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Series GSE100237 Query DataSets for GSE100237
Status Public on Jun 21, 2017
Title Gene expression profile of peroxisome proliferator-activated receptor delta (Ppard)-overexpressing RAW 264.7 macrophages treated vehicle, GW501516 or interleukin-4 (Il-4)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle.
Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.
Overall design 9 samples; 3 treatments in triplicate (Ppard-overexpressing RAW 264.7 cells are treated with vehicle, GW501516 or Il-4 overnight in triplicatet).
Contributor(s) Dai L, Stanya KJ, Liu S, Lee C
Citation(s) 29031719
Submission date Jun 20, 2017
Last update date Jul 25, 2021
Contact name Lingling Dai
Organization name Harvard T.H. Chan School of Public Health
Street address 665 Huntington Avenue
City Boston
State/province MA
ZIP/Postal code 02120
Country USA
Platforms (1)
GPL10192 NimbleGen Mus musculus MM9 Expression Array (12x135k)
Samples (9)
GSM2676091 Vehicle_1
GSM2676092 Vehicle_2
GSM2676093 Vehicle_3
BioProject PRJNA391143

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Supplementary file Size Download File type/resource
GSE100237_RAW.tar 36.3 Mb (http)(custom) TAR (of PAIR)
Raw data provided as supplementary file
Processed data included within Sample table

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