Project overview

 The HIV-1, human interactions project collates published reports of two types of interactions - protein interactions, and human gene knock-downs that affect virus replication and infectivity (reported as 'replication interactions').  Documenting the interaction of human immunodeficiency virus type 1 (HIV-1) with the host cell is crucial to understanding the process of HIV-1 replication and pathogenesis, and provides an essential foundation for the development of safe and effective therapeutic and prevention strategies to combat AIDS.

Although numerous interactions have been reported in the scientific literature there is currently no publicly available source for efficiently accessing this information. Therefore, the Division of Acquired Immunodeficiency Syndrome (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID) has initiated a project, in collaboration with Southern Research Institute and the National Center for Biotechnology Information (NCBI), designed to compile a comprehensive database of the described interactions between HIV-1 and human genes and cellular proteins.

The goal of this project is to provide scientists in the field of HIV/AIDS research a concise, yet detailed, summary of all known interactions of HIV-1 and the human host including human genes that have been reported to affect viral replication and infectivity, interactions between HIV-1 proteins with host cell proteins, other HIV-1 proteins, or proteins from disease organisms associated with HIV/AIDS. To this end, the database has been designed to track the following information for interactions identified in the literature:

  • NCBI Reference Sequence (RefSeq) protein accession numbers.
  • NCBI Entrez Gene ID numbers.
  • Amino acids from each protein that are known to be involved in the interaction.
  • Brief description of the protein or replication interaction.
  • Keywords to support searching for interactions.
  • National Library of Medicine (NLM) PubMed identification numbers (PMIDs) for all journal articles describing the interaction.

How to cite:

Please use these articles to cite use of the HIV-1, human protein interaction dataset and web resources:

transparent.gifHuman immunodeficiency virus type 1, human protein interaction database at NCBI
transparent.gifFu, W., Sanders-Beer, B.E., Katz, K.S., Maglott, D.R., Pruitt, K.D., Ptak, R.G.
transparent.gifNucleic Acids Research 2009; 37(Database issue):D417-22
transparent.gifDOI: 10.1093/nar/gkn708; transparent.gifPDF,transparent.gif PubMed ID: 18927109

transparent.gifCataloguing the HIV-1 Human Protein Interaction Network.
transparent.gifPtak, R.G., Fu, W., Sanders-Beer, B.E., Dickerson, J.E., Pinney, J.W., Robertson, D.L.,
transparent.gif Rozanov, M.N., Katz, K.S., Maglott, D.R., Pruitt, K.D., Dieffenbach, C.W.
transparent.gifAIDS Research and Human Retroviruses 2008; 24(12):1497-502
transparent.gifDOI:10.1089/aid.2008.0113;transparent.gifPDF transparent.gif PubMed ID: 19025396 transparent.gif Supplemental Data (PDF) transparent.gif PubMed Central

transparent.gifHIV-host interactions: a map of viral perturbation of the host system.
transparent.gifPinney, J.W.; Dickerson, J.E.; Fu, W.; Sanders-Beer, B.E.; Ptak, R.G.; Robertson, D.L.
transparent.gifAIDS 2009; 23(5):549-554.
transparent.gifDOI:10.1097/QAD.0b013e328325a495transparent.gifPubMed ID: 19262354

Acknowledgements and Contacts:

The initial review of the scientific literature and development of the database was performed by Mr. Roger Ptak, Dr. William Fu, and Dr. Brigitte Beer (Southern Research Institute, Frederick, Maryland). The work was supported by NIH contracts N01-AI-05415, Specialized In Vitro Virological Evaluations Of Strategies To Combat HIV/AIDS, and N01-AI-70042, In Vitro Testing Resources for AIDS Therapeutic Development Part B: Specialized In Vitro Virological Assays for HIV Therapeutics and Topical Microbicides, under direction of Dr. Roger Miller, Project Officer, DAIDS, NIAID. DAIDS gratefully acknowledges the efforts of Dr. Kim Pruitt, Dr. Donna Maglott, Mr. Craig Wallin, and Dr. Ken Katz (NCBI, NLM) for linking the database to NCBI programs and overseeing the updating of the database.

Last updated: 2016-06-28T14:39:43-04:00