NCBI Homo sapiens Updated Annotation Release 109.20210514

The RefSeq genome records for Homo sapiens were annotated by the NCBI Eukaryotic Genome Annotation Pipeline, an automated pipeline that annotates genes, transcripts and proteins on draft and finished genome assemblies.

Updated Annotation Release 109.20210514 is an update of NCBI Homo sapiens Annotation Release 109. The known RefSeq transcripts (with NM_ and NR_ prefixes) that were current on May 14 2021 were placed on the genome and used to update the annotated features. In addition, model RefSeq predicted in the last full annotation (Annotation Release 109) that were still current on May 14 2021 were included in the updated annotation. These models were not re-calculated for this update. For more information on the evidence used for generating the model RefSeq, please consult the report for NCBI Homo sapiens Annotation Release 109.

The annotation products are available in the sequence databases and on the FTP site.

This report provides:

For more information on the annotation process, please visit the NCBI Eukaryotic Genome Annotation Pipeline page.


Annotation Release information

This annotation should be referred to as NCBI Homo sapiens Updated Annotation Release 109.20210514

Annotation release ID: 109.20210514
Date of Entrez queries for transcripts and proteins: May 14 2021
Date of submission of annotation to the public databases: May 16 2021
Software version: 8.6

Assemblies

The following assemblies were included in this annotation run:
Assembly nameAssembly accessionSubmitterAssembly dateReference/AlternateAssembly content
GRCh38.p13GCF_000001405.39Genome Reference Consortium02-28-2019Reference25 assembled chromosomes; unplaced scaffolds

Gene and feature statistics

Counts and length of annotated features are provided below for each assembly.

Feature counts

FeatureGRCh38.p13GRCh38.p13
Primary Assembly
GRCh38.p13
All Alt Loci
GRCh38.p13
PATCHES
Genes and pseudogenes help54,58554,2862,4111,573
  protein-coding19,52719,447816596
  non-coding18,19718,054686406
  Transcribed pseudogenes1,1951,18810696
  Non-transcribed pseudogenes15,25015,190635448
  genes with variants19,95919,888615395
  Immunoglobulin/T-cell receptor gene segments39738816122
  other191975
  placed on multiple assembly-units help3,509na666na
mRNAs116,250116,0482,1121,525
  fully-supported116,174115,9782,1071,524
  with > 5% ab initio help464330
  partial2834309198
  with filled gap(s) help0000
  placed on multiple assembly-units help3,285na774na
  known RefSeq (NM_) help62,30362,2152,0291,494
  model RefSeq (XM_)53,94753,8338331
non-coding RNAs help48,37446,5191,860798
  fully-supported46,47745,1151,557769
  with > 5% ab initio help0000
  partial777138
  with filled gap(s) help0000
  placed on multiple assembly-units help792na202na
  known RefSeq (NR_) help17,01817,012578392
  model RefSeq (XR_) help29,48628,129980377
pseudo transcripts help1,5981,583126108
  fully-supported1,5871,574124108
  with > 5% ab initio help0000
  partial111510
  with filled gap(s) help0000
  placed on multiple assembly-units helpnananana
  known RefSeq (NR_) help1,4701,464119106
  model RefSeq (XR_) help12811972
CDSs116,837116,4372,2671,532
  fully-supported116,174115,9782,1071,524
  with > 5% ab initio help585341
  partial507342382177
  with major correction(s) help45604185
  known RefSeq (NP_) help62,30362,2152,0211,479
  model RefSeq (XP_) help53,96053,8338331

Detailed reports

The counts below do not include pseudogenes.

BUSCO analysis of gene annotation

BUSCO v4.0.2 (Simão et al 2015, PMID: 26059717) was run in "protein" mode on the annotated gene set picking one longest protein per gene, and run using the primates_odb10 lineage dataset. Results are reported for the gene set from the primary assembly unit, and presented in BUSCO notation (C:complete [S:single-copy, D:duplicated], F:fragmented, M:missing, n:number of genes used).

References

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