LYPLA2 lysophospholipase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LYPLA2provided by HGNC
Official Full Name: lysophospholipase 2provided by HGNC
Primary source: HGNC:HGNC:6738
See related: Ensembl:ENSG00000011009 MIM:616143; AllianceGenome:HGNC:6738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APT2; APT-2; DJ886K2.4
Summary: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (23791145..23795539)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23626121..23630514)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (24117635..24122029)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Title: Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
LYPLA1 and LYPLA2 are each able to account for the loss of the other to maintain lipid homeostasis in cells
Title: Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.
Here, we describe the conserved functions of APT1 and APT2 across organisms and discuss the possibility that these enzymes are members of a larger family of depalmitoylation enzymes.
Title: Enzymatic protein depalmitoylation by acyl protein thioesterases.
LYPLA2 is the major prostaglandin glycerol ester hydrolase in human cancer cells.
Title: Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
Title: Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
Results demonstrate that APT-2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution.
Title: Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74383 (e-PCR)
- UniSTS:77868

RH8138 (e-PCR)
- UniSTS:87151

G23097 (e-PCR)
- UniSTS:69099

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-(protein) hydrolase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	TAS Traceable Author Statement more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein depalmitoylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: acyl-protein thioesterase 2

Names: LPL-II; lysoPLA II; lysophospholipase II; palmitoyl-protein hydrolase; testicular tissue protein Li 3

NP_009191.1

EC 3.1.2.22

XP_005245785.1

EC 3.1.2.22

XP_054190020.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007260.3 → NP_009191.1 acyl-protein thioesterase 2

See identical proteins and their annotated locations for NP_009191.1

Status: REVIEWED

Source sequence(s)

AL031295

Consensus CDS

CCDS241.1

UniProtKB/Swiss-Prot

O95372, Q7Z4Z2

UniProtKB/TrEMBL

A0A140VJC9

Related

ENSP00000363638.3, ENST00000374514.8

Conserved Domains (1) summary

pfam02230
Location:11 → 228

Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

23791145..23795539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005245728.6 → XP_005245785.1 acyl-protein thioesterase 2 isoform X1

Conserved Domains (1) summary

pfam02230
Location:26 → 240

Abhydrolase_2; Phospholipase/Carboxylesterase