|
| Status |
Public on Nov 28, 2017 |
| Title |
Sex differences in peripheral not central immune responses to pain-inducing injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Women suffer chronic pain more frequently than men. It is not clear whether this is due to differences in higher level cognitive processes or basic nociceptive responses. This study used a mouse model to dissociate these factors and found no differences in peripheral afferent neurons or in the spinal cord immune response to neuropathic injury. However, it did identify potential sexual dimorphisms in peripheral adaptive immune responses.
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| |
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| Overall design |
RNA-seq of naïve FACS-purified DRG neurons and MACS-purified DRG neurons after partial sciatic nerve ligation (day 8): comparison of male versus female samples
|
| Web link |
https://0-www-nature-com.brum.beds.ac.uk/articles/s41598-017-16664-z?WT.feed_name=subjects_anatomy
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| |
|
| Contributor(s) |
Lopes D, McMahon SB, Denk F |
| Citation(s) |
29184144 |
| Submission date |
Jun 14, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Franziska Denk |
| Organization name |
King's College London
|
| Street address |
Guy's Campus
|
| City |
London |
| ZIP/Postal code |
SE1 1UL |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (28)
|
|
| Relations |
| BioProject |
PRJNA390532 |
| SRA |
SRP109190 |
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