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| Status |
Public on Dec 31, 2017 |
| Title |
Differentially expressed genes related to inflammatory disease on nasal cavity induced by diesel exhaust particles (DEPs) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Recently air pollution has become serious environmental issues effect. Contaminated air by pollutants, such as emission of diesel fuel, enter the human body through airway tract and can cause inflammatory diseases in respiratory system. The relation between air pollutant and development of respiratory diseases have well-studied, but the processes of disease outbreak were not fully studied yet. We investigated global gene expression induced by diesel exhaust particle (DEP), one of air pollutants in primary human nasal epithelial cell (PHNEC) with the purpose of identifying potential biomarkers. Furthermore, we analyzed signaling pathway among differentially expressed genes (DEGs) for elucidating signaling networks of process developing airway diseases. Consequentially, we suggested several key biomarkers that include not only the expression changes but also the meaning of relation between genes. This findings might be used for early diagnosis and prevention of upper respiratory disease, especially rhinitis.
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| Overall design |
Two-dose of DEP treated PHNEC. Biological replicates: 4
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|
| Contributor(s) |
Kim HJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 07, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Hyo-Jeong Kim |
| E-mail(s) |
hd414@naver.com
|
| Organization name |
Dongguk University
|
| Street address |
32, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea
|
| City |
Goyang |
| ZIP/Postal code |
10326 |
| Country |
South Korea |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (8)
|
| GSM2734289 |
DEP 50 ug/ml treated PHNEC replicate 4 |
| GSM2734290 |
DEP 200 ug/ml treated PHNEC replicate 1 |
| GSM2734291 |
DEP 200 ug/ml treated PHNEC replicate 2 |
| GSM2734292 |
DEP 200 ug/ml treated PHNEC replicate 3 |
| GSM2734293 |
DEP 200 ug/ml treated PHNEC replicate 4 |
|
| Relations |
| BioProject |
PRJNA397382 |
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