CYP2W1 cytochrome P450 family 2 subfamily W member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP2W1provided by HGNC
Official Full Name: cytochrome P450 family 2 subfamily W member 1provided by HGNC
Primary source: HGNC:HGNC:20243
See related: Ensembl:ENSG00000073067 MIM:615967; AllianceGenome:HGNC:20243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
Expression: Biased expression in skin (RPKM 2.9), duodenum (RPKM 2.7) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p22.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (983181..989640)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (1088177..1094636)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (1022817..1029276)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.
Title: CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer.
showed that the genetic pattern of CYP2W1 is interethnically different among the three Chinese populations, and this finding can extend our understanding of population genetics of CYP2W1 in the Chinese population
Title: Identification of Genetic Polymorphisms of CYP2W1 in the Three Main Chinese Ethnicities: Han, Tibetan, and Uighur.
summarizes the history, distribution, polymorphism, membrane topology, function and possible role in cancer therapy of CYP2W1.
Title: The CYP2W1 enzyme: regulation, properties and activation of prodrugs.
Normal adrenal tissue lacks CYP2W1 enzyme expression; adrenocortical carcinomas generally do not express the enzyme as well.
Title: Human Cytochrome P450 2W1 Is Not Expressed in Adrenal Cortex and Is Only Rarely Expressed in Adrenocortical Carcinomas.
Report novel SNPs of CYP2W1 gene in Chinese Uygur and Han populations.
Title: Novel single nucleotide polymorphisms (SNPs) of CYP2W1 gene in Chinese Uygur and Han populations.
Data suggest that canonical cytochrome P-450 reductants (cytochrome P450 reductase; cytochrome b5) cannot serve as electron donors for CYP2W1, a colon tumor-specific enzyme; glycosylation of CYP2W1 at Asn177 is required for full catalytic activity.
Title: Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.
Results show the developmental expression of CYP2W1 in the GI tract mediated by epigenetic modifications, its specific location, and regulation by anticancer drugs which can be considered as an adjuvant therapy of colon and hepatic cancers.
Title: Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.
Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
Title: KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.
CYP2W1 is highly expressed in both normal and neoplastic adrenal glands making it a promising tool for targeted therapy in ACC
Title: CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma.
High CYP2W1 expression is seen in 26% of primary colorectal tumors and in 48% of corresponding liver metastases.
Title: The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables all-trans retinal binding	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid 4-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in aflatoxin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cytochrome metabolic process	TAS Traceable Author Statement more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2W1

Names: CYPIIW1; cytochrome P450, family 2, subfamily W, polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007934.1 RefSeqGene

Range

4983..11442

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_017781.3 → NP_060251.2 cytochrome P450 2W1 precursor

See identical proteins and their annotated locations for NP_060251.2

Status: REVIEWED

Source sequence(s)

AC073957, BC025761

Consensus CDS

CCDS5319.2

UniProtKB/Swiss-Prot

Q8TAV3

Related

ENSP00000310149.7, ENST00000308919.12

Conserved Domains (1) summary

pfam00067
Location:32 → 479

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

983181..989640

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515441.4 → XP_011513743.1 cytochrome P450 2W1 isoform X2

Conserved Domains (1) summary

pfam00067
Location:32 → 462

p450; Cytochrome P450
XM_011515440.4 → XP_011513742.1 cytochrome P450 2W1 isoform X1

Conserved Domains (1) summary

pfam00067
Location:32 → 452

p450; Cytochrome P450