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| Status |
Public on Jul 25, 2017 |
| Title |
Expression data of lncRNA from MCF7 cells treated or not treated with TGF-β |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
TGF-β is a major inducer of epithelial-mesenchymal transition (EMT) during cancer progression, mainly by activating a set of pleiotropic transcription factors and other classes of genes
We used microarrays to detail the global programme of gene expression underlying TGF-β-induced EMT and identified distinct classes of TGF-β-regulated lncRNAs during this process.
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| Overall design |
MCF7 cells were treated with TGF-β continuously for 4 days for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain lncRNAs that are differentially regulated by TGF-β. To that end, MCF7 cells were treated with 10 ng/ml of recombinant TGF-β1 for 4 days. TGF-β1 was replenished every 2 days with a fresh medium change.
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| Contributor(s) |
Wang L, Li G |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 24, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Lei Wang |
| E-mail(s) |
rnawangl@yeah.net
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| Organization name |
Fourth Military Medical University
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| Department |
Department of Biochemistry and Molecular Biology
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| Street address |
169 Changle West Road
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| City |
Xi'an |
| ZIP/Postal code |
710032 |
| Country |
China |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (6)
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| GSM2716205 |
MCF7 cells not treated with TGF-β, biological rep1 |
| GSM2716206 |
MCF7 cells not treated with TGF-β, biological rep2 |
| GSM2716207 |
MCF7 cells not treated with TGF-β, biological rep3 |
| GSM2716208 |
MCF7 cells treated with TGF-β, biological rep1 |
| GSM2716209 |
MCF7 cells treated with TGF-β, biological rep2 |
| GSM2716210 |
MCF7 cells treated with TGF-β, biological rep3 |
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| Relations |
| BioProject |
PRJNA395566 |
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