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Series GSE100341 Query DataSets for GSE100341
Status Public on Jun 23, 2017
Title PGC-1a Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from ParvalbuminPositive Interneurons
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PGC-1a is a master regulator for cell mitochondrial and metabolism function. In this experiment neurons were infected with a PGC-1a/GFP adenovirus to examine what genes were upregulated by over expression. Known targets related to mitochondrial health were confirmed while new neuron specific targets were discovered.
Overall design SHSY5Y cells were infected with an adenovirus containing either GFP or GFP and PGC-1a and then had their transcriptome hybridized to a microarray to observe what genes were affected.
Contributor(s) Lucas EK, Dougherty SE, McMeekin LJ, Reid CS, Dobrunz LE, West AB, Hablitz JJ, Cowell RM
Citation(s) 25339750
Submission date Jun 22, 2017
Last update date Feb 18, 2019
Contact name Rita M Cowell
Organization name Southern Research
Department Drug Discovery
Lab Neuroscience, Cowell Lab
Street address 2000 9th Ave S
City Birmingham
State/province AL
ZIP/Postal code 35205
Country USA
Platforms (1)
GPL6884 Illumina HumanWG-6 v3.0 expression beadchip
Samples (6)
GSM2678489 SHSY5Y GFP Adenovirus 1
GSM2678490 SHSY5Y GFP Adenovirus 2
GSM2678491 SHSY5Y GFP Adenovirus 3
BioProject PRJNA391482

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100341_RAW.tar 6.3 Mb (http)(custom) TAR
GSE100341_non-normalized_data.txt.gz 8.9 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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