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| Status |
Public on Nov 11, 2017 |
| Title |
c-Maf-dependent transcripts in effector Tregs from Peyer's patches |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We identify c-Maf as an essential factor regulating adoption of RORgamma t+ and T follicular regulatory phenotypes in effector Tregs. Differential expression analysis demonstrates reduced signatures of both ROR gamma t+ Tregs and T follicular regulatory cells following regulatory T cell-specific c-Maf deletion.
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| Overall design |
Differential expression analysis of Peyer's patch effector Tregs (CD4+FoxP3+CD62L-) from 13-week old Maf+/+FoxP3-YFP-cre or Mafflox/floxFoxP3-YFP-cre mice, performed in duplicate.
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| |
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| Contributor(s) |
Wheaton JD, Ciofani M |
| Citation(s) |
29127150 |
| Submission date |
Aug 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Maria Ciofani |
| E-mail(s) |
maria.ciofani@duke.edu
|
| Organization name |
Duke University Medical Center
|
| Department |
Immunology
|
| Street address |
207 Research Drive, 128 Jones Building
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27710 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA397859 |
| SRA |
SRP115197 |
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