Genome

Leishmania major A flagellated protozoan that is the etiological agent of cutaneous, mucocutaneous and/or visceral leishmaniasis. Lineage: Eukaryota[15558]; Discoba[97]; Euglenozoa[89]; Kinetoplastea[84]; Metakinetoplastina[83]; Trypanosomatida[82]; Trypanosomatidae[82]; Leishmaniinae[37]; Leishmania[22]; Leishmania[9]; Leishmania major species complex[1]; Leishmania major[1]

Leishmania major is a flagellated protozoan that causes a wide spectrum of human diseases, with clinical manifestations ranging from spontaneously healing skin ulcers to severe visceral disease. The infection rate worldwide is around two million new cases per year, with one tenth of the world population at risk of infection. Leishmaniasis is More...endemic in northern and western Africa, Middle East, parts of Europe, and in Central and South America. In Sudan the disease is epidemic and has killed 10% of the population in the past five years. About 30 species of sandflies can become infected from a reservoir host. Hosts include infected humans, wild animals such as rodents, and domestic animals such as dogs. Some types of leishmaniases are zoonotic (transmitted from animals to humans), and humans become infected only when accidentally exposed to the natural transmission cycle. However, in the anthroponotic form of transmission (transmitted from human to human through the sandfly vector), humans are the sole reservoir host. Less...

Summary Sequence data:  genome assemblies: 7; sequence reads: 33  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 32.7976  median protein count: 8412  median GC%: 59.6469 Publications (limited to 20 most recent records) Gene Annotation and Transcriptome Delineation on a De Novo Genome Assembly for the Reference Leishmania major Friedlin Strain. Camacho E, et al. Genes (Basel) 2021 Aug 29 Leishmania Mitochondrial Genomes: Maxicircle Structure and Heterogeneity of Minicircles. Camacho E, et al. Genes (Basel) 2019 Sep 26 Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Rogers MB, et al. Genome Res 2011 Dec The genome of the kinetoplastid parasite, Leishmania major. Ivens AC, et al. Science 2005 Jul 15 Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene. Worthey EA, et al. Nucleic Acids Res 2003 Jul 15 Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes. Myler PJ, et al. Proc Natl Acad Sci U S A 1999 Mar 16 More...  Representative (genome information for reference and representative genomes) Reference genome:   Leishmania major strain Friedlin Submitter: Friedlin Consortium Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_001905.3 FR796397.1 0.27 63.1 85 - - - 85 - Chr 2 NC_007244.2 FR796398.1 0.36 63.0 74 - - 61 137 2 Chr 3 NC_004916.2 FR796399.1 0.38 63.0 95 - 1 - 97 1 Chr 4 NC_007245.2 FR796400.1 0.47 61.7 127 - - - 130 3 Chr 5 NC_007246.2 FR796401.1 0.47 61.9 124 1 1 32 159 1 Chr 6 NC_007247.2 FR796402.1 0.52 62.3 134 - - - 135 1 Chr 7 NC_007248.2 FR796403.1 0.6 61.4 127 - 1 - 130 2 Chr 8 NC_007249.2 FR796404.1 0.57 62.2 134 - - - 137 3 Chr 9 NC_007250.2 FR796405.1 0.57 61.1 169 3 9 - 182 1 Chr 10 NC_007251.2 FR796406.1 0.57 59.8 143 - 3 1 152 5 Chr 11 NC_007252.2 FR796407.1 0.58 59.4 132 3 7 - 148 6 Chr 12 NC_007253.2 FR796408.1 0.68 61.6 142 - - - 143 1 Chr 13 NC_007254.2 FR796409.1 0.65 60.5 170 - - - 170 - Chr 14 NC_007255.2 FR796410.1 0.62 59.9 152 - - 3 159 5 Chr 15 NC_007256.2 FR796411.1 0.63 61.7 163 1 2 43 192 3 Chr 16 NC_007257.2 FR796412.1 0.71 61.0 173 - 1 - 177 3 Chr 17 NC_007258.2 FR796413.1 0.68 60.9 157 - 3 1 162 1 Chr 18 NC_007259.2 FR796414.1 0.74 59.0 170 - - 84 219 1 Chr 19 NC_007260.2 FR796415.1 0.7 59.6 177 - - 2 179 - Chr 20 NC_007261.2 FR796416.1 0.74 59.9 176 - - 174 277 3 Chr 21 NC_007262.2 FR796417.1 0.77 60.4 225 2 4 - 233 2 Chr 22 NC_007263.2 FR796418.1 0.72 59.2 167 - - 27 183 2 Chr 23 NC_007264.2 FR796419.1 0.77 59.5 196 1 10 28 229 4 Chr 24 NC_007265.2 FR796420.1 0.84 60.4 237 - 6 2 246 1 Chr 25 NC_007266.2 FR796421.1 0.91 60.1 254 - - 123 322 2 Chr 26 NC_007267.2 FR796422.1 1.09 60.4 275 - - 218 494 2 Chr 27 NC_007268.2 FR796423.1 1.13 58.8 263 52 - 107 385 8 Chr 28 NC_007269.2 FR796424.1 1.16 59.2 316 - - - 319 3 Chr 29 NC_007270.2 FR796425.1 1.21 58.7 297 - 2 2 302 1 Chr 30 NC_007271.2 FR796426.1 1.4 58.8 395 - 1 16 408 4 Chr 31 NC_007272.2 FR796427.1 1.48 59.0 329 - 5 8 349 7 Chr 32 NC_007273.2 FR796428.1 1.6 58.8 424 - - 3 430 3 Chr 33 NC_007285.2 FR796429.1 1.58 59.1 367 - 4 80 425 5 Chr 34 NC_007286.2 FR796430.1 1.87 59.3 481 - 10 7 500 2 Chr 35 NC_007284.2 FR796431.1 2.09 58.2 535 - - 75 612 3 Chr 36 NC_007287.2 FR796432.1 2.68 58.1 731 - 13 32 781 5 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources EULEISH L.major TOP BLAST hits Leishmania Genome Network Parasite Genome Web Site Seattle Biomedical Research Institute The Sanger Institute WHO-World Health Organization