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Series GSE101061 Query DataSets for GSE101061
Status Public on Sep 03, 2018
Title Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/β-catenin Signaling
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/β-catenin signaling is likely to be a major effector of its tumor-promoting role.
Overall design mRNA profiles of STRAP knock-out (KO) and control (CON) hepatocellular carcinoma cells were generated by deep sequencing, in triplicate.
Contributor(s) Wang W, van de Werken HG, Smits R
Citation(s) 30257989
Submission date Jul 10, 2017
Last update date Aug 26, 2020
Contact name Wenhui Wang
Organization name Erasmus MC
Street address Wytemaweg 80
City Rotterdam
ZIP/Postal code 3015CN
Country Netherlands
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (12)
GSM2698818 Huh6 1.4
GSM2698819 Huh6 1.33
GSM2698820 Huh6 1.36
BioProject PRJNA393645
SRA SRP111443

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Supplementary file Size Download File type/resource
GSE101061_STRAP_hcc_cpm.xlsx 5.5 Mb (ftp)(http) XLSX
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Processed data are available on Series record
Raw data are available in SRA

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