|
| Status |
Public on Mar 05, 2018 |
| Title |
Functional TRIM24 degraders via conjugation of ineffectual bromodomain and VHL ligands [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The addressable pocket of a target protein is often not functionally relevant. This is particularly true for multidomain gene regulatory proteins, such as the bromodomain-containing transcriptional regulator TRIM24. TRIM24 has been posited as a dependency in numerous human cancers, yet potent and selective ligands for the TRIM24 bromodomain do not exert effective anti-proliferative responses. We therefore repositioned these probes as targeting features for heterobifunctional protein degraders.
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| |
|
| Overall design |
RNA-sequencing of MOLM-13 AML cells treated with DMSO, IACS-9571 or dTRIM24 for 4 or 24 hours.
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| |
|
| Contributor(s) |
Gechijian L, Gray N |
| Citation(s) |
29507391 |
| Submission date |
Jun 27, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Nathanael Gray |
| E-mail(s) |
nathanael_gray@dfci.harvard.edu
|
| Organization name |
DFCI
|
| Department |
Cancer Biology
|
| Lab |
Gray Lab
|
| Street address |
360 Longwood Ave
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE100573 |
Functional TRIM24 degraders via conjugation of ineffectual bromodomain and VHL ligands |
|
| Relations |
| BioProject |
PRJNA392162 |
| SRA |
SRP110617 |
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