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| Status |
Public on Aug 06, 2008 |
| Title |
Gene Expression Analysis of laser-microdissected motorneurons in Spinal Muscular Atrophy (SMA) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype.
Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice.
Keywords: Comparative Gene Expression Analysis
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| Overall design |
The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.
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| Contributor(s) |
Corti S, Ronchi D |
| Citation(s) |
18769634 |
| Submission date |
Jan 22, 2008 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Stefania Corti |
| E-mail(s) |
stefania.corti@unimi.it
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| Phone |
+390255033817
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| Organization name |
University of Milan
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| Department |
Neurological Sciences
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| Street address |
via F. Sforza 35
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| City |
Milan |
| ZIP/Postal code |
20100 |
| Country |
Italy |
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| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA108289 |
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