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Series GSE10032 Query DataSets for GSE10032
Status Public on Jan 10, 2008
Title The acute effects of methoxyacetic acid exposure on testis gene expression
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary We evaluated the possible mechanisms by which 2-methoxyacetic acid (MAA) disrupts spermatogenesis using high density microarrays. Levels of mRNA transcripts were determined in total RNA isolated from testes of MAA-treated (650 mg/kg i.p.) or concurrent control rats sacrificed 4, 8, 12 or 24 hrs post exposure (PE).

Keywords: Toxicology, Time Course,
 
Overall design Sexually mature Sprague Dawley male rats were treated i.p. with 650 mg/kg of 2-methoxyacetic acid (CAS# 625-45-6). Treated animals were sacrificed, along with concurrent control animals 4, 8 12 or 24 hr post exposure (n=6 per treatment or control per time point, 48 total animals). Agilent 20K oligonucleotide microarrays were used to examine the levels of transcripts in whole testis total RNA. Universal rat RNA was used as reference.
 
Contributor(s) Wade MG, Yauk CL, Williams A, Kawata AK
Citation(s) 18199887
Submission date Dec 27, 2007
Last update date Dec 06, 2012
Contact name Mike G Wade
E-mail(s) Mike_Wade@hc-sc.gc.ca
Phone 613 946 5127
Fax 613 957 8800
Organization name Health Canada
Department Environmental Health Science & Research Bureau
Lab Reproductive Toxicology
Street address 50 Columbine Driveway
City Ottawa
State/province Ontario
ZIP/Postal code K1A 0K9
Country Canada
 
Platforms (1)
GPL890 Agilent-011868 Rat Oligo Microarray G4130A (Feature Number version)
Samples (47)
GSM253530 Con13
GSM253531 Con25
GSM253532 Con37
Relations
BioProject PRJNA108591

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10032_RAW.tar 30.0 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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