NCBI Homo sapiens Updated Annotation Release 109.20211119

The RefSeq genome records for Homo sapiens were annotated by the NCBI Eukaryotic Genome Annotation Pipeline, an automated pipeline that annotates genes, transcripts and proteins on draft and finished genome assemblies.

Updated Annotation Release 109.20211119 is an update of NCBI Homo sapiens Annotation Release 109. The known RefSeq transcripts (with NM_ and NR_ prefixes) that were current on Nov 19 2021 were placed on the genome and used to update the annotated features. In addition, model RefSeq predicted in the last full annotation (Annotation Release 109) that were still current on Nov 19 2021 were included in the updated annotation. These models were not re-calculated for this update. For more information on the evidence used for generating the model RefSeq, please consult the report for NCBI Homo sapiens Annotation Release 109.

The annotation products are available in the sequence databases and on the FTP site.

This report provides:

For more information on the annotation process, please visit the NCBI Eukaryotic Genome Annotation Pipeline page.


Annotation Release information

This annotation should be referred to as NCBI Homo sapiens Updated Annotation Release 109.20211119

Annotation release ID: 109.20211119
Date of Entrez queries for transcripts and proteins: Nov 19 2021
Date of submission of annotation to the public databases: Nov 22 2021
Software version: 9.0

Assemblies

The following assemblies were included in this annotation run:
Assembly nameAssembly accessionSubmitterAssembly dateReference/AlternateAssembly content
GRCh38.p13GCF_000001405.39Genome Reference Consortium02-28-2019Reference25 assembled chromosomes; unplaced scaffolds

Gene and feature statistics

Counts and length of annotated features are provided below for each assembly.

Feature counts

FeatureGRCh38.p13GRCh38.p13
Primary Assembly
GRCh38.p13
All Alt Loci
GRCh38.p13
PATCHES
Genes and pseudogenes help54,63054,3322,4121,577
  protein-coding19,55819,480821601
  non-coding18,18418,038687405
  Transcribed pseudogenes1,2161,21110595
  Non-transcribed pseudogenes15,22715,167631447
  genes with variants19,92119,850620400
  Immunoglobulin/T-cell receptor gene segments39738816122
  other484877
  placed on multiple assembly-units help3,515na666na
mRNAs115,338115,1282,1481,562
  fully-supported115,265115,0612,1431,561
  with > 5% ab initio help434030
  partial2632308200
  with filled gap(s) help0000
  placed on multiple assembly-units help3,345na780na
  known RefSeq (NM_) help62,78262,6972,0531,532
  model RefSeq (XM_)52,55652,4319530
non-coding RNAs help48,22046,3591,871798
  fully-supported46,32244,9541,568769
  with > 5% ab initio help0000
  partial887138
  with filled gap(s) help0000
  placed on multiple assembly-units help797na201na
  known RefSeq (NR_) help17,11417,106585392
  model RefSeq (XR_) help29,23627,875984377
pseudo transcripts help1,6891,676128107
  fully-supported1,6781,667126107
  with > 5% ab initio help0000
  partial001510
  with filled gap(s) help0000
  placed on multiple assembly-units helpnananana
  known RefSeq (NR_) help1,5601,556121105
  model RefSeq (XR_) help12912072
CDSs115,925115,5172,3031,569
  fully-supported115,265115,0612,1431,561
  with > 5% ab initio help555041
  partial507342381179
  with major correction(s) help44604184
  known RefSeq (NP_) help62,78262,6972,0451,517
  model RefSeq (XP_) help52,56952,4319530

Detailed reports

The counts below do not include pseudogenes.

BUSCO analysis of gene annotation

BUSCO v4.1.4 (Simão et al 2015, PMID: 26059717) was run in "protein" mode on the annotated gene set picking one longest protein per gene, and run using the primates_odb10 lineage dataset. Results are reported for the gene set from the primary assembly unit, and presented in BUSCO notation (C:complete [S:single-copy, D:duplicated], F:fragmented, M:missing, n:number of genes used).

References

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