSP00000379189.1, ENST00000395848.5

Conserved Domains (4) summary

pfam05887
Location:596 → 677

Trypan_PARP; Procyclic acidic repetitive protein (PARP)

smart00717
Location:518 → 563

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:518 → 561

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:41 → 128

GPS2_interact; G-protein pathway suppressor 2-interacting domain
NM_001190440.1 → NP_001177369.1 nuclear receptor corepressor 1 isoform 3

See identical proteins and their annotated locations for NP_001177369.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AB028970, AC002553, AW015698, BC056862

Consensus CDS

CCDS54095.1

UniProtKB/TrEMBL

Q7Z516

Related

ENSP00000379192.1, ENST00000395851.5

Conserved Domains (4) summary

cd00167
Location:440 → 482

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:723 → 919

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
NM_006311.4 → NP_006302.2 nuclear receptor corepressor 1 isoform 1

See identical proteins and their annotated locations for NP_006302.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC002553, AF044209, AW015698, BJ995810

Consensus CDS

CCDS11175.1

UniProtKB/Swiss-Prot

B3DLF8, E9PGV6, O75376, Q86YY0, Q9UPV5, Q9UQ18

UniProtKB/TrEMBL

Q7Z516

Related

ENSP00000268712.2, ENST00000268712.8

Conserved Domains (4) summary

cd00167
Location:440 → 482

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:704 → 914

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

16029157..16215534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524086.4 → XP_011522388.1 nuclear receptor corepressor 1 isoform X36

See identical proteins and their annotated locations for XP_011522388.1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:440 → 482

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:723 → 919

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_006721604.5 → XP_006721667.1 nuclear receptor corepressor 1 isoform X16

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:440 → 482

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:627 → 670

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:723 → 919

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_005256872.6 → XP_005256929.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459, Q7Z516

Related

ENSP00000389839.2, ENST00000436068.2

Conserved Domains (3) summary

cd00167
Location:627 → 670

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:683 → 857

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_047437141.1 → XP_047293097.1 nuclear receptor corepressor 1 isoform X33
XM_047437133.1 → XP_047293089.1 nuclear receptor corepressor 1 isoform X23
XM_047437128.1 → XP_047293084.1 nuclear receptor corepressor 1 isoform X15
XM_047437122.1 → XP_047293078.1 nuclear receptor corepressor 1 isoform X5
XM_005256871.6 → XP_005256928.1 nuclear receptor corepressor 1 isoform X4

UniProtKB/TrEMBL

Q7Z516

Related

ENST00000704743.1

Conserved Domains (3) summary

cd00167
Location:628 → 671

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:684 → 858

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_047437140.1 → XP_047293096.1 nuclear receptor corepressor 1 isoform X32
XM_047437134.1 → XP_047293090.1 nuclear receptor corepressor 1 isoform X24
XM_047437132.1 → XP_047293088.1 nuclear receptor corepressor 1 isoform X21
XM_047437125.1 → XP_047293081.1 nuclear receptor corepressor 1 isoform X10
XM_047437144.1 → XP_047293100.1 nuclear receptor corepressor 1 isoform X39
XM_047437138.1 → XP_047293094.1 nuclear receptor corepressor 1 isoform X30
XM_047437142.1 → XP_047293098.1 nuclear receptor corepressor 1 isoform X35
XM_047437127.1 → XP_047293083.1 nuclear receptor corepressor 1 isoform X14
XM_047437130.1 → XP_047293086.1 nuclear receptor corepressor 1 isoform X18
XM_047437126.1 → XP_047293082.1 nuclear receptor corepressor 1 isoform X12
XM_005256868.6 → XP_005256925.1 nuclear receptor corepressor 1 isoform X2

See identical proteins and their annotated locations for XP_005256925.1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

cd00167
Location:636 → 679

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:692 → 866

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_017025420.3 → XP_016880909.1 nuclear receptor corepressor 1 isoform X38

UniProtKB/TrEMBL

Q7Z516
XM_017025417.3 → XP_016880906.1 nuclear receptor corepressor 1 isoform X20

UniProtKB/TrEMBL

Q7Z516
XM_005256873.6 → XP_005256930.1 nuclear receptor corepressor 1 isoform X9

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_047437139.1 → XP_047293095.1 nuclear receptor corepressor 1 isoform X31
XM_047437137.1 → XP_047293093.1 nuclear receptor corepressor 1 isoform X29
XM_047437143.1 → XP_047293099.1 nuclear receptor corepressor 1 isoform X37
XM_017025419.3 → XP_016880908.1 nuclear receptor corepressor 1 isoform X34

UniProtKB/TrEMBL

Q7Z516
XM_047437131.1 → XP_047293087.1 nuclear receptor corepressor 1 isoform X19
XM_017025415.3 → XP_016880904.1 nuclear receptor corepressor 1 isoform X13

UniProtKB/TrEMBL

Q7Z516
XM_047437129.1 → XP_047293085.1 nuclear receptor corepressor 1 isoform X17
XM_005256874.6 → XP_005256931.1 nuclear receptor corepressor 1 isoform X11

UniProtKB/TrEMBL

A0A994J5B8, Q7Z516

Related

ENSP00000516022.1, ENST00000704745.1

Conserved Domains (4) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam05285
Location:688 → 770

SDA1; SDA1

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_047437135.1 → XP_047293091.1 nuclear receptor corepressor 1 isoform X25
XM_005256875.5 → XP_005256932.1 nuclear receptor corepressor 1 isoform X22

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam05285
Location:688 → 770

SDA1; SDA1

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_017025418.3 → XP_016880907.1 nuclear receptor corepressor 1 isoform X27

UniProtKB/TrEMBL

Q7Z516
XM_047437136.1 → XP_047293092.1 nuclear receptor corepressor 1 isoform X28
XM_011524085.4 → XP_011522387.1 nuclear receptor corepressor 1 isoform X26

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam05285
Location:688 → 770

SDA1; SDA1

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_047437124.1 → XP_047293080.1 nuclear receptor corepressor 1 isoform X8
XM_011524084.4 → XP_011522386.1 nuclear receptor corepressor 1 isoform X3

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam05285
Location:688 → 770

SDA1; SDA1

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_006721603.5 → XP_006721666.1 nuclear receptor corepressor 1 isoform X7

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

smart00717
Location:637 → 682

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:637 → 680

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam05285
Location:688 → 770

SDA1; SDA1

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_005256866.6 → XP_005256923.1 nuclear receptor corepressor 1 isoform X1

See identical proteins and their annotated locations for XP_005256923.1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:449 → 491

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:637 → 680

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:733 → 929

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_017025409.3 → XP_016880898.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459, Q7Z516

Conserved Domains (3) summary

cd00167
Location:627 → 670

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:683 → 857

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_017025403.3 → XP_016880892.1 nuclear receptor corepressor 1 isoform X4

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

cd00167
Location:628 → 671

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:684 → 858

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_006721602.5 → XP_006721665.1 nuclear receptor corepressor 1 isoform X2

See identical proteins and their annotated locations for XP_006721665.1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

cd00167
Location:636 → 679

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:692 → 866

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_006721601.5 → XP_006721664.1 nuclear receptor corepressor 1 isoform X1

See identical proteins and their annotated locations for XP_006721664.1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:449 → 491

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:637 → 680

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:733 → 929

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_017025401.3 → XP_016880890.1 nuclear receptor corepressor 1 isoform X2

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

cd00167
Location:636 → 679

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:692 → 866

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_017025397.3 → XP_016880886.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:449 → 491

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:637 → 680

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:733 → 929

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_047437123.1 → XP_047293079.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459
XM_047437121.1 → XP_047293077.1 nuclear receptor corepressor 1 isoform X4
XM_017025400.3 → XP_016880889.1 nuclear receptor corepressor 1 isoform X2

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (3) summary

cd00167
Location:636 → 679

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:150 → 237

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl26247
Location:692 → 866

DNA_pol3_delta2; DNA polymerase III, delta subunit
XM_017025396.3 → XP_016880885.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

Q7Z516

Conserved Domains (4) summary

cd00167
Location:449 → 491

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:637 → 680

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:149 → 238

GPS2_interact; G-protein pathway suppressor 2-interacting domain

NF033845
Location:733 → 929

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

15931369..16117845 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054317954.1 → XP_054173929.1 nuclear receptor corepressor 1 isoform X36
XM_054317934.1 → XP_054173909.1 nuclear receptor corepressor 1 isoform X16
XM_054317922.1 → XP_054173897.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459
XM_054317951.1 → XP_054173926.1 nuclear receptor corepressor 1 isoform X33
XM_054317941.1 → XP_054173916.1 nuclear receptor corepressor 1 isoform X23
XM_054317933.1 → XP_054173908.1 nuclear receptor corepressor 1 isoform X15
XM_054317921.1 → XP_054173896.1 nuclear receptor corepressor 1 isoform X5
XM_054317918.1 → XP_054173893.1 nuclear receptor corepressor 1 isoform X4
XM_054317950.1 → XP_054173925.1 nuclear receptor corepressor 1 isoform X32
XM_054317942.1 → XP_054173917.1 nuclear receptor corepressor 1 isoform X24
XM_054317939.1 → XP_054173914.1 nuclear receptor corepressor 1 isoform X21
XM_054317928.1 → XP_054173903.1 nuclear receptor corepressor 1 isoform X10
XM_054317957.1 → XP_054173932.1 nuclear receptor corepressor 1 isoform X39
XM_054317948.1 → XP_054173923.1 nuclear receptor corepressor 1 isoform X30
XM_054317953.1 → XP_054173928.1 nuclear receptor corepressor 1 isoform X35
XM_054317932.1 → XP_054173907.1 nuclear receptor corepressor 1 isoform X14
XM_054317936.1 → XP_054173911.1 nuclear receptor corepressor 1 isoform X18
XM_054317930.1 → XP_054173905.1 nuclear receptor corepressor 1 isoform X12
XM_054317913.1 → XP_054173888.1 nuclear receptor corepressor 1 isoform X2
XM_054317956.1 → XP_054173931.1 nuclear receptor corepressor 1 isoform X38
XM_054317938.1 → XP_054173913.1 nuclear receptor corepressor 1 isoform X20
XM_054317927.1 → XP_054173902.1 nuclear receptor corepressor 1 isoform X9
XM_054317949.1 → XP_054173924.1 nuclear receptor corepressor 1 isoform X31
XM_054317947.1 → XP_054173922.1 nuclear receptor corepressor 1 isoform X29
XM_054317955.1 → XP_054173930.1 nuclear receptor corepressor 1 isoform X37
XM_054317952.1 → XP_054173927.1 nuclear receptor corepressor 1 isoform X34
XM_054317937.1 → XP_054173912.1 nuclear receptor corepressor 1 isoform X19
XM_054317931.1 → XP_054173906.1 nuclear receptor corepressor 1 isoform X13
XM_054317935.1 → XP_054173910.1 nuclear receptor corepressor 1 isoform X17
XM_054317929.1 → XP_054173904.1 nuclear receptor corepressor 1 isoform X11

UniProtKB/TrEMBL

A0A994J5B8
XM_054317943.1 → XP_054173918.1 nuclear receptor corepressor 1 isoform X25
XM_054317940.1 → XP_054173915.1 nuclear receptor corepressor 1 isoform X22
XM_054317945.1 → XP_054173920.1 nuclear receptor corepressor 1 isoform X27
XM_054317946.1 → XP_054173921.1 nuclear receptor corepressor 1 isoform X28
XM_054317944.1 → XP_054173919.1 nuclear receptor corepressor 1 isoform X26
XM_054317926.1 → XP_054173901.1 nuclear receptor corepressor 1 isoform X8
XM_054317914.1 → XP_054173889.1 nuclear receptor corepressor 1 isoform X3
XM_054317925.1 → XP_054173900.1 nuclear receptor corepressor 1 isoform X7
XM_054317909.1 → XP_054173884.1 nuclear receptor corepressor 1 isoform X1
XM_054317923.1 → XP_054173898.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459
XM_054317919.1 → XP_054173894.1 nuclear receptor corepressor 1 isoform X4
XM_054317915.1 → XP_054173890.1 nuclear receptor corepressor 1 isoform X2
XM_054317910.1 → XP_054173885.1 nuclear receptor corepressor 1 isoform X1
XM_054317917.1 → XP_054173892.1 nuclear receptor corepressor 1 isoform X2
XM_054317912.1 → XP_054173887.1 nuclear receptor corepressor 1 isoform X1
XM_054317924.1 → XP_054173899.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

H0Y459
XM_054317920.1 → XP_054173895.1 nuclear receptor corepressor 1 isoform X4
XM_054317916.1 → XP_054173891.1 nuclear receptor corepressor 1 isoform X2
XM_054317911.1 → XP_054173886.1 nuclear receptor corepressor 1 isoform X1