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    LGR4 leucine rich repeat containing G protein-coupled receptor 4 [ Homo sapiens (human) ]

    Gene ID: 55366, updated on 9-Jan-2022

    Summary

    Official Symbol
    LGR4provided by HGNC
    Official Full Name
    leucine rich repeat containing G protein-coupled receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:13299
    See related
    Ensembl:ENSG00000205213 MIM:606666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPSL; GPR48; BNMD17
    Summary
    The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in kidney (RPKM 28.0), colon (RPKM 27.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LGR4 in Genome Data Viewer
    Location:
    11p14.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (27365961..27472790, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27387508..27494337, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376601 Neighboring gene coiled-coil domain containing 34 Neighboring gene Sharpr-MPRA regulatory region 4633 Neighboring gene LGR4 antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Bone mineral density quantitative trait locus 17
    MedGen: C3714987 OMIM: 615311 GeneReviews: Not available
    not available
    DELAYED PUBERTY, SELF-LIMITED
    MedGen: CN301235 OMIM: 619613 GeneReviews: Not available
    not available
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    GeneReviews: Not available
    Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in canonical Wnt signaling pathway involved in metanephric kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation involved in metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell proliferation involved in renal tubule morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric nephron tubule morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 4
    Names
    G protein-coupled receptor 48

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051818.1 RefSeqGene

      Range
      5001..111815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346432.2NP_001333361.1  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC090597, AC100771
      Consensus CDS
      CCDS86187.1
      UniProtKB/Swiss-Prot
      Q9BXB1
      UniProtKB/TrEMBL
      Q59ER8
      Related
      ENSP00000374508.4, ENST00000389858.4
    2. NM_018490.5NP_060960.2  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_060960.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090597, AC100771
      Consensus CDS
      CCDS31449.1
      UniProtKB/Swiss-Prot
      Q9BXB1
      UniProtKB/TrEMBL
      Q59ER8
      Related
      ENSP00000368516.4, ENST00000379214.9
      Conserved Domains (5) summary
      cd00116
      Location:44239
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5982
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:556801
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01462
      Location:2956
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:177237
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      27365961..27472790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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