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| Status |
Public on Aug 10, 2017 |
| Title |
IL-22 inhibits allergic airway inflammation in house dust mite-induced asthma models |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
While the pathogenesis of asthma is mainly orchestrated by antigen-specific Th2 cells and their cytokines, recent findings indicate the involvement of other subsets of helper T cells including Th17 cells. Previous studies have shown that IL-22, one of Th17 cell-related cytokines, plays multiple roles in regulating allergic airway inflammation; however, the mechanism underlying the Il-22-mediated regulation remains unclear. Here, we show that allergic airway inflammation upon intratracheal administration of house dust mite extract (HDM), a representative allergen, were exacerbated in IL-22-deficient mice. To address the molecular mechanisms by which IL-22 inhibits the development of HDM-induced allergic airway inflammation, we next performed an unbiased comprehensive screening of genes induced by IL-22 administration in the lung by RNA-seq analysis.
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| Overall design |
Lung total RNA profiles of wild type (WT) and IL-22 knock out mice were generated by deep sequencing, using Illumina Hiseq.
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| Contributor(s) |
Ito T, Hirose K, Nakajima H |
| Citation missing |
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| Submission date |
Jul 06, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Takashi Ito |
| E-mail(s) |
sueitoh@chiba-u.jp
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| Organization name |
Chiba university
|
| Street address |
Inohana
|
| City |
Chiba |
| State/province |
Chiba |
| ZIP/Postal code |
260-8670 |
| Country |
Japan |
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| Platforms (1) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA393301 |
| SRA |
SRP111182 |
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