Genome

Anaplasma marginale Causative agent of bovine anaplasmosis Lineage: Bacteria[37505]; Pseudomonadota[11106]; Alphaproteobacteria[4466]; Rickettsiales[366]; Anaplasmataceae[244]; Anaplasma[8]; Anaplasma marginale[1]

Anaplasma marginale. This organism is the causative agent of bovine anaplasmosis and is an obligate intracellular pathogen. Transmission occurs via an arthropod vector (tick) and is a major problem in tropical regions where it causes severe morbidity in cattle populations. The bacterium lives intracellularly within membrane-bound vesicles More...in the host erythrocyte, a cell type which it specifically targets, resulting in severe anemia for the host organism. These bacteria express a number of major surface proteins (MSPs) which are adhesins specific for either the erythrocyte or the tick. Less...

Summary Sequence data:  genome assemblies: 23  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 1.17463  median protein count: 910  median GC%: 49.8 Publications (limited to 20 most recent records) Genetic Diversity of Tick-Borne Rickettsial Pathogens; Insights Gained from Distant Strains. Pierlé SA, et al. Pathogens 2014 Jan 14 Multistrain genome analysis identifies candidate vaccine antigens of Anaplasma marginale. Dark MJ, et al. Vaccine 2011 Jul 12 Conservation in the face of diversity: multistrain analysis of an intracellular bacterium. Dark MJ, et al. BMC Genomics 2009 Jan 11 Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Brayton KA, et al. Proc Natl Acad Sci U S A 2005 Jan 18 Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection. Stich RW, et al. Infect Immun 2004 Dec Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection. Löhr CV, et al. Infect Immun 2002 Nov Sequence and expression analysis of a surface antigen gene family of the rickettsia Anaplasma marginale. Viseshakul N, et al. Gene 2000 Jul 25 Anaplasma marginale major surface protein 3 is encoded by a polymorphic, multigene family. Alleman AR, et al. Infect Immun 1997 Jan Molecular and biological characterization of a newly isolated Anaplasma marginale strain. Eriks IS, et al. J Vet Diagn Invest 1994 Oct Putative adhesins of Anaplasma marginale: major surface polypeptides 1a and 1b. McGarey DJ, et al. Infect Immun 1994 Oct The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family. Palmer GH, et al. Infect Immun 1994 Sep Expression and immune recognition of the conserved MSP4 outer membrane protein of Anaplasma marginale. Oberle SM, et al. Infect Immun 1993 Dec The Anaplasma marginale msp5 gene encodes a 19-kilodalton protein conserved in all recognized Anaplasma species. Visser ES, et al. Infect Immun 1992 Dec More...  Representative (genome information for reference and representative genomes) Reference genome:   Anaplasma marginale str. Florida Submitter: Washington State University Morphology: Shape:Cocci Environment: OxygenReq:Aerobic, TemperatureRange:Mesophilic, Habitat:HostAssociated Phenotype: Disease:Bovine anaplasmosis Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NC_012026.1 CP001079.1 1.2 49.8 913 3 37 4 992 35 Dendrogram (based on genomic BLAST)