Genome

Mus musculus (house mouse) The laboratory mouse is a major model organism for basic mammalian biology, human disease, and genome evolution. Lineage: Eukaryota[15557]; Metazoa[7782]; Chordata[3579]; Craniata[3544]; Vertebrata[3544]; Euteleostomi[3500]; Mammalia[873]; Eutheria[699]; Euarchontoglires[338]; Glires[143]; Rodentia[134]; Myomorpha[82]; Muroidea[77]; Muridae[35]; Murinae[25]; Mus[6]; Mus[4]; Mus musculus[1]

The mouse is one of the major organisms for modeling human disease and comparative genome analysis. There are over 450 inbred strains of mice, providing a wealth of different genotypes and phenotypes for genetic and other studies. In addition, thousands of spontaneous, radiation- or chemically-induced, and transgenic mutants provide potential models More...for human disease. The sequence of the mouse genome will facilitate a better understanding of the human genome and provide an important tool for biomedical research. Less...

Summary Sequence data:  genome assemblies: 45; sequence reads: 372  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 2604.66  median protein count: 92499  median GC%: 41.8825 NCBI Annotation Release:  109 Publications (limited to 20 most recent records) Reference genomes for BALB/c Nude and NOD/SCID mouse models. Schmid-Siegert E, et al. G3 (Bethesda) 2023 Sep 30 PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc (Min)-Triggered Intestinal Tumor Formation. Farrall AL, et al. Cancer Res 2021 Jan 1 The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Takada T, et al. Genome Res 2013 Aug Paired-end sequencing of Fosmid libraries by Illumina. Williams LJ, et al. Genome Res 2012 Nov High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Gnerre S, et al. Proc Natl Acad Sci U S A 2011 Jan 25 Modernizing reference genome assemblies. Church DM, et al. PLoS Biol 2011 Jul Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes. Steward CA, et al. Genomics 2010 Feb Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol 2009 May 5 Revisiting the mouse mitochondrial DNA sequence. Bayona-Bafaluy MP, et al. Nucleic Acids Res 2003 Sep 15 A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science 2002 May 31 Initial sequencing and comparative analysis of the mouse genome. Mouse Genome Sequencing Consortium, et al. Nature 2002 Dec 5 More...  Representative (genome information for reference and representative genomes) Reference genome:   Mus musculus GRCm39 Submitter: Genome Reference Consortium Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_000067.7 CM000994.3 195.15 41.3 5,843 1 35 2,562 2,998 639 Chr 2 NC_000068.8 CM000995.3 181.76 42.2 7,748 - 7 3,333 3,759 663 Chr 3 NC_000069.7 CM000996.3 159.75 40.6 4,158 2 42 2,043 2,490 519 Chr 4 NC_000070.7 CM000997.3 156.86 42.5 5,889 1 8 2,444 2,916 561 Chr 5 NC_000071.7 CM000998.3 151.76 42.7 5,810 - 9 2,304 2,739 468 Chr 6 NC_000072.7 CM000999.3 149.59 41.6 4,700 2 52 2,008 2,879 609 Chr 7 NC_000073.7 CM001000.3 145 43.2 7,617 1 10 2,656 4,192 964 Chr 8 NC_000074.7 CM001001.3 130.13 42.6 4,477 48 7 2,131 2,459 421 Chr 9 NC_000075.7 CM001002.3 124.36 42.9 5,514 - 7 2,185 2,528 426 Chr 10 NC_000076.7 CM001003.3 130.53 41.6 4,357 - 11 1,927 2,303 405 Chr 11 NC_000077.7 CM001004.3 121.97 44.0 6,852 - 45 2,630 3,101 427 Chr 12 NC_000078.7 CM001005.3 120.09 42.0 3,254 2 3 1,994 2,214 554 Chr 13 NC_000079.7 CM001006.3 120.88 41.9 2,968 - 103 1,871 2,303 487 Chr 14 NC_000080.7 CM001007.3 125.14 41.4 3,615 - 13 1,795 2,329 513 Chr 15 NC_000081.7 CM001008.3 104.07 42.2 3,530 - 3 1,636 1,813 312 Chr 16 NC_000082.7 CM001009.3 98.01 41.2 2,952 1 3 1,328 1,554 288 Chr 17 NC_000083.7 CM001010.3 95.29 43.0 4,310 1 12 1,670 2,195 474 Chr 18 NC_000084.7 CM001011.3 90.72 41.7 2,301 1 - 1,149 1,351 287 Chr 19 NC_000085.7 CM001012.3 61.42 43.1 2,718 - 9 1,041 1,380 229 Chr X NC_000086.8 CM001013.3 169.48 39.6 3,479 2 21 1,086 2,515 978 Chr Y NC_000087.8 CM001014.3 91.46 39.2 313 - - 73 402 103 MT NC_005089.1 AY172335.1 0.02 36.7 13 2 22 - 37 - Un - . - 4.79 40.9 81 - - 39 104 29 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources Broad Institute CIDR Mouse Genotyping Celera Ensembl Genome Browser European Mouse Mutant Archive (EMMA) FANTOM Genoscope RH map Harwell Mouse Resource I.M.A.G.E. Consortium International Gene Trap Consortium International Mouse Strain Resource JAX Mapping Panels JAX Mice Resource MGC MGI MGI - Genealogy Chart of Inbred Strains Mutagenic Insertion and Chromosome Engineering Resource (MICER) Mutant Mouse Regional Resource Centers (MMRRC) NIA cDNA Project ORNL Mutant Mouse Database RIKEN RefSeq TIGR-BAC end sequencing The Sanger Institute Trans-NIH Mouse Initiative UCSC Genome Browser WashU-GSC