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    SLCO5A1 solute carrier organic anion transporter family member 5A1 [ Homo sapiens (human) ]

    Gene ID: 81796, updated on 17-Jan-2022

    Summary

    Official Symbol
    SLCO5A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 5A1provided by HGNC
    Primary source
    HGNC:HGNC:19046
    See related
    Ensembl:ENSG00000137571 MIM:613543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15
    Summary
    This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in small intestine (RPKM 68.6), ovary (RPKM 66.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLCO5A1 in Genome Data Viewer
    Location:
    8q13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (69667046..69835064, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70579281..70747213, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1603 Neighboring gene sulfatase 1 Neighboring gene uncharacterized LOC105375889 Neighboring gene RN7SK pseudogene 29 Neighboring gene thioredoxin related transmembrane protein 1 pseudogene Neighboring gene uncharacterized LOC101929759 Neighboring gene BAG cochaperone 4 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 675, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variation and the control of HIV-1 in humans.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39560

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 5A1
    Names
    organic anion transporter polypeptide-related protein 4
    solute carrier family 21 (organic anion transporter), member 15
    solute carrier family 21 member 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146008.2NP_001139480.1  solute carrier organic anion transporter family member 5A1 isoform 2

      See identical proteins and their annotated locations for NP_001139480.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC079089, AC091047, AF205075, AK022760, CA449383
      Consensus CDS
      CCDS55243.1
      UniProtKB/Swiss-Prot
      Q9H2Y9
      Related
      ENSP00000434422.1, ENST00000524945.5
      Conserved Domains (3) summary
      cd06174
      Location:131531
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:551605
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:129674
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_001146009.1NP_001139481.1  solute carrier organic anion transporter family member 5A1 isoform 3

      See identical proteins and their annotated locations for NP_001139481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AC079089, AC091047, AF205075, BC139755, CA449383
      Consensus CDS
      CCDS55242.1
      UniProtKB/Swiss-Prot
      Q9H2Y9
      Related
      ENSP00000431611.1, ENST00000530307.1
      Conserved Domains (3) summary
      cd06174
      Location:131368
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:496550
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:129679
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. NM_030958.3NP_112220.2  solute carrier organic anion transporter family member 5A1 isoform 1

      See identical proteins and their annotated locations for NP_112220.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC091047, AK096879, BC137424, CA449383
      Consensus CDS
      CCDS6205.1
      UniProtKB/Swiss-Prot
      Q9H2Y9
      UniProtKB/TrEMBL
      B3KUC7
      Related
      ENSP00000260126.3, ENST00000260126.9
      Conserved Domains (3) summary
      cd06174
      Location:131531
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:551605
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:129734
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      69667046..69835064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251313.2XP_005251370.1  solute carrier organic anion transporter family member 5A1 isoform X1

      See identical proteins and their annotated locations for XP_005251370.1

      UniProtKB/Swiss-Prot
      Q9H2Y9
      Conserved Domains (3) summary
      cd06174
      Location:131368
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:496550
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:129679
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. XM_017013883.1XP_016869372.1  solute carrier organic anion transporter family member 5A1 isoform X2

      UniProtKB/Swiss-Prot
      Q9H2Y9
      Conserved Domains (3) summary
      cd06174
      Location:131531
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:551605
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:129674
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. XM_017013885.1XP_016869374.1  solute carrier organic anion transporter family member 5A1 isoform X4

    4. XM_017013884.1XP_016869373.1  solute carrier organic anion transporter family member 5A1 isoform X3

    5. XM_017013886.1XP_016869375.1  solute carrier organic anion transporter family member 5A1 isoform X5

    RNA

    1. XR_928814.1 RNA Sequence

    2. XR_428341.2 RNA Sequence

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