With its increasing importance as a human pathogen, the study of the
Aspergillus fumigatus genome became a priority. Recent studies show that the frequency of aspergillosis invasive disease has risen approximately 14-fold over the past 12 years. Invasive aspergillosis has overtaken candidiasis as the most frequent fungal infection in the world.
More...People at risk are transplant recipients, patients with HIV/AIDS, with chronic granulomatous disease, with severe combined immunodeficiency, among others. Fungi of the genus Aspergillus are also pathogenic to other mammals. Examples of veterinary diseases include pulmonary and airsac infections in birds (particularly in chicks and turkey poults), abortion and mastitis in domestic livestock, such as cattle, and guttural pouch aspergillosis in horses.The Aspergillus fumigatus genome is estimated to be 30 Mb, organized in 8 chromosomes. The sequencing and analysis of the Aspergillus fumigatus genome will contribute to the understanding of the biology of this important human and animal pathogen, and the identification of the molecular pathology of aspergillosis. Less...- COVID-19-Associated Pulmonary Aspergillosis Isolates Are Genomically Diverse but Similar to Each Other in Their Responses to Infection-Relevant Stresses. Mead ME, et al. Microbiol Spectr 2023 Mar 22
- Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus. Steenwyk JL, et al. Microbiol Spectr 2021 Sep 3
- Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection. Barber AE, et al. Nat Microbiol 2021 Dec
- Effects of Agricultural Fungicide Use on Aspergillus fumigatus Abundance, Antifungal Susceptibility, and Population Structure. Barber AE, et al. mBio 2020 Nov 24
- Genome-wide transcriptomic analysis of a superior biomass-degrading strain of A. fumigatus revealed active lignocellulose-degrading genes. Miao Y, et al. BMC Genomics 2015 Jun 16
- Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability. Joardar V, et al. BMC Genomics 2012 Dec 12
- Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. Fedorova ND, et al. PLoS Genet 2008 Apr 11
- Identification of pathogenic Aspergillus species by a PCR-restriction enzyme method. Mirhendi H, et al. J Med Microbiol 2007 Nov
- Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nierman WC, et al. Nature 2005 Dec 22
- Genomics of Aspergillus fumigatus. Ronning CM, et al. Rev Iberoam Micol 2005 Dec
More...
Reference genome:  
Aspergillus fumigatus Af293|
Loc
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Type
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Name
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RefSeq
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INSDC
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Size (Mb)
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GC%
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Protein
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tRNA
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Gene
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Pseudogene
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|---|
| Chr | 1 | NC_007194.1 | CM000169.1 | 4.92 | 49.9 | 1,612 | 32 | 1,656 | 12 | | | Chr | 2 | NC_007195.1 | CM000170.1 | 4.84 | 49.9 | 1,624 | 25 | 1,652 | 3 | | | Chr | 3 | NC_007196.1 | CM000171.1 | 4.08 | 49.6 | 1,362 | 26 | 1,397 | 9 | | | Chr | 4 | NC_007197.1 | CM000172.1 | 3.92 | 49.9 | 1,224 | 15 | 1,252 | 13 | | | Chr | 5 | NC_007198.1 | CM000173.1 | 3.95 | 50.2 | 1,351 | 67 | 1,421 | 3 | | | Chr | 6 | NC_007199.1 | CM000174.1 | 3.78 | 49.7 | 1,227 | 28 | 1,261 | 6 | | | Chr | 7 | NC_007200.1 | CM000175.1 | 2.06 | 49.6 | 621 | 16 | 645 | 8 | | | Chr | 8 | NC_007201.1 | CM000176.1 | 1.83 | 49.4 | 609 | 19 | 631 | 3 | | | Un | - | . | - | 28.81 | 49.8 | 9,630 | 229 | 9,916 | 57 | |
Click on chromosome name to open Genome Data Viewer |