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    HNRNPF heterogeneous nuclear ribonucleoprotein F [ Homo sapiens (human) ]

    Gene ID: 3185, updated on 9-Jan-2022

    Summary

    Official Symbol
    HNRNPFprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Fprovided by HGNC
    Primary source
    HGNC:HGNC:5039
    See related
    Ensembl:ENSG00000169813 MIM:601037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPF; mcs94-1; OK/SW-cl.23
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 61.3), appendix (RPKM 55.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See HNRNPF in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (43385618..43409186, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (43881066..43904634, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378271 Neighboring gene uncharacterized LOC107984226 Neighboring gene FXYD domain containing ion transport regulator 4 Neighboring gene small nucleolar RNA, C/D box 3J Neighboring gene zinc finger protein 487 Neighboring gene RNA, U7 small nuclear 193 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of heterogeneous nuclear ribonucleoprotein F (HNRNPF) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein F (HNRNPF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein F (HNRNPF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein F (HNRNPF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein F (HNRNPF), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein F (HNRNPF), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPF is increased by RRE PubMed
    Tat tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
    Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
    Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC110997

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein F
    Names
    HnRNP F protein
    nucleolin-like protein mcs94-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098204.2NP_001091674.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001091674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, BC001432, BC015580, DB049909
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000507787.1, ENST00000682386.1
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    2. NM_001098205.2NP_001091675.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001091675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, AK001364, BC001432, DA535143
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000348345.3, ENST00000356053.7
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    3. NM_001098206.2NP_001091676.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001091676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, BC001432, BC016736
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000349573.4, ENST00000357065.8
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    4. NM_001098207.2NP_001091677.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001091677.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, BC001432, BC106008, DA679417
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000438061.1, ENST00000544000.5
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    5. NM_001098208.2NP_001091678.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001091678.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, BC001432, CR976524
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000400433.2, ENST00000443950.6
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    6. NM_004966.4NP_004957.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_004957.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AI133166, BC001432, BC004254, DA594075
      Consensus CDS
      CCDS7204.1
      UniProtKB/Swiss-Prot
      P52597
      UniProtKB/TrEMBL
      A0A024R7T3
      Related
      ENSP00000338477.3, ENST00000337970.7
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      43385618..43409186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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