KLF10 KLF transcription factor 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF10provided by HGNC
Official Full Name: KLF transcription factor 10provided by HGNC
Primary source: HGNC:HGNC:11810
See related: Ensembl:ENSG00000155090 MIM:601878; AllianceGenome:HGNC:11810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGRA; TIEG; TIEG1; EGR-alpha
Summary: This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q22.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (102648784..102655725, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (103777028..103783970, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (103661012..103667953, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

New Insights into the Role of KLF10 in Tissue Fibrosis.
Title: New Insights into the Role of KLF10 in Tissue Fibrosis.
A TGF-beta/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
Title: A TGF-β/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
Title: KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
Kruppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
Title: Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
Transcription factor AP-2 gamma/Kruppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension.
Title: Transcription factor AP-2 gamma/Krüppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension.
KLF10 Functions as an Independent Prognosis Factor for Gastric Cancer.
Title: KLF10 Functions as an Independent Prognosis Factor for Gastric Cancer.
KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.
Title: KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.
Kruppel like factor 10 up-regulates PDZ and LIM domain containing protein 2 via nuclear factor kappa-B pathway to inhibit proliferation and inflammatory of fibroblastoid synovial cell in rheumatoid arthritis.
Title: Kruppel like factor 10 up-regulates PDZ and LIM domain containing protein 2 via nuclear factor kappa-B pathway to inhibit proliferation and inflammatory of fibroblastoid synovial cell in rheumatoid arthritis.
Positive feedback between lncRNA FLVCR1-AS1 and KLF10 may inhibit pancreatic cancer progression via the PTEN/AKT pathway.
Title: Positive feedback between lncRNA FLVCR1-AS1 and KLF10 may inhibit pancreatic cancer progression via the PTEN/AKT pathway.
KLF10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microRNA-106b-5p.
Title: KLF10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microRNA-106b-5p.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of Kruppel-like factor 10 (KLF10) in human B cells	PubMed
Tat	tat	The gene expression of Krueppel-like factor 10 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC30492 (e-PCR)
- UniSTS:22328

A006S39 (e-PCR)
- UniSTS:42147

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Krueppel-like factor 10

Names: Kruppel like factor 10; TGFB-inducible early growth response protein 1; early growth response-alpha; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor TIEG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033271.1 RefSeqGene

Range

5178..12119

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_758

mRNA and Protein(s)

NM_001032282.4 → NP_001027453.1 Krueppel-like factor 10 isoform b

See identical proteins and their annotated locations for NP_001027453.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AP002851, BC095399, BQ575313, S81439

Consensus CDS

CCDS47905.1

UniProtKB/Swiss-Prot

Q13118

Related

ENSP00000379222.3, ENST00000395884.3

Conserved Domains (4) summary

COG5048
Location:363 → 413

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:363 → 382

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:418 → 440

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:404 → 427

zf-H2C2_2; Zinc-finger double domain
NM_005655.4 → NP_005646.1 Krueppel-like factor 10 isoform a

See identical proteins and their annotated locations for NP_005646.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AP002851, BC095399, BQ575313, DA720479

Consensus CDS

CCDS6294.1

UniProtKB/Swiss-Prot

A8MVH0, B2R794, L0R4P6, L0R679, O75411, Q13118, Q503B2

Related

ENSP00000285407.6, ENST00000285407.11

Conserved Domains (4) summary

COG5048
Location:374 → 424

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:374 → 393

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:429 → 451

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:415 → 438

zf-H2C2_2; Zinc-finger double domain

RNA

NR_103759.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks the 5' exon and an internal exon, and contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.

Source sequence(s)

AP002851, BC095399, BQ575313, DA756360, HF546211
NR_103760.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks the 5' exon, contains an alternate 5' exon, and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because use of translational start codon used in variant 2 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AP002851, BC095399, BQ575313, DA756360, HF546210