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| Status |
Public on Jun 19, 2018 |
| Title |
Transcriptional impact of MTHFD2 in Human Aortic Endothelial Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed transcriptome analysis of Human Aortic Endothelial Cells after siRNA mediated knockdown of MTHFD2. We identified MTHFD2 as a key driver for a gene cluster which integrates mitochondrial one-carbon metabolism, serine synthesizing enzymes as well as common amino acid and ER stress response genes.
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| |
|
| Overall design |
Human Aortic Endothelial Cells were treated with three different siRNAs against MTHFD2 or scramble for 72 h
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| |
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| Contributor(s) |
Hitzel J, Lee E, Zhu J, Brandes RP |
| Citation(s) |
29895827 |
| Submission date |
Jun 20, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Jun Zhu |
| E-mail(s) |
jun.zhu@mssm.edu
|
| Organization name |
Icahn school of medicine at mount sinai
|
| Department |
Genetics and genomic sciences
|
| Street address |
1 Gustave L. Levy Pl
|
| City |
New York |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA391168 |
| SRA |
SRP109826 |
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