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Series GSE10188 Query DataSets for GSE10188
Status Public on Feb 29, 2008
Title Comparative genomic analysis between adult and larval fin regeneration
Organism Danio rerio
Experiment type Expression profiling by array
Summary Zebrafish have the remarkable ability to regenerate body parts including the heart, spinal cord and fins by a process referred to as epimorphic regeneration. Recent studies have illustrated that similar to adult zebrafish, early life stage-larvae also possess the ability to regenerate the caudal fin. A comparative genomic analysis was used to determine the degree of conservation in gene expression among the regenerating adult caudal fin, adult heart and larval fin. Results indicate that these tissues respond to amputation/injury with strikingly similar genomic responses. Comparative analysis revealed raldh2, a rate-limiting enzyme for the synthesis of Retinoic acid (RA), as one of the highly induced genes across the three regeneration platforms.
Keywords: comparative genomics
Overall design The caudal fin of zebrafish larvae at 2days post fertilization were amputated. Caudal fin tissue at 2dpf and regenerating fins were isolated at 1, 2and 3 days post amputation. Three replicates were collected at each time point. 150 fins were pooled to comprise one replicate.
Contributor(s) Mathew LK, Sengupta S, Perry J, LaDu J, Andreasen EA, Tanguay RL
Citation(s) 19801676
Submission date Jan 16, 2008
Last update date Jan 25, 2018
Contact name Robert L Tanguay
Phone 541-737-6514
Organization name Oregon State University
Department EMT
Street address 1007 ALS
City Corvallis
State/province OR
ZIP/Postal code 97331
Country USA
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (24)
GSM257400 2dpf unamputated caudal fin; replicate 1
GSM257401 2dpf unamputated caudal fin; replicate 2
GSM257402 2dpf unamputated caudal fin; replicate 3
BioProject PRJNA108295

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Supplementary file Size Download File type/resource
GSE10188_RAW.tar 53.6 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Raw data provided as supplementary file

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