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    FASTKD1 FAST kinase domains 1 [ Homo sapiens (human) ]

    Gene ID: 79675, updated on 23-Nov-2021

    Summary

    Official Symbol
    FASTKD1provided by HGNC
    Official Full Name
    FAST kinase domains 1provided by HGNC
    Primary source
    HGNC:HGNC:26150
    See related
    Ensembl:ENSG00000138399 MIM:617529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in heart (RPKM 4.3), duodenum (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FASTKD1 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169527880..169573916, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170385018..170430375, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 5 Neighboring gene kelch like family member 41 Neighboring gene peptidylprolyl isomerase G Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene cilia and flagella associated protein 210

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21901, KIAA1800

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mitochondrial mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    FAST kinase domain-containing protein 1, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281476.3NP_001268405.1  FAST kinase domain-containing protein 1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB058703, AK055892, AL832058, CA449468, DA650481
      Consensus CDS
      CCDS63051.1
      UniProtKB/Swiss-Prot
      Q53R41
      Related
      ENSP00000403229.2, ENST00000453929.6
      Conserved Domains (3) summary
      smart00952
      Location:736795
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:575642
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:657699
      FAST_2; FAST kinase-like protein, subdomain 2
    2. NM_001322046.2NP_001308975.1  FAST kinase domain-containing protein 1, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB058703, AC093899, AK055892, AL832058, CA449468, DA650481
      Consensus CDS
      CCDS33318.1
      UniProtKB/Swiss-Prot
      Q53R41
      Conserved Domains (3) summary
      smart00952
      Location:779838
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:575642
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:662742
      FAST_2; FAST kinase-like protein, subdomain 2
    3. NM_001322048.2NP_001308977.1  FAST kinase domain-containing protein 1, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB058703, AK055892, AL832058, CA449468, DA650481
      UniProtKB/Swiss-Prot
      Q53R41
      UniProtKB/TrEMBL
      D3DPC4
      Conserved Domains (3) summary
      smart00952
      Location:756815
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:552619
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:639719
      FAST_2; FAST kinase-like protein, subdomain 2
    4. NM_001322049.2NP_001308978.1  FAST kinase domain-containing protein 1, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AB058703, AK055892, AL832058, BC017950, BC032687, CA449468, DA650481
      UniProtKB/Swiss-Prot
      Q53R41
      UniProtKB/TrEMBL
      Q05D57
      Conserved Domains (3) summary
      smart00952
      Location:713772
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:552619
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:634676
      FAST_2; FAST kinase-like protein, subdomain 2
    5. NM_024622.6NP_078898.3  FAST kinase domain-containing protein 1, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_078898.3

      Status: VALIDATED

      Source sequence(s)
      AB058703, AK055892, AL832058, CA449468, DA650481
      Consensus CDS
      CCDS33318.1
      UniProtKB/Swiss-Prot
      Q53R41
      Related
      ENSP00000400513.2, ENST00000453153.7
      Conserved Domains (3) summary
      smart00952
      Location:779838
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:575642
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:662742
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. NR_104020.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB058703, AK055892, AK130797, AL832058, CA449468, DA650481

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      169527880..169573916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004912.2XP_016860401.1  FAST kinase domain-containing protein 1, mitochondrial isoform X4

    2. XM_006712750.4XP_006712813.1  FAST kinase domain-containing protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006712813.1

      UniProtKB/TrEMBL
      D3DPC4
      Conserved Domains (3) summary
      smart00952
      Location:756815
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:552619
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:639719
      FAST_2; FAST kinase-like protein, subdomain 2
    3. XM_017004911.2XP_016860400.1  FAST kinase domain-containing protein 1, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q53R41
      Conserved Domains (3) summary
      smart00952
      Location:607666
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:403470
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:490570
      FAST_2; FAST kinase-like protein, subdomain 2
    4. XM_006712751.4XP_006712814.1  FAST kinase domain-containing protein 1, mitochondrial isoform X3

      Conserved Domains (3) summary
      smart00952
      Location:459518
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:255322
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:342422
      FAST_2; FAST kinase-like protein, subdomain 2
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